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Gutkowska J, Aliou Y, Lavoie JL, et al. Oxytocin decreases diurnal and nocturnal arterial blood pressure in the conscious unrestrained spontaneously hypertensive rat. Pathophysiology. 2016;23(2):111-21doi: 10.1016/j.pathophys.2016.03.003.
Gutkowska, J., Aliou, Y., Lavoie, J. L., Gaab, K., Jankowski, M., & Broderick, T. L. (2016). Oxytocin decreases diurnal and nocturnal arterial blood pressure in the conscious unrestrained spontaneously hypertensive rat. Pathophysiology : the official journal of the International Society for Pathophysiology, 23(2), 111-21. https://doi.org/10.1016/j.pathophys.2016.03.003
Gutkowska, Jolanta, et al. "Oxytocin decreases diurnal and nocturnal arterial blood pressure in the conscious unrestrained spontaneously hypertensive rat." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 23,2 (2016): 111-21. doi: https://doi.org/10.1016/j.pathophys.2016.03.003
Gutkowska J, Aliou Y, Lavoie JL, Gaab K, Jankowski M, Broderick TL. Oxytocin decreases diurnal and nocturnal arterial blood pressure in the conscious unrestrained spontaneously hypertensive rat. Pathophysiology. 2016 Jun;23(2):111-21. doi: 10.1016/j.pathophys.2016.03.003. Epub 2016 Mar 17. PMID: 27020751.
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Pathophysiology. 2016 Jun;23(2):111-21. doi: 10.1016/j.pathophys.2016.03.003. Epub 2016 Mar 17.

Oxytocin decreases diurnal and nocturnal arterial blood pressure in the conscious unrestrained spontaneously hypertensive rat.

Pathophysiology : the official journal of the International Society for Pathophysiology

Jolanta Gutkowska, Yessoufou Aliou, Julie L Lavoie, Katie Gaab, Marek Jankowski, Tom L Broderick

Affiliations

  1. Cardiovascular Biochemistry Laboratory, Centre de Recherché du Centre Hospitalier de l 'Université de Montréal, Montréal, Québec, Canada; Département de Medecine, Université de Montréal, Montreal, Quebec, Canada.
  2. Cardiovascular Biochemistry Laboratory, Centre de Recherché du Centre Hospitalier de l 'Université de Montréal, Montréal, Québec, Canada; Département de Pharmacologie, Université de Montréal, Montreal, Quebec, Canada.
  3. Cardiovascular Biochemistry Laboratory, Centre de Recherché du Centre Hospitalier de l 'Université de Montréal, Montréal, Québec, Canada; Department de Kinesiologie, Université de Montréal, Montreal, Quebec, Canada.
  4. Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, Midwestern University, Glendale, AZ, USA.
  5. Department of Physiology, Laboratory of Diabetes and Exercise Metabolism, Midwestern University, Glendale, AZ, USA. Electronic address: [email protected].

PMID: 27020751 DOI: 10.1016/j.pathophys.2016.03.003

Abstract

In this study, we assessed the effects of oxytocin (OT) on mean arterial blood pressure (MAP), heart rate (HR), and locomotor activity (LA) in male spontaneous hypertensive rats (SHR) and Sprague-Dawley (SDR) controls using telemetry. OT was given by intravenous injections of 0.1, 0.2 or 0.4mg/kg to assess short term acute effects or by daily subcutaneous injections of 0.5 or 1.0mg/kg for 5 days. Compared to the saline infusion, (i) intravenous OT, regardless of concentration, increased MAP in SHR and SDR, (ii) HR increased, but was periodically lower in both strains with 0.2 or 0.4mg/kg, and (iii) no effects of OT on LA were observed. Subcutaneous injections demonstrated that (i) 1.0mg/kg for 5days lowered diurnal MAP and HR in SDR and SHR, persisting for 6 days, (ii) 1.0mg/kg decreased nocturnal HR in SDR, (iii) 0.5 and 1.0mg/kg decreased MAP with minor effects on HR in the SHR, and lastly (iv) OT decreased LA mainly during the diurnal cycle in both strains. Our main results show that OT induces significant beneficial effects on cardiovascular function over several diurnal and nocturnal cycles in the SHR, with the most prominent effect being a robust decrease in MAP.

Copyright © 2016 Elsevier B.V. All rights reserved.

Keywords: Arterial blood pressure; Heart rate; Oxytocin; Radiotelemetry; SHR

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