Display options
Cite
Kyaw Tun T, McGowan A, Phelan N, et al. Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome. Int J Endocrinol. 2016;2016:9545239doi: 10.1155/2016/9545239.
Kyaw Tun, T., McGowan, A., Phelan, N., Correia, N., Boran, G., O'Connor, A. L., Roche, H. M., & Gibney, J. (2016). Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome. International journal of endocrinology, 20169545239. https://doi.org/10.1155/2016/9545239
Kyaw Tun, Tommy, et al. "Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome." International journal of endocrinology vol. 2016 (2016): 9545239. doi: https://doi.org/10.1155/2016/9545239
Kyaw Tun T, McGowan A, Phelan N, Correia N, Boran G, O'Connor AL, Roche HM, Gibney J. Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome. Int J Endocrinol. 2016;2016:9545239. doi: 10.1155/2016/9545239. Epub 2016 Feb 18. PMID: 26989412; PMCID: PMC4775795.
Copy Download .nbib Format: NLM
Share it on

Int J Endocrinol. 2016;2016:9545239. doi: 10.1155/2016/9545239. Epub 2016 Feb 18.

Obesity and Insulin Resistance Are the Main Determinants of Postprandial Lipoprotein Dysmetabolism in Polycystic Ovary Syndrome.

International journal of endocrinology

Tommy Kyaw Tun, Anne McGowan, Niamh Phelan, Neuman Correia, Gerard Boran, Anna-Louise O'Connor, Helen M Roche, James Gibney

Affiliations

  1. Department of Endocrinology and Diabetes, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
  2. Department of Chemical Pathology, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
  3. Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, Ireland.

PMID: 26989412 PMCID: PMC4775795 DOI: 10.1155/2016/9545239

Abstract

Postprandial dyslipidaemia may be a plausible mechanism by which polycystic ovary syndrome (PCOS) increases cardiovascular risk. We sought to investigate whether the postprandial glucose and insulin and lipid and lipoprotein responses, including that of apolipoprotein B-48 (apoB-48) containing chylomicrons, to a mixed meal are different in obese PCOS women when compared to obese control subjects and whether differences, if any, are related to obesity, insulin resistance (IR), hyperandrogenaemia, or PCOS status. 26 women with PCOS (age 30.4 ± 1.2 years (mean ± SEM), body mass index (BMI) 36.8 ± 1.5 kg/m(2)) and 26 non-PCOS subjects (age 34.1 ± 0.9 years, BMI 31.5 ± 1.0 kg/m(2)) were studied before and up to 8 hours following a standard mixed meal. AUC-triglyceride (AUC-TG) was higher and AUC-high-density lipoprotein (AUC-HDL) lower in PCOS women. These differences were not apparent when BMI was accounted for. Insulin sensitivity (S I), AUC-apoB-48, and AUC-apolipoprotein B (AUC-apoB) were found to be independent predictors of AUC-TG, accounting for 55% of the variance. Only AUC-insulin remained significantly elevated following adjustment for BMI. Obesity related IR explains postprandial hypertriglyceridaemia and hyperinsulinaemic responses. Management of obesity in premenopausal women with PCOS is likely to reduce their cardiovascular risk burden.

References

  1. Am J Clin Nutr. 2002 Aug;76(2):311-8 - PubMed
  2. Diabetes Care. 2001 Apr;24(4):683-9 - PubMed
  3. Fertil Steril. 2000 Dec;74(6):1159-63 - PubMed
  4. J Cardiovasc Risk. 1996 Apr;3(2):213-9 - PubMed
  5. J Lipid Res. 1999 Jan;40(1):1-16 - PubMed
  6. Arch Intern Med. 2003 May 12;163(9):1077-83 - PubMed
  7. Endocr Rev. 1997 Dec;18(6):774-800 - PubMed
  8. Fertil Steril. 2004 Sep;82(3):661-5 - PubMed
  9. J Clin Endocrinol Metab. 2006 Feb;91(2):492-7 - PubMed
  10. Am J Cardiol. 1999 May 13;83(9B):13F-16F - PubMed
  11. Clin Chem. 2000 Oct;46(10):1638-42 - PubMed
  12. Diabetologia. 1989 May;32(5):300-4 - PubMed
  13. Circulation. 1979 Sep;60(3):473-85 - PubMed
  14. Fertil Steril. 2007 Jun;87(6):1363-8 - PubMed
  15. Arterioscler Thromb. 1991 May-Jun;11(3):653-62 - PubMed
  16. Hum Reprod. 2000 Jun;15(6):1266-74 - PubMed
  17. J Lipid Res. 2003 Jun;44(6):1256-62 - PubMed
  18. Atherosclerosis. 2004 Apr;173(2):309-14 - PubMed
  19. Diabetes. 2001 Feb;50(2):462-9 - PubMed
  20. Arterioscler Thromb Vasc Biol. 1995 Mar;15(3):320-4 - PubMed
  21. J Clin Endocrinol Metab. 2005 Apr;90(4):1929-35 - PubMed
  22. Diabetes. 1989 Sep;38(9):1165-74 - PubMed
  23. Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2448-55 - PubMed
  24. Circulation. 1993 Dec;88(6):2762-70 - PubMed
  25. Am J Med. 2001 Dec 1;111(8):607-13 - PubMed

Publication Types