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Graudal NA, Hubeck-Graudal T, Jürgens G. Reduced Dietary Sodium Intake Increases Heart Rate. A Meta-Analysis of 63 Randomized Controlled Trials Including 72 Study Populations. Front Physiol. 2016;7:111doi: 10.3389/fphys.2016.00111.
Graudal, N. A., Hubeck-Graudal, T., & Jürgens, G. (2016). Reduced Dietary Sodium Intake Increases Heart Rate. A Meta-Analysis of 63 Randomized Controlled Trials Including 72 Study Populations. Frontiers in physiology, 7111. https://doi.org/10.3389/fphys.2016.00111
Graudal, Niels A, et al. "Reduced Dietary Sodium Intake Increases Heart Rate. A Meta-Analysis of 63 Randomized Controlled Trials Including 72 Study Populations." Frontiers in physiology vol. 7 (2016): 111. doi: https://doi.org/10.3389/fphys.2016.00111
Graudal NA, Hubeck-Graudal T, Jürgens G. Reduced Dietary Sodium Intake Increases Heart Rate. A Meta-Analysis of 63 Randomized Controlled Trials Including 72 Study Populations. Front Physiol. 2016 Mar 24;7:111. doi: 10.3389/fphys.2016.00111. eCollection 2016. PMID: 27047393; PMCID: PMC4805644.
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Front Physiol. 2016 Mar 24;7:111. doi: 10.3389/fphys.2016.00111. eCollection 2016.

Reduced Dietary Sodium Intake Increases Heart Rate. A Meta-Analysis of 63 Randomized Controlled Trials Including 72 Study Populations.

Frontiers in physiology

Niels A Graudal, Thorbjørn Hubeck-Graudal, Gesche Jürgens

Affiliations

  1. Department VRR4242, Rigshospitalet, Copenhagen University Hospital Copenhagen, Denmark.
  2. Department of Nuclear Medicine, Herning Hospital Herning, Denmark.
  3. Clinical Pharmacological Unit, Zealand University Hospital Roskilde, Denmark.

PMID: 27047393 PMCID: PMC4805644 DOI: 10.3389/fphys.2016.00111

Abstract

Reduced dietary sodium intake (sodium reduction) increases heart rate in some studies of animals and humans. As heart rate is independently associated with the development of heart failure and increased risk of premature death a potential increase in heart rate could be a harmful side-effect of sodium reduction. The purpose of the present meta-analysis was to investigate the effect of sodium reduction on heart rate. Relevant studies were retrieved from an updated pool of 176 randomized controlled trials (RCTs) published in the period 1973-2014. Sixty-three of the RCTs including 72 study populations reported data on heart rate. In a meta-analysis of these data sodium reduction increased heart rate with 1.65 beats per minute [95% CI: 1.19, 2.11], p < 0.00001, corresponding to 2.4% of the baseline heart rate. This effect was independent of baseline blood pressure. In conclusion sodium reduction increases heart rate by as much (2.4%) as it decreases blood pressure (2.5%). This side-effect, which may cause harmful health effects, contributes to the need for a revision of the present dietary guidelines.

Keywords: blood pressure; dietary sodium; heart rate; meta-analysis; side-effect

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