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Khammissa RA, Fourie J, Chandran R, et al. Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review. Int J Dent. 2016;2016:4941783doi: 10.1155/2016/4941783.
Khammissa, R. A., Fourie, J., Chandran, R., Lemmer, J., & Feller, L. (2016). Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review. International journal of dentistry, 20164941783. https://doi.org/10.1155/2016/4941783
Khammissa, Razia Abdool Gafaar, et al. "Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review." International journal of dentistry vol. 2016 (2016): 4941783. doi: https://doi.org/10.1155/2016/4941783
Khammissa RA, Fourie J, Chandran R, Lemmer J, Feller L. Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review. Int J Dent. 2016;2016:4941783. doi: 10.1155/2016/4941783. Epub 2016 Mar 07. PMID: 27047546; PMCID: PMC4800082.
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Int J Dent. 2016;2016:4941783. doi: 10.1155/2016/4941783. Epub 2016 Mar 07.

Epstein-Barr Virus and Its Association with Oral Hairy Leukoplakia: A Short Review.

International journal of dentistry

Razia Abdool Gafaar Khammissa, Jeanine Fourie, Rakesh Chandran, Johan Lemmer, Liviu Feller

Affiliations

  1. Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Ga-Rankuwa 0208, South Africa.

PMID: 27047546 PMCID: PMC4800082 DOI: 10.1155/2016/4941783

Abstract

In immunocompromised subjects, Epstein-Barr virus (EBV) infection of terminally differentiated oral keratinocytes may result in subclinical productive infection of the virus in the stratum spinosum and in the stratum granulosum with shedding of infectious virions into the oral fluid in the desquamating cells. In a minority of cases this productive infection with dysregulation of the cell cycle of terminally differentiated epithelial cells may manifest as oral hairy leukoplakia. This is a white, hyperkeratotic, benign lesion of low morbidity, affecting primarily the lateral border of the tongue. Factors that determine whether productive EBV replication within the oral epithelium will cause oral hairy leukoplakia include the fitness of local immune responses, the profile of EBV gene expression, and local environmental factors.

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