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Malas MB, Qazi U, Lazarus G, et al. Comparative effectiveness of surgical interventions aimed at treating underlying venous pathology in patients with chronic venous ulcer. J Vasc Surg Venous Lymphat Disord. 2013;2(2):212-25doi: 10.1016/j.jvsv.2013.10.002.
Malas, M. B., Qazi, U., Lazarus, G., Valle, M. F., Wilson, L. M., Haberl, E. B., Bass, E. B., & Zenilman, J. (2014). Comparative effectiveness of surgical interventions aimed at treating underlying venous pathology in patients with chronic venous ulcer. Journal of vascular surgery. Venous and lymphatic disorders, 2(2), 212-25. https://doi.org/10.1016/j.jvsv.2013.10.002
Malas, Mahmoud B, et al. "Comparative effectiveness of surgical interventions aimed at treating underlying venous pathology in patients with chronic venous ulcer." Journal of vascular surgery. Venous and lymphatic disorders vol. 2,2 (2014): 212-25. doi: https://doi.org/10.1016/j.jvsv.2013.10.002
Malas MB, Qazi U, Lazarus G, Valle MF, Wilson LM, Haberl EB, Bass EB, Zenilman J. Comparative effectiveness of surgical interventions aimed at treating underlying venous pathology in patients with chronic venous ulcer. J Vasc Surg Venous Lymphat Disord. 2014 Apr;2(2):212-25. doi: 10.1016/j.jvsv.2013.10.002. Epub 2013 Dec 13. PMID: 26993193.
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J Vasc Surg Venous Lymphat Disord. 2014 Apr;2(2):212-25. doi: 10.1016/j.jvsv.2013.10.002. Epub 2013 Dec 13.

Comparative effectiveness of surgical interventions aimed at treating underlying venous pathology in patients with chronic venous ulcer.

Journal of vascular surgery. Venous and lymphatic disorders

Mahmoud B Malas, Umair Qazi, Gerald Lazarus, M Fran Valle, Lisa M Wilson, Elisabeth B Haberl, Eric B Bass, Jonathan Zenilman

Affiliations

  1. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address: [email protected].
  2. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
  3. Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Md.
  4. School of Nursing, University of Maryland, Baltimore, Md.
  5. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md.

PMID: 26993193 DOI: 10.1016/j.jvsv.2013.10.002

Abstract

OBJECTIVE: Chronic venous ulcers (CVUs) remain the leading causes for nonhealing wounds in the lower extremities. Although multilayer compression dressing remains the treatment gold standard, there are various surgical procedures aimed at healing CVUs with little or no evidence on the efficacy of these treatment methods. We conducted a systematic review of the effects of various surgical treatments for CVUs, in terms of ulcer healing rates, complete time to heal, recurrence rates, mortality, pain, and quality of life.

METHODS: We searched MEDLINE, EMBASE, the Cochrane Central Register for Controlled Trials, and the Cumulative Index for Nursing and Allied Health Literature databases from January 1980 through July 2012. We included studies that compared a surgical procedure with multilayer compression therapy or another surgical procedure among patients with CVUs. We also included studies without a comparison group if they were of sufficient quality. Two independent reviewers screened titles, abstracts, and articles for eligibility. Two reviewers extracted data on study design, applicability, results, and quality.

RESULTS: We identified 10,676 citations, of which 22 studies (23 publications) were included. Eight studies (six randomized controlled trials, two cohorts) compared a surgical procedure with compression. Fourteen studies evaluated different surgical interventions. Adding superficial vein ligation and stripping to compression did not improve wound-healing rate. However, the recurrence rate was 50% reduced when surgery corrected the underlying superficial venous pathology (moderate to high strength of evidence [SOE]). Adding subfascial endoscopic perforator surgery with superficial vein surgery to compression does not improve the healing rate of venous ulcers or reduce the recurrence rate except for medial and large ulcers (high SOE). The SOE was insufficient to support a conclusion about the effects of sclerotherapy when added to compression in healing CVUs. There was insufficient evidence on the surgical treatment of CVUs secondary to deep venous reflux and venous obstruction. We are unable to draw conclusions about the effects of surgical procedures on mortality, pain, and quality of life.

CONCLUSIONS: Our ability to draw conclusions on most surgical techniques is limited due to poorly designed and executed studies, with no uniformity of treatment methods, follow-up or reporting, and lack of randomization. We found some evidence to suggest superficial vein ligation and stripping may reduce the risk of wound recurrence, but these surgical techniques are infrequently performed. The newer minimally invasive techniques lack evidence. Randomized controlled trials for the endovenous procedures used today for treating CVUs are needed.

Copyright © 2014 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

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