Display options
Cite
Shen J, LaChaud G, Shrestha S, et al. NELL-1 expression in tumors of cartilage. J Orthop. 2015;12:S223-9doi: 10.1016/j.jor.2015.10.001.
Shen, J., LaChaud, G., Shrestha, S., Asatrian, G., Zhang, X., Dry, S. M., Soo, C., Ting, K., & James, A. W. (2015). NELL-1 expression in tumors of cartilage. Journal of orthopaedics, 12S223-9. https://doi.org/10.1016/j.jor.2015.10.001
Shen, Jia, et al. "NELL-1 expression in tumors of cartilage." Journal of orthopaedics vol. 12 (2015): S223-9. doi: https://doi.org/10.1016/j.jor.2015.10.001
Shen J, LaChaud G, Shrestha S, Asatrian G, Zhang X, Dry SM, Soo C, Ting K, James AW. NELL-1 expression in tumors of cartilage. J Orthop. 2015 Oct 27;12:S223-9. doi: 10.1016/j.jor.2015.10.001. eCollection 2015 Dec. PMID: 27047227; PMCID: PMC4796526.
Copy Download .nbib Format: NLM
Share it on

J Orthop. 2015 Oct 27;12:S223-9. doi: 10.1016/j.jor.2015.10.001. eCollection 2015 Dec.

NELL-1 expression in tumors of cartilage.

Journal of orthopaedics

Jia Shen, Gregory LaChaud, Swati Shrestha, Greg Asatrian, Xinli Zhang, Sarah M Dry, Chia Soo, Kang Ting, Aaron W James

Affiliations

  1. Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States.
  2. Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States; Vanderbilt University School of Medicine, Nashville, TN 37212, United States.
  3. Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States.
  4. Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States.
  5. Division of Plastic and Reconstructive Surgery, Department of Surgery, UCLA, Los Angeles, CA 90095, United States; UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States.
  6. Division of Growth and Development and Section of Orthodontics, School of Dentistry UCLA, Los Angeles, CA 90095, United States; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, United States; UCLA and Orthopaedic Hospital, Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States.

PMID: 27047227 PMCID: PMC4796526 DOI: 10.1016/j.jor.2015.10.001

Abstract

BACKGROUND/AIMS: NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors.

METHODS: Immunohistochemical expression was examined in human pathologic specimens.

RESULTS: Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade.

CONCLUSION: In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.

Keywords: Chondroblastic osteosarcoma; Chondrosarcoma; Enchondroma; Nell-1; Osteosarcoma

References

  1. J Bone Miner Res. 1999 Jan;14(1):80-9 - PubMed
  2. Cancer. 1988 Feb 1;61(3):569-73 - PubMed
  3. Toxicol Pathol. 2002 May-Jun;30(3):312-21 - PubMed
  4. Gastroenterology. 2006 Sep;131(3):797-808 - PubMed
  5. Endocrinol Metab Clin North Am. 2012 Sep;41(3):643-54 - PubMed
  6. Int Orthop. 2014 Nov;38(11):2313-22 - PubMed
  7. Int Orthop. 2012 Oct;36(10 ):2181-7 - PubMed
  8. Nat Commun. 2015 Jun 17;6:7362 - PubMed
  9. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S151-8 - PubMed
  10. J Orthop Sci. 2013 Jul;18(4):646-57 - PubMed
  11. Tissue Eng Part A. 2011 Dec;17 (23-24):2911-8 - PubMed
  12. Tissue Eng Part A. 2010 Sep;16(9):2861-70 - PubMed
  13. J Clin Endocrinol Metab. 2002 Oct;87(10):4528-35 - PubMed
  14. Exp Cell Res. 2006 Nov 15;312(19):3927-38 - PubMed
  15. J Dent Res. 2010 Sep;89(9):865-78 - PubMed
  16. Oncogene. 2007 Sep 20;26(43):6332-40 - PubMed
  17. Int J Oncol. 2002 Jan;20(1):143-7 - PubMed
  18. Am J Pathol. 2006 Sep;169(3):903-15 - PubMed
  19. Cancer. 1985 Oct 1;56(7):1682-7 - PubMed
  20. Tissue Eng Part A. 2011 Apr;17 (7-8):1123-35 - PubMed
  21. Bone. 2007 Jun;40(6):1434-46 - PubMed
  22. Cancer. 1994 Aug 1;74(3):842-7 - PubMed
  23. N Engl J Med. 2001 May 10;344(19):1434-41 - PubMed
  24. Tissue Eng Part A. 2010 May;16(5):1791-800 - PubMed
  25. Plast Reconstr Surg. 2011 Feb;127(2):580-7 - PubMed
  26. J Cell Biochem. 2012 Dec;113(12):3620-8 - PubMed
  27. Biochem Biophys Res Commun. 2015 May 1;460(2):368-74 - PubMed
  28. Cancer Sci. 2015 May;106(5):656-64 - PubMed

Publication Types

Grant support