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Awodele O, Yemitan O, Ise PU, et al. Modulatory potentials of aqueous leaf and unripe fruit extracts of Carica papaya Linn. (Caricaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats. J Intercult Ethnopharmacol. 2016;5(1):27-35doi: 10.5455/jice.20160124113528.
Awodele, O., Yemitan, O., Ise, P. U., & Ikumawoyi, V. O. (2016). Modulatory potentials of aqueous leaf and unripe fruit extracts of Carica papaya Linn. (Caricaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats. Journal of intercultural ethnopharmacology, 5(1), 27-35. https://doi.org/10.5455/jice.20160124113528
Awodele, Olufunsho, et al. "Modulatory potentials of aqueous leaf and unripe fruit extracts of Carica papaya Linn. (Caricaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats." Journal of intercultural ethnopharmacology vol. 5,1 (2016): 27-35. doi: https://doi.org/10.5455/jice.20160124113528
Awodele O, Yemitan O, Ise PU, Ikumawoyi VO. Modulatory potentials of aqueous leaf and unripe fruit extracts of Carica papaya Linn. (Caricaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats. J Intercult Ethnopharmacol. 2016 Jan 27;5(1):27-35. doi: 10.5455/jice.20160124113528. eCollection 2016. PMID: 27069723; PMCID: PMC4805144.
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J Intercult Ethnopharmacol. 2016 Jan 27;5(1):27-35. doi: 10.5455/jice.20160124113528. eCollection 2016.

Modulatory potentials of aqueous leaf and unripe fruit extracts of Carica papaya Linn. (Caricaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats.

Journal of intercultural ethnopharmacology

Olufunsho Awodele, Omoniyi Yemitan, Peter Uduak Ise, Victor Olabowale Ikumawoyi

Affiliations

  1. Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos, Lagos, Nigeria.
  2. Department of Pharmacology, College of Medicine, Lagos State University, Lagos, Nigeria.

PMID: 27069723 PMCID: PMC4805144 DOI: 10.5455/jice.20160124113528

Abstract

INTRODUCTION: Carica papaya Linn is used in a traditional medicine for hepatobiliary disorders. This study investigated the hepatomodulatory effects of aqueous extracts of C. papaya leaf (CPL) and unripe fruit (CPF) at doses of 100 and 300 mg/kg on carbon tetrachloride (CCl4) and acetaminophen (ACM)-induced liver toxicities in rats.

MATERIALS AND METHODS: Rats were administered CCl4 (3 ml/kg in olive oil, i.p.) followed by oral administration of CPL and CPF at 2, 6 and 10 h intervals. The ACM model proceeded with the same method but inclusive of animals treated with N-acetyl cysteine (3 ml/kg i.p). At the end of the study, serum levels of liver biomarkers and antioxidant enzymes were assessed and histology of the liver tissues determined.

RESULTS: There was a significant (P < 0.05) reduction in CCl4 and ACM-induced increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and direct bilirubin at 100 and 300 mg/kg, respectively. The levels of catalase (CAT), superoxide dismutase and reduced GSH were decreased in both models with corresponding significantly (P < 0.05) elevated level of malondialdehyde. However, these antioxidant enzymes were significantly (P < 0.05) increased in CPL and CPF-treated rats. Histopathological assessment of the liver confirmed the protective effects of CPL and CPF on CCl4 and ACM-induced hepatic damage evidenced by the normal presentation of liver tissue architecture.

CONCLUSION: These results indicate that aqueous extracts of C. papaya may be useful in preventing CCl4 and ACM-induced liver toxicities.

Keywords: Acetaminophen; Carica papaya; antioxidant; carbon tetrachloride; hepatotoxicity; histopathological assessment

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