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Coleman MA, Jessup CF, Bridge JA, et al. Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes. 2016;65(5):1328-1340doi: 10.2337/db15-1418.
Coleman, M. A., Jessup, C. F., Bridge, J. A., Overgaard, N. H., Penko, D., Walters, S., Borg, D. J., Galea, R., Forbes, J. M., Thomas, R., Coates, P. T., Grey, S. T., Wells, J. W., & Steptoe, R. J. (2016). Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes, 65(5), 1328-1340. https://doi.org/10.2337/db15-1418
Coleman, Miranda A, et al. "Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection." Diabetes vol. 65,5 (2016): 1328-1340. doi: https://doi.org/10.2337/db15-1418
Coleman MA, Jessup CF, Bridge JA, Overgaard NH, Penko D, Walters S, Borg DJ, Galea R, Forbes JM, Thomas R, Coates PT, Grey ST, Wells JW, Steptoe RJ. Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes. 2016 May;65(5):1328-1340. doi: 10.2337/db15-1418. Epub 2016 Mar 09. PMID: 26961116.
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Diabetes. 2016 May;65(5):1328-1340. doi: 10.2337/db15-1418. Epub 2016 Mar 09.

Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection.

Diabetes

Miranda A Coleman, Claire F Jessup, Jennifer A Bridge, Nana H Overgaard, Daniella Penko, Stacey Walters, Danielle J Borg, Ryan Galea, Josephine M Forbes, Ranjeny Thomas, Patrick T C Coates, Shane T Grey, James W Wells, Raymond J Steptoe

Affiliations

  1. The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, AUSTRALIA.
  2. Discipline of Medicine, University of Adelaide, Adelaide SA, AUSTRALIA Department of Anatomy & Histology, Flinders University, SA, AUSTRALIA.
  3. Discipline of Medicine, University of Adelaide, Adelaide SA, AUSTRALIA.
  4. Garvan Institute of Medical Research, Sydney, NSW, AUSTRALIA.
  5. Mater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, AUSTRALIA.
  6. The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, AUSTRALIA. [email protected].

PMID: 26961116 DOI: 10.2337/db15-1418

Abstract

Islet-specific memory T cells arise early in type 1 diabetes (T1D), persist for long periods, perpetuate disease and are rapidly reactivated by islet transplantation. As memory T cells are poorly controlled by 'conventional' therapies, memory T-cell mediated attack is a substantial challenge in islet transplantation and this will extend to application of personalized approaches using stem-cell derived replacement β cells. New approaches are required to limit memory autoimmune attack of transplanted islets or replacement β cells. Here we show that transfer of bone marrow encoding cognate antigen directed to dendritic cells, under mild, immune-preserving conditions inactivates established memory CD8

© 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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