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Koskinen JP, Kiviranta H, Vartiainen E, et al. Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia. Clin Transl Allergy. 2016;6:14doi: 10.1186/s13601-016-0103-1.
Koskinen, J. P., Kiviranta, H., Vartiainen, E., Jousilahti, P., Vlasoff, T., von Hertzen, L., Mäkelä, M., Laatikainen, T., & Haahtela, T. (2016). Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia. Clinical and translational allergy, 614. https://doi.org/10.1186/s13601-016-0103-1
Koskinen, Jyri-Pekka, et al. "Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia." Clinical and translational allergy vol. 6 (2016): 14. doi: https://doi.org/10.1186/s13601-016-0103-1
Koskinen JP, Kiviranta H, Vartiainen E, Jousilahti P, Vlasoff T, von Hertzen L, Mäkelä M, Laatikainen T, Haahtela T. Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia. Clin Transl Allergy. 2016 Apr 04;6:14. doi: 10.1186/s13601-016-0103-1. eCollection 2016. PMID: 27047657; PMCID: PMC4819273.
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Clin Transl Allergy. 2016 Apr 04;6:14. doi: 10.1186/s13601-016-0103-1. eCollection 2016.

Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia.

Clinical and translational allergy

Jyri-Pekka Koskinen, Hannu Kiviranta, Erkki Vartiainen, Pekka Jousilahti, Tiina Vlasoff, Leena von Hertzen, Mika Mäkelä, Tiina Laatikainen, Tari Haahtela

Affiliations

  1. Department of Allergy, Skin and Allergy Hospital, Helsinki University Hospital, Jatasalmentie 14a, 00830 Helsinki, Finland.
  2. Department of Health Protection, National Institute for Health and Welfare, Kuopio, Finland.
  3. Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
  4. North Karelia Center for Public Health, Joensuu, Finland.
  5. Department of Health, National Institute for Health and Welfare, Helsinki, Finland ; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland ; Hospital District of North Karelia, Joensuu, Finland.

PMID: 27047657 PMCID: PMC4819273 DOI: 10.1186/s13601-016-0103-1

Abstract

BACKGROUND: Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic school-aged children and their mothers, were studied. Atopy was defined as having at least one positive skin prick test response to 14 common inhalant and food allergens tested. Concentrations of 11 common environmental pollutants were measured in blood samples.

RESULTS: Overall, the chemical levels were much higher in Russia than in Finland, except for 2,2',4,4'-tetra-bromodiphenyl ether (BDE47). In Finland but not in Russia, the atopic children had higher concentrations of polychlorinated biphenyls and 1,1-Dichloro-2,2-bis-(p-chlorophenyl)-ethylene (DDE) than the non-atopic children. In Russia but not in Finland, the atopic mothers had higher DDE concentrations than the non-atopic mothers.

CONCLUSIONS: Higher concentrations of common environmental chemicals were measured in Russian compared with Finnish Karelian children and mothers. The chemicals did not explain the higher prevalence of atopy on the Finnish side.

Keywords: Allergy; Atopy; Environmental chemicals; Finnish Karelia; Russian Karelia

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