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Dourado MCN, Laks J, Mograbi D. Functional Status Predicts Awareness in Late-Onset but not in Early-Onset Alzheimer Disease. J Geriatr Psychiatry Neurol. 2016;29(6):313-319doi: 10.1177/0891988716640372.
Dourado, M. C. N., Laks, J., & Mograbi, D. (2016). Functional Status Predicts Awareness in Late-Onset but not in Early-Onset Alzheimer Disease. Journal of geriatric psychiatry and neurology, 29(6), 313-319. https://doi.org/10.1177/0891988716640372
Dourado, Marcia C N, et al. "Functional Status Predicts Awareness in Late-Onset but not in Early-Onset Alzheimer Disease." Journal of geriatric psychiatry and neurology vol. 29,6 (2016): 313-319. doi: https://doi.org/10.1177/0891988716640372
Dourado MCN, Laks J, Mograbi D. Functional Status Predicts Awareness in Late-Onset but not in Early-Onset Alzheimer Disease. J Geriatr Psychiatry Neurol. 2016 Nov;29(6):313-319. doi: 10.1177/0891988716640372. Epub 2016 Jul 08. PMID: 27048588.
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J Geriatr Psychiatry Neurol. 2016 Nov;29(6):313-319. doi: 10.1177/0891988716640372. Epub 2016 Jul 08.

Functional Status Predicts Awareness in Late-Onset but not in Early-Onset Alzheimer Disease.

Journal of geriatric psychiatry and neurology

Marcia C N Dourado, Jerson Laks, Daniel Mograbi

Affiliations

  1. 1 Center for Alzheimer's Disease, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  2. 2 Centre for Studies and Research on Aging, Institute Vital Brazil, Brazil.
  3. 3 Medicine School, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
  4. 4 Postgraduate Program in Translational Biomedicine-Biotrans, Unigranrio University, Rio de Janeiro, Brazil.
  5. 5 Department of Psychology, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.
  6. 6 Department of Psychology, Institute of Psychiatry, King's College London, London, United Kingdom.

PMID: 27048588 DOI: 10.1177/0891988716640372

Abstract

This study aims to assess whether there are differences between the level of awareness in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer disease (LOAD) and to test its association with quality of life (QOL). A consecutive series of 207 people with Alzheimer disease and their caregivers were selected from an outpatient unit. There were no significant differences in awareness. In LOAD, impairment on awareness was predicted by functional level (β = .37, P < .001), self ( P = .006), and informant report of QOL ( P = .010). The predictors of unawareness in EOAD were self ( P = .002) and informant report of QOL ( P < .001). There is a specific profile of functional deficits underlying awareness in people with LOAD. Additionally, reports of EOAD QOL were more strongly related to awareness than in people with LOAD.

Keywords: Alzheimer disease; awareness of disease; early-onset dementia; functionality; late-onset dementia; quality of life

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