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Markham KB, Scrape SR, Prasad M, et al. Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use. AJP Rep. 2016;6(1):e129-32doi: 10.1055/s-0036-1579646.
Markham, K. B., Scrape, S. R., Prasad, M., Rossi, K. Q., & O'Shaughnessy, R. W. (2016). Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use. AJP reports, 6(1), e129-32. https://doi.org/10.1055/s-0036-1579646
Markham, Kara B, et al. "Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use." AJP reports vol. 6,1 (2016): e129-32. doi: https://doi.org/10.1055/s-0036-1579646
Markham KB, Scrape SR, Prasad M, Rossi KQ, O'Shaughnessy RW. Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use. AJP Rep. 2016 Mar;6(1):e129-32. doi: 10.1055/s-0036-1579646. PMID: 26989567; PMCID: PMC4794441.
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AJP Rep. 2016 Mar;6(1):e129-32. doi: 10.1055/s-0036-1579646.

Hemolytic Disease of the Fetus and Newborn due to Intravenous Drug Use.

AJP reports

Kara B Markham, Scott R Scrape, Mona Prasad, Karen Q Rossi, Richard W O'Shaughnessy

Affiliations

  1. Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
  2. Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
  3. Department of Obstetrics and Gynecology, Mount Carmel Health System, Columbus, Ohio.

PMID: 26989567 PMCID: PMC4794441 DOI: 10.1055/s-0036-1579646

Abstract

Objectives The objective is to present a pregnancy complication associated with intravenous drug use, namely, that of red blood cell alloimmunization and hemolytic disease of the fetus and newborn. Methods An observational case series is presented including women with red blood cell alloimmunization most likely secondary to intravenous drug abuse Results Five pregnancies were identified that were complicated by red blood cell alloimmunization and significant hemolytic disease of the fetus and newborn, necessitating intrauterine transfusion, an indicated preterm birth, or neonatal therapy. Conclusions As opioid abuse continues to increase in the United States, clinicians should be aware of the potential for alloimmunization to red blood cell antibodies as yet another negative outcome from intravenous drug abuse.

Keywords: alloimmunization; fetus; hemolytic disease; intravenous drug use; newborn; opiate abuse; red blood cell

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