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Cheung A, Levitt A, Cheng M, et al. A Pilot Study of Citalopram Treatment in Preventing Relapse of Depressive Episode after Acute Treatment. J Can Acad Child Adolesc Psychiatry. 2016;25(1):11-6
Cheung, A., Levitt, A., Cheng, M., Santor, D., Kutcher, S., Dubo, E., Jane Garland, E., Weiss, M., & Kiss, A. (2016). A Pilot Study of Citalopram Treatment in Preventing Relapse of Depressive Episode after Acute Treatment. Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent, 25(1), 11-6.
Cheung, Amy, et al. "A Pilot Study of Citalopram Treatment in Preventing Relapse of Depressive Episode after Acute Treatment." Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent vol. 25,1 (2016): 11-6.
Cheung A, Levitt A, Cheng M, Santor D, Kutcher S, Dubo E, Jane Garland E, Weiss M, Kiss A. A Pilot Study of Citalopram Treatment in Preventing Relapse of Depressive Episode after Acute Treatment. J Can Acad Child Adolesc Psychiatry. 2016;25(1):11-6. Epub 2016 Feb 01. PMID: 27047552; PMCID: PMC4791101.
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J Can Acad Child Adolesc Psychiatry. 2016;25(1):11-6. Epub 2016 Feb 01.

A Pilot Study of Citalopram Treatment in Preventing Relapse of Depressive Episode after Acute Treatment.

Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

Amy Cheung, Anthony Levitt, Michael Cheng, Darcy Santor, Stan Kutcher, Elyse Dubo, E Jane Garland, Margaret Weiss, Alex Kiss

Affiliations

  1. University of Toronto, Toronto, Ontario; Sunnybrook Health Sciences Centre, Toronto, Ontario.
  2. University of Ottawa, Ottawa, Ontario; Children's Hospital of Eastern Ontario, Ottawa, Ontario.
  3. University of Ottawa, Ottawa, Ontario.
  4. Dalhousie University, Halifax, Nova Scotia.
  5. University of British Columbia, Vancouver, British Columbia.

PMID: 27047552 PMCID: PMC4791101

Abstract

PURPOSE: To examine the benefit of continuation treatment with citalopram in adolescents 13 to 18 years of age with major depression using a multi-site randomized placebo controlled discontinuation design.

METHODS: Subjects with depression who responded to open label treatment with citalopram in 12-week acute phase were randomized to continued treatment with citalopram or placebo for 24 weeks.

RESULTS: Twenty five subjects were randomized to either continued treatment with citalopram (n = 12) versus placebo (n = 13). Seventy-five percent of subjects on citalopram (75%) remained well as compared to placebo (62%). Time to relapse was compared between groups using the log rank test and was not found to be significantly different (χ(2)(1) = 0.35, P = 0.55). A Cox proportional hazards model including drug assignment (hazard ratio (HR = 0.51, 95% CI 0.11 to 2.36, P = 0.39), gender (HR = 0.58, 95% CI 0.14 to 2.37, P = 0.44), or HAM-score at entry to continuation phase (HR = 1.33, 95% CI 0.90 to 1.95, P = 0.95) was not significant.

CONCLUSION: Although we did not find statistically significant differences between citalopram and placebo, the findings suggest a possible benefit of continued treatment with citalopram over placebo. A larger clinical trial with adequate power is required to confirm or disconfirm these findings.

Keywords: adolescents; antidepressants; citalopram; depression

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