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Umehara T, Okita Y, Nonaka M, et al. A case of pilocytic astrocytoma requiring tumor resection during pregnancy. Mol Clin Oncol. 2016;4(4):567-570doi: 10.3892/mco.2016.773.
Umehara, T., Okita, Y., Nonaka, M., Kanemura, Y., Kodama, Y., Mano, M., Nakajima, S., & Fujinaka, T. (2016). A case of pilocytic astrocytoma requiring tumor resection during pregnancy. Molecular and clinical oncology, 4(4), 567-570. https://doi.org/10.3892/mco.2016.773
Umehara, Toru, et al. "A case of pilocytic astrocytoma requiring tumor resection during pregnancy." Molecular and clinical oncology vol. 4,4 (2016): 567-570. doi: https://doi.org/10.3892/mco.2016.773
Umehara T, Okita Y, Nonaka M, Kanemura Y, Kodama Y, Mano M, Nakajima S, Fujinaka T. A case of pilocytic astrocytoma requiring tumor resection during pregnancy. Mol Clin Oncol. 2016 Apr;4(4):567-570. doi: 10.3892/mco.2016.773. Epub 2016 Feb 09. PMID: 27073664; PMCID: PMC4812212.
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Mol Clin Oncol. 2016 Apr;4(4):567-570. doi: 10.3892/mco.2016.773. Epub 2016 Feb 09.

A case of pilocytic astrocytoma requiring tumor resection during pregnancy.

Molecular and clinical oncology

Toru Umehara, Yoshiko Okita, Masahiro Nonaka, Yonehiro Kanemura, Yoshinori Kodama, Masayuki Mano, Shin Nakajima, Toshiyuki Fujinaka

Affiliations

  1. Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.
  2. Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan; Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.
  3. Department of Central Laboratory and Surgical Pathology, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.

PMID: 27073664 PMCID: PMC4812212 DOI: 10.3892/mco.2016.773

Abstract

Low-grade glioma (LGG) is often encountered in relatively young individuals, including women of childbearing age. Notably, case series describing pregnant women with LGG have been reported in the literature. The present study reported a case of pilocytic astrocytoma (PA) requiring tumor resection during pregnancy. The patient had a history of γ-knife radiotherapy for a brainstem tumor 17 years previously. The histological diagnosis was unclear. The tumor had remained stable following radiosurgery for 17 years, including during her first pregnancy. However, rapid tumor growth around the fourth ventricle occurred at week 25 of her second pregnancy. Therefore, an urgent tumor resection was performed despite the pregnancy. Partial resection was performed since the tumor had infiltrated the brainstem. The histological diagnosis was PA. The residual tumor volume decreased gradually following the delivery. Immunostaining of the tumor for the expression of progesterone receptor revealed focal staining. It is possible that reproductive factors, including specific hormonal changes during pregnancy, affected the tumor growth. The present study described this rare case of PA, which exhibited rapid growth and required urgent surgery during pregnancy.

Keywords: pilocytic astrocytoma; pregnancy; tumor growth

References

  1. J Clin Neurosci. 1996 Oct;3(4):334-7 - PubMed
  2. J Neurol. 2009 Dec;256(12):2014-20 - PubMed
  3. Am J Obstet Gynecol. 2000 May;182(5):1215-21 - PubMed
  4. J Neurosurg. 2009 Dec;111(6):1150-7 - PubMed
  5. Obstet Gynecol. 1997 Jan;89(1):19-23 - PubMed
  6. Anticancer Res. 2008 Mar-Apr;28(2A):1055-60 - PubMed
  7. J Neurol Neurosurg Psychiatry. 1986 Aug;49(8):874-80 - PubMed
  8. Nutr Rev. 2005 Apr;63(4):103-10 - PubMed
  9. Cancer. 2008 Dec 15;113(12):3349-54 - PubMed
  10. Cancer. 1997 Dec 1;80(11):2133-40 - PubMed
  11. J Neurooncol. 2013 Nov;115(2):293-301 - PubMed
  12. J Neurooncol. 2014 Jan;116(1):113-7 - PubMed
  13. J Neuropathol Exp Neurol. 2005 Oct;64(10):891-901 - PubMed
  14. Int J Radiat Oncol Biol Phys. 1995 Jun 15;32(3):823-30 - PubMed
  15. Br J Neurosurg. 2011 Apr;25(2):225-30 - PubMed
  16. Rev Neurol (Paris). 2006 Mar;162(3):322-9 - PubMed
  17. Ann Neurol. 2010 Mar;67(3):398-404 - PubMed
  18. Endocrine. 2007 Oct;32(2):129-35 - PubMed
  19. Int J Gynaecol Obstet. 2009 Apr;105(1):56-9 - PubMed

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