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Bhar D, RoyBasunia S, Das A, et al. A comparison between intrathecal clonidine and neostigmine as an adjuvant to bupivacaine in the subarachnoid block for elective abdominal hysterectomy operations: A prospective, double-blind and randomized controlled study. Saudi J Anaesth. 2016;10(2):121-6doi: 10.4103/1658-354X.168797.
Bhar, D., RoyBasunia, S., Das, A., Kundu, S. B., Mondal, R. C., Halder, P. S., Mandal, S. K., & Chattopadhyay, S. (2016). A comparison between intrathecal clonidine and neostigmine as an adjuvant to bupivacaine in the subarachnoid block for elective abdominal hysterectomy operations: A prospective, double-blind and randomized controlled study. Saudi journal of anaesthesia, 10(2), 121-6. https://doi.org/10.4103/1658-354X.168797
Bhar, D, et al. "A comparison between intrathecal clonidine and neostigmine as an adjuvant to bupivacaine in the subarachnoid block for elective abdominal hysterectomy operations: A prospective, double-blind and randomized controlled study." Saudi journal of anaesthesia vol. 10,2 (2016): 121-6. doi: https://doi.org/10.4103/1658-354X.168797
Bhar D, RoyBasunia S, Das A, Kundu SB, Mondal RC, Halder PS, Mandal SK, Chattopadhyay S. A comparison between intrathecal clonidine and neostigmine as an adjuvant to bupivacaine in the subarachnoid block for elective abdominal hysterectomy operations: A prospective, double-blind and randomized controlled study. Saudi J Anaesth. 2016 Apr-Jun;10(2):121-6. doi: 10.4103/1658-354X.168797. PMID: 27051359; PMCID: PMC4799600.
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Saudi J Anaesth. 2016 Apr-Jun;10(2):121-6. doi: 10.4103/1658-354X.168797.

A comparison between intrathecal clonidine and neostigmine as an adjuvant to bupivacaine in the subarachnoid block for elective abdominal hysterectomy operations: A prospective, double-blind and randomized controlled study.

Saudi journal of anaesthesia

D Bhar, S RoyBasunia, A Das, S B Kundu, R C Mondal, P S Halder, S K Mandal, S Chattopadhyay

Affiliations

  1. Department of Anaesthesiology, Midnapore Medical College and Hospital, Midnapore, West Bengal, India.
  2. Department of Anaesthesiology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.
  3. Department of Anaesthesiology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
  4. Department of Gynecology and Obstetrics, Midnapore Medical College and Hospital, Midnapore, West Bengal, India.
  5. Department of Gynecology and Obstetrics, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.

PMID: 27051359 PMCID: PMC4799600 DOI: 10.4103/1658-354X.168797

Abstract

BACKGROUND AND AIMS: Adjuvant to the local anesthetic agent has proven benefits when used intrathecally. With regards to intrathecal bupivacaine as control, we have compared in this study the effects of clonidine and neostigmine when co-administered intrathecally with hyperbaric (0.5%) bupivacaine for abdominal hysterectomy.

MATERIALS AND METHODS: This prospective, randomized, double-blind study was conducted from May 2009 to June 2011. A total of 150 patients of American Society of Anaesthesiology grades I and II scheduled for abdominal hysterectomy under spinal anesthesia were randomly allocated into three groups. A volume of 3 ml of 0.5% hyperbaric bupivacaine was respectively added 1 ml solution containing 5% dextrose and 75 mcg of neostigmine in Group N, 1 ml containing 5% dextrose and 30 mcg of clonidine in Group C and 1 ml of 5% dextrose in Group D (control). We compared the sensory and motor block, the surgical condition, the duration of spinal analgesia and the side-effect profile.

RESULTS AND OBSERVATIONS: Sensory and motor blocks and duration of spinal analgesia were significantly increased in both Group C and Group N compared to Group D. More incidences of Nausea and vomiting were observed in Group N compared to other groups. The surgical condition was poorer in Group N compared to Group C.

CONCLUSION: Both intrathecal clonidine and neostigmine increase the bupivacaine-induced spinal block. However, clonidine provides better surgical condition and fewer incidences of nausea and vomiting.

Keywords: Abdominal hysterectomy; clonidine; intrathecal; neostigmine

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