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Yuki M, Komazawa Y, Kobayashi Y, et al. Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial. Curr Ther Res Clin Exp. 2015;77:58-62doi: 10.1016/j.curtheres.2015.04.002.
Yuki, M., Komazawa, Y., Kobayashi, Y., Kusunoki, M., Takahashi, Y., Nakashima, S., Uno, G., Ikuma, I., Shizuku, T., & Kinoshita, Y. (2015). Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial. Current therapeutic research, clinical and experimental, 7758-62. https://doi.org/10.1016/j.curtheres.2015.04.002
Yuki, Mika, et al. "Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial." Current therapeutic research, clinical and experimental vol. 77 (2015): 58-62. doi: https://doi.org/10.1016/j.curtheres.2015.04.002
Yuki M, Komazawa Y, Kobayashi Y, Kusunoki M, Takahashi Y, Nakashima S, Uno G, Ikuma I, Shizuku T, Kinoshita Y. Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial. Curr Ther Res Clin Exp. 2015 May 04;77:58-62. doi: 10.1016/j.curtheres.2015.04.002. eCollection 2015 Dec. PMID: 27069528; PMCID: PMC4812817.
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Curr Ther Res Clin Exp. 2015 May 04;77:58-62. doi: 10.1016/j.curtheres.2015.04.002. eCollection 2015 Dec.

Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial.

Current therapeutic research, clinical and experimental

Mika Yuki, Yoshinori Komazawa, Yoshiya Kobayashi, Maho Kusunoki, Yoshiko Takahashi, Sayaka Nakashima, Goichi Uno, Isao Ikuma, Toshihiro Shizuku, Yoshikazu Kinoshita

Affiliations

  1. Department of Internal Medicine, Izumo City General Medical Center, Izumo, Shimane, Japan.
  2. Second Department of Internal Medicine, Shimane University, School of Medicine, Izumo, Shimane, Japan.

PMID: 27069528 PMCID: PMC4812817 DOI: 10.1016/j.curtheres.2015.04.002

Abstract

BACKGROUND: Daikenchuto (DKT), a traditional Japanese herbal medicine, is widely used for treatment of gastrointestinal disorders. We evaluated the efficacy and safety of DKT for abdominal bloating in patients with chronic constipation.

OBJECTIVE: To evaluate the efficacy and safety of DKT for the treatment of abdominal bloating.

METHODS: After discontinuing as-needed use of laxatives, 10 patients received oral DKT for 14 days (15 g/d). To evaluate small intestinal bacteria overgrowth (SIBO), a glucose breath test was performed before and after treatment with DKT. Before beginning the treatment, 4 patients (40%) had a diagnosis of SIBO based on a positive glucose breath test result. In both the SIBO and non-SIBO groups, bowel movement frequency and stool form remained unchanged after DKT treatment.

RESULTS: For all patients, median total Gastrointestinal Symptoms Rating Scale score and the median Gastrointestinal Symptoms Rating Scale indigestion and constipation subscales were significantly decreased, whereas the median visual analog score for decreased abdominal bloating was significantly increased. Improvements of those symptoms were the same in both the SIBO and non-SIBO groups, indicating that DKT does not have effects on small intestine bacteria. No serious side effects were reported.

CONCLUSIONS: DKT treatment improved quality of life for patients with chronic constipation regardless of the presence of SIBO and showed no effects on small intestine bacteria. UMIN Clinical Trial Registry identifier: UMIN000008070.

Keywords: abdominal bloating; chronic constipation; daikenchuto; small intestinal bacterial overgrowth

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