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Flick AC, Ding HX, Leverett CA, et al. Synthetic approaches to the 2014 new drugs. Bioorg Med Chem. 2016;24(9):1937-80doi: 10.1016/j.bmc.2016.03.004.
Flick, A. C., Ding, H. X., Leverett, C. A., Kyne, R. E., Liu, K. K., Fink, S. J., & O'Donnell, C. J. (2016). Synthetic approaches to the 2014 new drugs. Bioorganic & medicinal chemistry, 24(9), 1937-80. https://doi.org/10.1016/j.bmc.2016.03.004
Flick, Andrew C, et al. "Synthetic approaches to the 2014 new drugs." Bioorganic & medicinal chemistry vol. 24,9 (2016): 1937-80. doi: https://doi.org/10.1016/j.bmc.2016.03.004
Flick AC, Ding HX, Leverett CA, Kyne RE, Liu KK, Fink SJ, O'Donnell CJ. Synthetic approaches to the 2014 new drugs. Bioorg Med Chem. 2016 May 01;24(9):1937-80. doi: 10.1016/j.bmc.2016.03.004. Epub 2016 Mar 09. PMID: 27020685.
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Bioorg Med Chem. 2016 May 01;24(9):1937-80. doi: 10.1016/j.bmc.2016.03.004. Epub 2016 Mar 09.

Synthetic approaches to the 2014 new drugs.

Bioorganic & medicinal chemistry

Andrew C Flick, Hong X Ding, Carolyn A Leverett, Robert E Kyne, Kevin K-C Liu, Sarah J Fink, Christopher J O'Donnell

Affiliations

  1. Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: [email protected].
  2. Pharmacodia (Beijing) Co., Ltd, Beijing 100085, China. Electronic address: [email protected].
  3. Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: [email protected].
  4. Celgene Avilomics Research, 200 Cambridge Park Drive, Cambridge, MA 02140, United States. Electronic address: [email protected].
  5. China Novartis Institutes for BioMedical Research Co., Ltd, Shanghai 200131, China. Electronic address: [email protected].
  6. BioDuro Co., Ltd, Shanghai 200131, China. Electronic address: [email protected].
  7. Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: [email protected].

PMID: 27020685 DOI: 10.1016/j.bmc.2016.03.004

Abstract

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition and also serve as leads for designing future new drugs. This annual review covers the synthesis of thirty-seven NCEs that were approved for the first time in 2014 and one drug which was approved in 2013 and was not covered in a previous edition of this review.

Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords: Medicine; New chemical entities; New drug molecules; Synthesis; Therapeutic agents

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