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Golbin L, Dolley-Hitze T, Lorcy N, et al. Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case Rep Nephrol. 2016;2016:1971465doi: 10.1155/2016/1971465.
Golbin, L., Dolley-Hitze, T., Lorcy, N., Rioux-Leclercq, N., & Vigneau, C. (2016). Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case reports in nephrology, 20161971465. https://doi.org/10.1155/2016/1971465
Golbin, Léonard, et al. "Drug-Induced Acute Interstitial Nephritis with Nifedipine." Case reports in nephrology vol. 2016 (2016): 1971465. doi: https://doi.org/10.1155/2016/1971465
Golbin L, Dolley-Hitze T, Lorcy N, Rioux-Leclercq N, Vigneau C. Drug-Induced Acute Interstitial Nephritis with Nifedipine. Case Rep Nephrol. 2016;2016:1971465. doi: 10.1155/2016/1971465. Epub 2016 Feb 03. PMID: 26955492; PMCID: PMC4756134.
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Case Rep Nephrol. 2016;2016:1971465. doi: 10.1155/2016/1971465. Epub 2016 Feb 03.

Drug-Induced Acute Interstitial Nephritis with Nifedipine.

Case reports in nephrology

Léonard Golbin, Thibault Dolley-Hitze, Nolwenn Lorcy, Nathalie Rioux-Leclercq, Cécile Vigneau

Affiliations

  1. CHU de Rennes, Service de Néphrologie, 35033 Rennes, France.
  2. CNRS UMR 6290, Équipe Kyca, 35043 Rennes, France; CHU de Rennes, Service d'Anatomie et Cytologie Pathologiques, 35033 Rennes, France.
  3. CHU de Rennes, Service de Néphrologie, 35033 Rennes, France; CNRS UMR 6290, Équipe Kyca, 35043 Rennes, France.

PMID: 26955492 PMCID: PMC4756134 DOI: 10.1155/2016/1971465

Abstract

Background. Acute interstitial nephritis (AIN) is a frequent cause of Acute Kidney Injury (AKI). Drug hypersensitivity is the most common etiology and the list of drugs that can induce AIN is not exhaustive yet. Case Report. Here, we describe the case of a 43-year-old man who was treated with nifedipine (Adalate®) for Raynaud's syndrome. After nifedipine introduction, serum creatininemia progressively increased from 91 to 188 μmol/L in a few months and AKI was diagnosed. Laboratory work-up results indicated the presence of tubular proteinuria and nonspecific inflammatory syndrome. Histological analysis found granulomatous interstitial nephropathy without necrosis in 20% of the kidney biopsy without immunofluorescent deposit. Nifedipine was stopped and corticosteroid treatment was started with a rapid but incomplete reduction of serum creatininemia level to 106 μmol/L. Conclusion. This is the first case of AIN caused by nifedipine.

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