Display options
Cite
Reichhardt MP, Meri S. SALSA: A Regulator of the Early Steps of Complement Activation on Mucosal Surfaces. Front Immunol. 2016;7:85doi: 10.3389/fimmu.2016.00085.
Reichhardt, M. P., & Meri, S. (2016). SALSA: A Regulator of the Early Steps of Complement Activation on Mucosal Surfaces. Frontiers in immunology, 785. https://doi.org/10.3389/fimmu.2016.00085
Reichhardt, Martin Parnov, and Meri, Seppo. "SALSA: A Regulator of the Early Steps of Complement Activation on Mucosal Surfaces." Frontiers in immunology vol. 7 (2016): 85. doi: https://doi.org/10.3389/fimmu.2016.00085
Reichhardt MP, Meri S. SALSA: A Regulator of the Early Steps of Complement Activation on Mucosal Surfaces. Front Immunol. 2016 Mar 08;7:85. doi: 10.3389/fimmu.2016.00085. eCollection 2016. PMID: 27014265; PMCID: PMC4781872.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2016 Mar 08;7:85. doi: 10.3389/fimmu.2016.00085. eCollection 2016.

SALSA: A Regulator of the Early Steps of Complement Activation on Mucosal Surfaces.

Frontiers in immunology

Martin Parnov Reichhardt, Seppo Meri

Affiliations

  1. Immunobiology Research Program, Research Programs Unit, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki , Helsinki , Finland.

PMID: 27014265 PMCID: PMC4781872 DOI: 10.3389/fimmu.2016.00085

Abstract

Complement is present mainly in blood. However, following mechanical damage or inflammation, serous exudates enter the mucosal surfaces. Here, the complement proteins interact with other endogenous molecules to keep microbes from entering the parenteral tissues. One of the mucosal proteins known to interact with the early complement components of both the classical and the lectin pathway is the salivary scavenger and agglutinin (SALSA). SALSA is also known as deleted in malignant brain tumors 1 and gp340. It is found both attached to the epithelium and secreted into the surrounding fluids of most mucosal surfaces. SALSA has been shown to bind directly to C1q, mannose-binding lectin, and the ficolins. Through these interactions SALSA regulates activation of the complement system. In addition, SALSA interacts with surfactant proteins A and D, secretory IgA, and lactoferrin. Ulcerative colitis and Crohn's disease are examples of diseases, where complement activation in mucosal tissues may occur. This review describes the latest advances in our understanding of how the early complement components interact with the SALSA molecule. Furthermore, we discuss how these interactions may affect disease propagation on mucosal surfaces in immunological and inflammatory diseases.

Keywords: C1q; Crohn’s disease; DMBT1; IBD; MBL; ficolins; gp340; ulcerative colitis

References

  1. J Pediatr Gastroenterol Nutr. 2016 Apr;62(4):567-72 - PubMed
  2. Scand J Gastroenterol. 2011 Oct;46(10):1275-8 - PubMed
  3. Ann Intern Med. 1978 Jun;88(6):796-8 - PubMed
  4. J Crohns Colitis. 2014 Jun;8(6):521-8 - PubMed
  5. Inflamm Bowel Dis. 2010 Oct;16(10):1649-57 - PubMed
  6. J Inflamm (Lond). 2015 Sep 08;12:51 - PubMed
  7. Clin Exp Allergy. 1991 Jan;21(1):17-24 - PubMed
  8. Genes Chromosomes Cancer. 2002 Nov;35(3):242-55 - PubMed
  9. Glycobiology. 2001 Nov;11(11):969-77 - PubMed
  10. Biol Chem. 2015 Jan;396(1):35-43 - PubMed
  11. Can J Gastroenterol. 2000 Apr;14(4):337-9 - PubMed
  12. Infect Immun. 1987 Feb;55(2):288-92 - PubMed
  13. AIDS Res Hum Retroviruses. 2003 Mar;19(3):201-9 - PubMed
  14. Eur J Immunol. 2009 Mar;39(3):833-42 - PubMed
  15. Glycoconj J. 2007 Apr;24(2-3):131-42 - PubMed
  16. Biochem J. 2002 Sep 1;366(Pt 2):511-20 - PubMed
  17. Int J Mol Sci. 2010;11(12):5212-33 - PubMed
  18. Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L831-40 - PubMed
  19. Eur J Immunol. 2003 Aug;33(8):2327-36 - PubMed
  20. J Immunol. 2007 Sep 1;179(5):3126-32 - PubMed
  21. Mol Immunol. 2011 Oct;49(1-2):185-90 - PubMed
  22. J Infect Dis. 1998 Dec;178(6):1635-41 - PubMed
  23. Clin Exp Immunol. 2008 Jan;151(1):123-9 - PubMed
  24. Regul Pept. 2000 Jun 30;90(1-3):61-8 - PubMed
  25. J Dent Res. 1977 Mar;56(3):327-31 - PubMed
  26. Biochem J. 1976 Apr 1;155(1):19-23 - PubMed
  27. J Immunol. 2007 Jun 15;178(12):8203-11 - PubMed
  28. Nat Genet. 1997 Sep;17(1):32-9 - PubMed
  29. Biol Chem. 2007 Dec;388(12):1275-89 - PubMed
  30. Mol Immunol. 1993 Feb;30(3):309-19 - PubMed
  31. Antonie Van Leeuwenhoek. 2000 Jan;77(1):21-30 - PubMed
  32. PLoS One. 2013 May 15;8(5):e64441 - PubMed
  33. Crit Rev Oral Biol Med. 1991;2(3):355-67 - PubMed
  34. Cancer Res. 2000 Mar 15;60(6):1704-10 - PubMed
  35. Clin Exp Immunol. 2002 Dec;130(3):449-58 - PubMed
  36. Genes Chromosomes Cancer. 2002 Oct;35(2):164-9 - PubMed
  37. BMC Infect Dis. 2007 Jun 11;7:57 - PubMed
  38. Cancer Res. 2001 Dec 15;61(24):8880-6 - PubMed
  39. Immunol Invest. 1999 Jan;28(1):43-53 - PubMed
  40. Scand J Rheumatol. 2002;31(6):362-5 - PubMed
  41. Innate Immun. 2010 Jun;16(3):160-7 - PubMed
  42. J Thorac Cardiovasc Surg. 2009 Sep;138(3):725-32 - PubMed
  43. Biochim Biophys Acta. 2003 Nov 3;1652(1):64-74 - PubMed
  44. J Immunol. 1999 Oct 1;163(7):3957-62 - PubMed
  45. Am J Respir Cell Mol Biol. 1999 Apr;20(4):759-68 - PubMed
  46. Arch Otolaryngol Head Neck Surg. 2007 Nov;133(11):1111-4 - PubMed
  47. Front Immunol. 2012 Jul 16;3:205 - PubMed
  48. J Biol Chem. 1997 May 23;272(21):13743-9 - PubMed
  49. J Immunol. 2008 Dec 15;181(12):8433-40 - PubMed
  50. PLoS One. 2013 Nov 05;8(11):e77773 - PubMed
  51. Infect Immun. 2004 Oct;72(10):6181-4 - PubMed
  52. J Immunol. 2014 Nov 15;193(10):5240-8 - PubMed
  53. Biochem J. 2000 Oct 15;351 Pt 2:421-8 - PubMed
  54. Eur J Biochem. 1983 Jun 15;133(2):255-61 - PubMed
  55. Oncogene. 1999 Nov 4;18(46):6233-40 - PubMed
  56. Gastroenterology. 2007 Nov;133(5):1499-509 - PubMed
  57. Biochem J. 1991 Mar 1;274 ( Pt 2):481-90 - PubMed
  58. Eur J Oral Sci. 2011 Dec;119(6):435-40 - PubMed
  59. World J Gastroenterol. 2014 Mar 28;20(12 ):3223-30 - PubMed
  60. J Biol Chem. 2000 Dec 22;275(51):39860-6 - PubMed
  61. Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L606-16 - PubMed
  62. Eur J Gastroenterol Hepatol. 2003 Dec;15(12):1275-80 - PubMed
  63. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10794-9 - PubMed
  64. Infect Immun. 2005 Apr;73(4):2245-52 - PubMed
  65. Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1066-76 - PubMed
  66. J Biol Chem. 2001 May 25;276(21):18060-5 - PubMed
  67. Gastroenterology. 2008 Oct;135(4):1114-22 - PubMed
  68. Biochem J. 2004 Oct 1;383(Pt 1):159-64 - PubMed
  69. Oral Microbiol Immunol. 2008 Aug;23(4):336-43 - PubMed
  70. Infect Immun. 2006 Jul;74(7):4058-63 - PubMed
  71. FEBS Lett. 2003 Apr 10;540(1-3):21-5 - PubMed

Publication Types