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Malunga LN, Eck P, Beta T. Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone. J Nutr Metab. 2016;2016:1932532doi: 10.1155/2016/1932532.
Malunga, L. N., Eck, P., & Beta, T. (2016). Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone. Journal of nutrition and metabolism, 20161932532. https://doi.org/10.1155/2016/1932532
Malunga, Lovemore Nkhata, et al. "Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone." Journal of nutrition and metabolism vol. 2016 (2016): 1932532. doi: https://doi.org/10.1155/2016/1932532
Malunga LN, Eck P, Beta T. Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone. J Nutr Metab. 2016;2016:1932532. doi: 10.1155/2016/1932532. Epub 2016 Mar 17. PMID: 27073693; PMCID: PMC4814672.
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J Nutr Metab. 2016;2016:1932532. doi: 10.1155/2016/1932532. Epub 2016 Mar 17.

Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone.

Journal of nutrition and metabolism

Lovemore Nkhata Malunga, Peter Eck, Trust Beta

Affiliations

  1. Department of Food Science, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
  2. Department of Human Nutrition, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
  3. Department of Food Science, University of Manitoba, Winnipeg, MB, Canada R3T 2N2; Richardson Centre for Functional Foods & Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.

PMID: 27073693 PMCID: PMC4814672 DOI: 10.1155/2016/1932532

Abstract

The effect of feruloylated arabinoxylan mono- and oligosaccharides (FAXmo) on mammalian α-glucosidase and glucose transporters was investigated using human Caco-2 cells, rat intestinal acetone powder, and Xenopus laevis oocytes. The isolated FAXmo from wheat aleurone and corn bran were identified to have degree of polymerization (DP) of 4 and 1, respectively, by HPLC-MS. Both FAXmo extracts were effective inhibitors of sucrase and maltase functions of the α-glucosidase. The IC50 for FAXmo extracts on Caco-2 cells and rat intestinal α-glucosidase was 1.03-1.65 mg/mL and 2.6-6.5 mg/mL, respectively. Similarly, glucose uptake in Caco-2 cells was inhibited up to 40%. The inhibitory effect of FAXmo was dependent on their ferulic acid (FA) content (R = 0.95). Sodium independent glucose transporter 2 (GLUT2) activity was completely inhibited by FAXmo in oocytes injected to express GLUT2. Our results suggest that ferulic acid and feruloylated arabinoxylan mono-/oligosaccharides have potential for use in diabetes management.

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