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Zhu XY, Xia B, Liu HC, et al. Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models. Assay Drug Dev Technol. 2016;14(5):282-290doi: 10.1089/adt.2015.679.
Zhu, X. Y., Xia, B., Liu, H. C., Xu, Y. Q., Huang, C. J., Gao, J. M., Dong, Q. X., & Li, C. Q. (2016). Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models. Assay and drug development technologies, 14(5), 282-290. https://doi.org/10.1089/adt.2015.679
Zhu, Xiao-Yu, et al. "Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models." Assay and drug development technologies vol. 14,5 (2016): 282-290. doi: https://doi.org/10.1089/adt.2015.679
Zhu XY, Xia B, Liu HC, Xu YQ, Huang CJ, Gao JM, Dong QX, Li CQ. Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models. Assay Drug Dev Technol. 2016 Jul;14(5):282-290. doi: 10.1089/adt.2015.679. Epub 2016 Apr 05. PMID: 27045536.
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Assay Drug Dev Technol. 2016 Jul;14(5):282-290. doi: 10.1089/adt.2015.679. Epub 2016 Apr 05.

Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models.

Assay and drug development technologies

Xiao-Yu Zhu, Bo Xia, Hong-Cui Liu, Yi-Qiao Xu, Chang-Jiang Huang, Ji-Min Gao, Qiao-Xiang Dong, Chun-Qi Li

Affiliations

  1. 1 Zhejiang Provincial Key Lab for Technology and Application of Model Organisms, Wenzhou Medical University , Wenzhou, P.R. China .
  2. 2 Hunter Biotechnology, Inc., Hangzhou, P.R. China .
  3. 3 Institute of Watershed Science and Environmental Ecology, Wenzhou Medical University , Wenzhou, P.R. China .

PMID: 27045536 DOI: 10.1089/adt.2015.679

Abstract

Angiogenesis has emerged as an important therapeutic target in several major diseases, including cancer and age-related macular degeneration. The zebrafish offer the potential for high-throughput drug discovery in a whole vertebrate system. In this study, we have taken advantage of the transgenic Tg (fli1a:EGFP) zebrafish line to screen the U.S. Drug Collection Library and identified 11 old drugs with antiangiogenic activity, including Closantel, an FDA-approved broad-spectrum salicylanilide antiparasitic drug for a variety of types of animals. Closantel was confirmed to have antiangiogenic activity in zebrafish with a half-inhibitory concentration (IC

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