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Tsunenari T, Aosasa S, Ogata S, et al. Synchronous neuroendocrine tumors in both the pancreas and ileum: A case report. Int J Surg Case Rep. 2016;22:47-50doi: 10.1016/j.ijscr.2016.03.028.
Tsunenari, T., Aosasa, S., Ogata, S., Hoshikawa, M., Nishikawa, M., Noro, T., Shinto, E., Tsujimoto, H., Ueno, H., Hamabe, F., Shinmoto, H., Hase, K., & Yamamoto, J. (2016). Synchronous neuroendocrine tumors in both the pancreas and ileum: A case report. International journal of surgery case reports, 2247-50. https://doi.org/10.1016/j.ijscr.2016.03.028
Tsunenari, Takazumi, et al. "Synchronous neuroendocrine tumors in both the pancreas and ileum: A case report." International journal of surgery case reports vol. 22 (2016): 47-50. doi: https://doi.org/10.1016/j.ijscr.2016.03.028
Tsunenari T, Aosasa S, Ogata S, Hoshikawa M, Nishikawa M, Noro T, Shinto E, Tsujimoto H, Ueno H, Hamabe F, Shinmoto H, Hase K, Yamamoto J. Synchronous neuroendocrine tumors in both the pancreas and ileum: A case report. Int J Surg Case Rep. 2016;22:47-50. doi: 10.1016/j.ijscr.2016.03.028. Epub 2016 Mar 24. PMID: 27046104; PMCID: PMC4823476.
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Int J Surg Case Rep. 2016;22:47-50. doi: 10.1016/j.ijscr.2016.03.028. Epub 2016 Mar 24.

Synchronous neuroendocrine tumors in both the pancreas and ileum: A case report.

International journal of surgery case reports

Takazumi Tsunenari, Suefumi Aosasa, Sho Ogata, Mayumi Hoshikawa, Makoto Nishikawa, Takuji Noro, Eiji Shinto, Hironori Tsujimoto, Hideki Ueno, Fumiko Hamabe, Hiroshi Shinmoto, Kazuo Hase, Junji Yamamoto

Affiliations

  1. Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
  2. Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. Electronic address: [email protected].
  3. Department of Laboratory Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
  4. Department of Radiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

PMID: 27046104 PMCID: PMC4823476 DOI: 10.1016/j.ijscr.2016.03.028

Abstract

INTRODUCTION: Although it is well-known that in multiple endocrine neoplasia type 1 (MEN 1) disease, multiple endocrine lesions frequently occur, synchronous or metachronous neuroendocrine tumors (NETs) in non-MEN 1 patients are extremely rare.

PRESENTATION OF CASE: An asymptomatic 72-year-old woman with an ileal NET was referred to our hospital. Abdominal computed tomography revealed another circular tumor within the pancreatic head. She was classified as a non-MEN 1 patient. An operative procedure was performed with a preoperative diagnosis of synchronous NET, which was confirmed by pathological examination.

DISCUSSION: Both morphologic and immunophenotypic findings were different between in the ileum and pancreas. Therefore, it was reasonable to consider that both tumors were primary tumors. The synchronous occurrence of these tumors is unusual, and it may be considered as a chance occurrence.

CONCLUSION: We here report the first case of synchronous pancreatic NET and ileal NET in a non-MEN 1 patient.

Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords: Case report; Ileum; Neuroendocrine tumor; Pancreas

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