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Oba T, Ono M, Iesato A, et al. Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review. Onco Targets Ther. 2016;9:1641-6doi: 10.2147/OTT.S88726.
Oba, T., Ono, M., Iesato, A., Hanamura, T., Watanabe, T., Ito, T., Kanai, T., Maeno, K., Ito, K., Tateishi, A., Yoshizawa, A., & Takayama, F. (2016). Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review. OncoTargets and therapy, 91641-6. https://doi.org/10.2147/OTT.S88726
Oba, Takaaki, et al. "Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review." OncoTargets and therapy vol. 9 (2016): 1641-6. doi: https://doi.org/10.2147/OTT.S88726
Oba T, Ono M, Iesato A, Hanamura T, Watanabe T, Ito T, Kanai T, Maeno K, Ito K, Tateishi A, Yoshizawa A, Takayama F. Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review. Onco Targets Ther. 2016 Mar 18;9:1641-6. doi: 10.2147/OTT.S88726. eCollection 2016. PMID: 27051299; PMCID: PMC4807953.
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Onco Targets Ther. 2016 Mar 18;9:1641-6. doi: 10.2147/OTT.S88726. eCollection 2016.

Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review.

OncoTargets and therapy

Takaaki Oba, Mayu Ono, Asumi Iesato, Toru Hanamura, Takayuki Watanabe, Tokiko Ito, Toshiharu Kanai, Kazuma Maeno, Ken-Ichi Ito, Ayako Tateishi, Akihiko Yoshizawa, Fumiyoshi Takayama

Affiliations

  1. Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
  2. Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
  3. Imaging Center, Ichinose Neurosurgical Hospital, Matsumoto, Japan.

PMID: 27051299 PMCID: PMC4807953 DOI: 10.2147/OTT.S88726

Abstract

Lipid-rich carcinoma (LRC) of the breast is a rare breast cancer variant that accounts for <1% of all breast malignancies. It has been reported that LRCs are negative for estrogen receptor. Here, we report a case of LRC of the breast that was strongly positive for estrogen receptor and treated with endocrine adjuvant therapy. A 52-year-old postmenopausal female noticed a lump in her right breast by self-examination and presented to our hospital. Physical examination revealed an elastic 30 mm ×20 mm hard mass in the upper medial part of her right breast. The findings obtained using ultrasonography, mammography, and contrast-enhanced magnetic resonance imaging suggested breast cancer. Core needle biopsy resulted in the diagnosis of invasive carcinoma. The patient underwent mastectomy and sentinel lymph node biopsy. Histopathologically, the tumor cells were abundant in foamy cytoplasm. Because the presence of marked cytoplasmic lipid droplets was confirmed by Sudan IV staining and electron microscopic examination of the tumor and the lipid droplets were negative for periodic acid-Schiff staining, the tumor was diagnosed as an LRC. Immunohistochemically, estrogen and progesterone receptors of the tumor were strongly positive, human epidermal growth factor receptor type 2 was negative, and the ratio of Ki-67-positive cells was ~30%. After surgery, the patient underwent combination chemotherapy with anthracycline, cyclophosphamide, and 5-fluorouracil, followed by docetaxel. Thereafter, the pateint was treated with letrozole and has remained well for 24 months with no signs of recurrence.

Keywords: breast cancer; endocrine therapy; estrogen receptor

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