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Wang HX, Hemler ME. Novel impact of EWI-2, CD9, and CD81 on TGF-β signaling in melanoma. Mol Cell Oncol. 2015;2(1)doi: 10.1080/23723556.2015.1030536.
Wang, H. X., & Hemler, M. E. (2015). Novel impact of EWI-2, CD9, and CD81 on TGF-β signaling in melanoma. Molecular & cellular oncology, 2(1), . https://doi.org/10.1080/23723556.2015.1030536
Wang, Hong-Xing, and Hemler, Martin E. "Novel impact of EWI-2, CD9, and CD81 on TGF-β signaling in melanoma." Molecular & cellular oncology vol. 2,1 (2015). doi: https://doi.org/10.1080/23723556.2015.1030536
Wang HX, Hemler ME. Novel impact of EWI-2, CD9, and CD81 on TGF-β signaling in melanoma. Mol Cell Oncol. 2015 Oct 02;2(1). doi: 10.1080/23723556.2015.1030536. Epub 2015 Apr 15. PMID: 26989766; PMCID: PMC4792032.
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Mol Cell Oncol. 2015 Oct 02;2(1). doi: 10.1080/23723556.2015.1030536. Epub 2015 Apr 15.

Novel impact of EWI-2, CD9, and CD81 on TGF-β signaling in melanoma.

Molecular & cellular oncology

Hong-Xing Wang, Martin E Hemler

Affiliations

  1. Department of Cancer Immunology and AIDS; Dana-Farber Cancer Institute and Department of Pathology; Harvard Medical School; Boston, MA USA.

PMID: 26989766 PMCID: PMC4792032 DOI: 10.1080/23723556.2015.1030536

Abstract

Cell surface transmembrane protein IGFS8 (herein called EWI-2) negatively regulates melanoma TGF-β signaling and is well positioned to control the transition in TGF-β signaling from cytostatic (in early melanoma stages) to pro-invasion/metastasis (in later stages). EWI-2 functions by sequestering the tetraspanin proteins CD9 and CD81, thereby making them unavailable to support the association of TGFβ receptor 1 with TGFβ receptor 2.

Keywords: CD81; CD9; EWI-2/IGSF8; TGF-β1; melanoma; tetraspanins

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