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Cianciolo G, Capelli I, Cappuccilli M, et al. Calcifying circulating cells: an uncharted area in the setting of vascular calcification in CKD patients. Clin Kidney J. 2016;9(2):280-6doi: 10.1093/ckj/sfv145.
Cianciolo, G., Capelli, I., Cappuccilli, M., Schillaci, R., Cozzolino, M., & La Manna, G. (2016). Calcifying circulating cells: an uncharted area in the setting of vascular calcification in CKD patients. Clinical kidney journal, 9(2), 280-6. https://doi.org/10.1093/ckj/sfv145
Cianciolo, Giuseppe, et al. "Calcifying circulating cells: an uncharted area in the setting of vascular calcification in CKD patients." Clinical kidney journal vol. 9,2 (2016): 280-6. doi: https://doi.org/10.1093/ckj/sfv145
Cianciolo G, Capelli I, Cappuccilli M, Schillaci R, Cozzolino M, La Manna G. Calcifying circulating cells: an uncharted area in the setting of vascular calcification in CKD patients. Clin Kidney J. 2016 Apr;9(2):280-6. doi: 10.1093/ckj/sfv145. Epub 2016 Jan 18. PMID: 26985381; PMCID: PMC4792620.
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Clin Kidney J. 2016 Apr;9(2):280-6. doi: 10.1093/ckj/sfv145. Epub 2016 Jan 18.

Calcifying circulating cells: an uncharted area in the setting of vascular calcification in CKD patients.

Clinical kidney journal

Giuseppe Cianciolo, Irene Capelli, Maria Cappuccilli, Roberto Schillaci, Mario Cozzolino, Gaetano La Manna

Affiliations

  1. Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, Department of Experimental Diagnostic and Specialty Medicine (DIMES) , University of Bologna , Bologna , Italy.
  2. Nephrology and Dialysis, S. Paolo Hospital, Department of Health Sciences (DISS) , University of Milan , Milan , Italy.

PMID: 26985381 PMCID: PMC4792620 DOI: 10.1093/ckj/sfv145

Abstract

Vascular calcification, occurring during late-stage vascular and valvular disease, is highly associated with chronic kidney disease-mineral and bone disorders (CKD-MBD), representing a major risk factor for cardiovascular morbidity and mortality. The hallmark of vascular calcification, which involves both media and intima, is represented by the activation of cells committed to an osteogenic programme. Several studies have analysed the role of circulating calcifying cells (CCCs) in vascular calcification. CCCs are bone marrow (BM)-derived cells with an osteogenic phenotype, participating in intima calcification processes and defined by osteocalcin and bone alkaline phosphatase expression. The identification of CCCs in diabetes and atherosclerosis is the most recent, intriguing and yet uncharted chapter in the scenario of the bone-vascular axis. Whether osteogenic shift occurs in the BM, the bloodstream or both, is not known, and also the factors promoting CCC formation have not been identified. However, it is possible to recognize a common pathogenic commitment of inflammation in atherosclerosis and diabetes, in which metabolic control may also have a role. Currently available studies in patients without CKD did not find an association of CCCs with markers of bone metabolism. Preliminary data on CKD patients indicate an implication of mineral bone disease in vascular calcification, as a consequence of functional and anatomic integrity interruption of BM niches. Given the pivotal role that parathyroid hormone and osteoblasts play in regulating expansion, mobilization and homing of haematopoietic stem/progenitors cells, CKD-MBD could promote CCC formation.

Keywords: atherosclerosis; calcifying circulating cells; chronic kidney disease-mineral and bone disorders; mineral metabolism; vascular calcification

References

  1. Circ Res. 2012 Feb 17;110(4):624-37 - PubMed
  2. Am J Epidemiol. 2009 Jan 15;169(2):186-94 - PubMed
  3. Nephrol Dial Transplant. 2016 Mar;31(3):382-90 - PubMed
  4. Am J Pathol. 2004 Apr;164(4):1199-209 - PubMed
  5. Arch Biochem Biophys. 2008 May 15;473(2):193-200 - PubMed
  6. Am J Pathol. 2006 Oct;169(4):1440-57 - PubMed
  7. Atherosclerosis. 2012 Jul;223(1):86-94 - PubMed
  8. J Am Coll Cardiol. 2008 Oct 14;52(16):1314-25 - PubMed
  9. Stem Cells. 1997;15(5):368-77 - PubMed
  10. J Clin Endocrinol Metab. 2011 May;96(5):E830-5 - PubMed
  11. Circ Res. 2011 Sep 2;109(6):697-711 - PubMed
  12. World J Stem Cells. 2014 Nov 26;6(5):637-43 - PubMed
  13. Exp Diabetes Res. 2012;2012:921685 - PubMed
  14. Nephrol Dial Transplant. 2006 Aug;21(8):2072-4 - PubMed
  15. Exp Hematol. 2008 Jun;36(6):695-702 - PubMed
  16. J Am Soc Nephrol. 2010 Jan;21(1):103-12 - PubMed
  17. Nephrol Dial Transplant. 2014 Oct;29(10):1815-20 - PubMed
  18. Stem Cells. 2005 Aug;23(7):879-94 - PubMed
  19. Kidney Int. 2014 May;85(5):1022-3 - PubMed
  20. Circ Res. 2011 Jun 10;108(12):1494-509 - PubMed
  21. Stem Cells. 2005 Sep;23 (8):1105-12 - PubMed
  22. FASEB J. 2013 Nov;27(11):4355-65 - PubMed
  23. Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1420-5 - PubMed
  24. Nature. 2003 Oct 23;425(6960):841-6 - PubMed
  25. Stem Cells Transl Med. 2014 Aug;3(8):949-57 - PubMed
  26. Atherosclerosis. 2010 Mar;209(1):10-7 - PubMed
  27. Blood Purif. 2011;32(3):161-73 - PubMed
  28. Nature. 2014 Jan 16;505(7483):327-34 - PubMed
  29. Biochem Biophys Res Commun. 2010 Feb 26;393(1):156-61 - PubMed
  30. Nat Immunol. 2002 Jul;3(7):687-94 - PubMed
  31. Curr Pharm Des. 2010;16(35):3903-20 - PubMed
  32. Blood. 2007 Aug 1;110(3):1073 - PubMed
  33. Nature. 1997 Mar 6;386(6620):78-81 - PubMed
  34. J Pathol. 2005 Apr;205(5):641-50 - PubMed
  35. Blood Purif. 2013;35(1-3):187-95 - PubMed
  36. Bone. 2011 May 1;48(5):1127-32 - PubMed
  37. Diabetes. 2013 Sep;62(9):3207-17 - PubMed
  38. Clin J Am Soc Nephrol. 2009 Dec;4(12):1892-900 - PubMed
  39. N Engl J Med. 2004 Sep 23;351(13):1296-305 - PubMed
  40. Circulation. 2012 Jun 5;125(22):2772-81 - PubMed
  41. Lancet Diabetes Endocrinol. 2014 May;2(5):427-36 - PubMed
  42. J Hematol Oncol. 2011 May 24;4:24 - PubMed
  43. Circ Res. 2011 Apr 29;108(9):1112-21 - PubMed
  44. N Engl J Med. 2011 Dec 29;365(26):2536-8 - PubMed
  45. Blood. 2004 Dec 1;104(12):3472-82 - PubMed
  46. Eur Heart J. 2010 Dec;31(23):2909-14 - PubMed

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