Display options
Cite
Kim PG, Suh J, Adelman MW, et al. Pure White Cell Aplasia and Necrotizing Myositis. Case Rep Hematol. 2016;2016:4161679doi: 10.1155/2016/4161679.
Kim, P. G., Suh, J., Adelman, M. W., Oduro, K., Williams, E., Brunner, A. M., & Kuter, D. J. (2016). Pure White Cell Aplasia and Necrotizing Myositis. Case reports in hematology, 20164161679. https://doi.org/10.1155/2016/4161679
Kim, Peter Geon, et al. "Pure White Cell Aplasia and Necrotizing Myositis." Case reports in hematology vol. 2016 (2016): 4161679. doi: https://doi.org/10.1155/2016/4161679
Kim PG, Suh J, Adelman MW, Oduro K, Williams E, Brunner AM, Kuter DJ. Pure White Cell Aplasia and Necrotizing Myositis. Case Rep Hematol. 2016;2016:4161679. doi: 10.1155/2016/4161679. Epub 2016 Mar 17. PMID: 27073704; PMCID: PMC4814688.
Copy Download .nbib Format: NLM
Share it on

Case Rep Hematol. 2016;2016:4161679. doi: 10.1155/2016/4161679. Epub 2016 Mar 17.

Pure White Cell Aplasia and Necrotizing Myositis.

Case reports in hematology

Peter Geon Kim, Joome Suh, Max W Adelman, Kwadwo Oduro, Erik Williams, Andrew M Brunner, David J Kuter

Affiliations

  1. Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  2. Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
  3. Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Hematology/Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
  4. Department of Hematology/Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.

PMID: 27073704 PMCID: PMC4814688 DOI: 10.1155/2016/4161679

Abstract

Pure white cell aplasia (PWCA) is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow with intact megakaryopoiesis and erythropoiesis. PWCA has been associated with autoimmune, drug-induced, and viral exposures. Here, we report a case of a 74-year-old female who presented with severe proximal weakness without pain and was found to have PWCA with nonspecific inflammatory necrotizing myositis and acute liver injury on biopsies. These findings were associated with a recent course of azithromycin and her daily use of a statin. Myositis improved on prednisone but PWCA persisted. With intravenous immunoglobulin and granulocyte-colony stimulating factor therapies, her symptoms and neutrophil counts improved and were sustained for months.

References

  1. Rinsho Ketsueki. 1990 Oct;31(10):1726-30 - PubMed
  2. Intern Med. 2009;48(12):1089-91 - PubMed
  3. Nat Rev Immunol. 2013 Mar;13(3):176-89 - PubMed
  4. N Engl J Med. 1983 May 12;308(19):1141-6 - PubMed
  5. Medicine (Baltimore). 2012 Mar;91(2):95-102 - PubMed
  6. Scand J Infect Dis. 2005;37(8):619-620 - PubMed
  7. Br J Haematol. 1996 Oct;95(1):52-6 - PubMed
  8. N Engl J Med. 1986 Mar 6;314(10):624-5 - PubMed
  9. Hepatology. 2010 Dec;52(6):2065-76 - PubMed
  10. Eur J Haematol. 2007 Sep;79(3):271-3 - PubMed
  11. Blood. 1987 Feb;69(2):394-400 - PubMed
  12. Hematology. 2005 Oct;10(5):365-70 - PubMed
  13. N Engl J Med. 1976 Dec 30;295(27):1489-93 - PubMed
  14. Eur J Intern Med. 2006 Oct;17(6):439-40 - PubMed
  15. Am J Gastroenterol. 1994 Feb;89(2):257-62 - PubMed
  16. Am J Clin Pathol. 1988 Feb;89(2):260-3 - PubMed
  17. Arthritis Res Ther. 2011 Mar 18;13(2):209 - PubMed
  18. Am J Gastroenterol. 2005 Jun;100(6):1415-9 - PubMed
  19. Int J Hematol. 2007 Feb;85(2):97-100 - PubMed
  20. Eur J Haematol. 2003 Mar;70(3):186-9 - PubMed
  21. J Clin Invest. 1988 Feb;81(2):538-48 - PubMed
  22. Muscle Nerve. 2014 Jan;49(1):30-4 - PubMed
  23. Blut. 1987 Jan;54(1):63-4 - PubMed
  24. Arthritis Rheum. 2002 Sep;46(9):2384-91 - PubMed
  25. Br J Haematol. 2000 Dec;111(4):1010-22 - PubMed
  26. Muscle Nerve. 2013 Oct;48(4):477-83 - PubMed
  27. Br J Clin Pharmacol. 2009 Sep;68(3):427-34 - PubMed
  28. Pharmacotherapy. 2002 Jun;22(6):783-8 - PubMed
  29. Br J Haematol. 1992 Feb;80(2):160-5 - PubMed
  30. Br J Haematol. 1984 Nov;58(3):554-5 - PubMed
  31. Science. 2015 Jun 5;348(6239):aaa0698 - PubMed
  32. Arch Neurol. 2005 Mar;62(3):442-6 - PubMed

Publication Types