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Foeken K, van de Wetering BJ. Manic episode, thyroid gland function and lithium. Acta Neuropsychiatr. 1992;4(3):52-6doi: 10.1017/S0924270800034797.
Foeken, K., & van de Wetering, B. J. (1992). Manic episode, thyroid gland function and lithium. Acta neuropsychiatrica, 4(3), 52-6. https://doi.org/10.1017/S0924270800034797
Foeken, K, and van de Wetering, B J. "Manic episode, thyroid gland function and lithium." Acta neuropsychiatrica vol. 4,3 (1992): 52-6. doi: https://doi.org/10.1017/S0924270800034797
Foeken K, van de Wetering BJ. Manic episode, thyroid gland function and lithium. Acta Neuropsychiatr. 1992 Sep;4(3):52-6. doi: 10.1017/S0924270800034797. PMID: 26956631.
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Acta Neuropsychiatr. 1992 Sep;4(3):52-6. doi: 10.1017/S0924270800034797.

Manic episode, thyroid gland function and lithium.

Acta neuropsychiatrica

K Foeken, B J van de Wetering

Affiliations

  1. destijds verbonden aan de afdeling Psychiatrie van het Academisch Ziekenhuis Rotterdam-Dijkzigt (hoofd: Prof. dr. W.J. Schudel) thans Sophia Kinderziekenhuis.
  2. verbonden aan de afdeling Psychiatrie van het AZR-Dijkzigt.

PMID: 26956631 DOI: 10.1017/S0924270800034797

Abstract

This paper addresses the issue of (recurrent) mania in relation to an increased T4-value, whether or not influenced by lithium. Lithium has an anti-TSH-effect on the thyroid gland by inhibiting the intracellular enzyme adenylate cyclase. This might cause hypothyroidism. Moreover, lithium is also known to have a direct stabilizing effect on (behavioral manifestations) of dopamine receptor supersensitivity. The hypothesis regarding the relation between thyroid function and affective disturbances is that the altered thyroid function may cause a change in the availability of the central dopamine receptors. Dopamine is known to be able to cause a manic state. TSH and TRH are also involved in this mechanism. It is, therefore, very likely that an increased thyroid function, whether or not caused by discontinuation of lithium-therapy, could induce a (recurrent) mania.

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