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Kawaguchi K, Senga S, Kubota C, et al. High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells. FEBS Open Bio. 2016;6(3):190-9doi: 10.1002/2211-5463.12031.
Kawaguchi, K., Senga, S., Kubota, C., Kawamura, Y., Ke, Y., & Fujii, H. (2016). High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells. FEBS open bio, 6(3), 190-9. https://doi.org/10.1002/2211-5463.12031
Kawaguchi, Koichiro, et al. "High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells." FEBS open bio vol. 6,3 (2016): 190-9. doi: https://doi.org/10.1002/2211-5463.12031
Kawaguchi K, Senga S, Kubota C, Kawamura Y, Ke Y, Fujii H. High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells. FEBS Open Bio. 2016 Feb 11;6(3):190-9. doi: 10.1002/2211-5463.12031. eCollection 2016 Mar. PMID: 27047747; PMCID: PMC4794781.
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FEBS Open Bio. 2016 Feb 11;6(3):190-9. doi: 10.1002/2211-5463.12031. eCollection 2016 Mar.

High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells.

FEBS open bio

Koichiro Kawaguchi, Shogo Senga, Chiaki Kubota, Yuki Kawamura, Youqiang Ke, Hiroshi Fujii

Affiliations

  1. Interdisciplinary Graduate School of Science and Technology Shinshu University Minami-minowa Kami-ina Nagano Japan.
  2. Department of Bioscience and Biotechnology Faculty of Agriculture Shinshu University Minami-minowa Kami-ina Nagano Japan.
  3. Molecular Pathology Laboratory Department of Molecular and Clinical Cancer Medicine The University of Liverpool UK.
  4. Interdisciplinary Graduate School of Science and Technology Shinshu University Minami-minowa Kami-ina Nagano Japan; Department of Bioscience and Biotechnology Faculty of Agriculture Shinshu University Minami-minowa Kami-ina Nagano Japan; Department of Interdisciplinary Genome Sciences and Cell Metabolism Institute for Biomedical Sciences Interdisciplinary Cluster for Cutting-Edge Research Shinshu University Minami-minowa Kami-ina Nagano Japan.

PMID: 27047747 PMCID: PMC4794781 DOI: 10.1002/2211-5463.12031

Abstract

Fatty acid-binding proteins (FABPs) are responsible for binding and storing hydrophobic ligands such as long-chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonstrates that the FABP5 gene is upregulated in colorectal cancer cells compared to normal colon cells in a manner that correlates with disease stage and that FABP5 significantly promotes colorectal cancer cell growth and metastatic potential. Thus, FABP5 might be a promising prognostic or therapeutic biomarker candidate in human colorectal cancer.

Keywords: FABP5; colorectal cancer; fatty acid; fatty acid‐binding proteins; lipid metabolism; metastasis

References

  1. Cell Signal. 2011 Dec;23 (12 ):2039-50 - PubMed
  2. Int J Oncol. 2014 Jan;44(1):265-75 - PubMed
  3. Nature. 2012 Nov 15;491(7424):364-73 - PubMed
  4. Annu Rev Nutr. 2008;28:73-95 - PubMed
  5. J Dermatol Sci. 1997 Nov;16(1):17-22 - PubMed
  6. Cell Mol Life Sci. 2002 Jul;59(7):1096-116 - PubMed
  7. Int J Oncol. 2008 Apr;32(4):767-75 - PubMed
  8. Cell. 2010 Jan 8;140(1):49-61 - PubMed
  9. Oncol Rep. 2012 Oct;28(4):1283-92 - PubMed
  10. Oncogene. 2003 May 8;22(18):2739-49 - PubMed
  11. Cancer Lett. 1993 Aug 16;72(1-2):39-44 - PubMed
  12. Mol Pharmacol. 2010 Sep;78(3):419-30 - PubMed
  13. Carcinogenesis. 2007 Dec;28(12):2641-9 - PubMed
  14. Electrophoresis. 1999 Oct;20(14):2952-60 - PubMed
  15. Genes Cancer. 2013 Jul;4(7-8):297-314 - PubMed
  16. Biochim Biophys Acta. 2005 Apr 5;1728(1-2):95-104 - PubMed
  17. PLoS One. 2013 Apr 08;8(4):e60715 - PubMed
  18. Genes Dev. 1999 Jun 15;13(12):1501-12 - PubMed
  19. Int J Oncol. 2008 Jan;32(1):153-9 - PubMed
  20. FEBS J. 2012 Aug;279(15):2610-23 - PubMed
  21. Clin Cancer Res. 2006 Sep 1;12(17):5090-5 - PubMed
  22. Am J Pathol. 2011 Mar;178(3):997-1008 - PubMed
  23. J Biol Chem. 2010 Oct 22;285(43):32679-83 - PubMed
  24. Cancer Res. 2001 Jun 1;61(11):4357-64 - PubMed
  25. Annu Rev Pathol. 2011;6:479-507 - PubMed
  26. N Engl J Med. 2009 Dec 17;361(25):2449-60 - PubMed
  27. Cancer Res. 2000 May 1;60(9):2390-8 - PubMed
  28. Cancer Res. 2013 Aug 1;73(15):4770-80 - PubMed
  29. Cell Metab. 2013 Aug 6;18(2):153-61 - PubMed
  30. PPAR Res. 2010;2010:null - PubMed
  31. Proteomics. 2005 Apr;5(5):1411-22 - PubMed
  32. J Oral Pathol Med. 2010 Apr;39(4):342-8 - PubMed
  33. J Biol Chem. 2010 Jun 18;285(25):19106-15 - PubMed
  34. Cancer Res. 2006 Apr 15;66(8):4394-401 - PubMed
  35. Nature. 2002 Oct 17;419(6908):729-34 - PubMed
  36. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 - PubMed
  37. J Int Med Res. 2011;39(2):533-40 - PubMed
  38. Hum Genomics. 2011 Mar;5(3):170-91 - PubMed
  39. Biomed Chromatogr. 2013 Apr;27(4):440-50 - PubMed
  40. Mol Cell. 2002 Oct;10(4):721-33 - PubMed
  41. Oncotarget. 2015 Mar 20;6(8):6373-85 - PubMed
  42. Cancer Res. 2007 Oct 1;67(19):9039-46 - PubMed

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