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Otsubo K, Fukumura A, Hirayama M, et al. Hemophagocytic lymphohistiocytosis caused by systemic herpes simplex virus type 1 infection: Successful treatment with dexamethasone palmitate. Pediatr Int. 2016;58(5):390-393doi: 10.1111/ped.12817.
Otsubo, K., Fukumura, A., Hirayama, M., Morimoto, T., Kato, M., & Mochizuki, H. (2016). Hemophagocytic lymphohistiocytosis caused by systemic herpes simplex virus type 1 infection: Successful treatment with dexamethasone palmitate. Pediatrics international : official journal of the Japan Pediatric Society, 58(5), 390-393. https://doi.org/10.1111/ped.12817
Otsubo, Keisuke, et al. "Hemophagocytic lymphohistiocytosis caused by systemic herpes simplex virus type 1 infection: Successful treatment with dexamethasone palmitate." Pediatrics international : official journal of the Japan Pediatric Society vol. 58,5 (2016): 390-393. doi: https://doi.org/10.1111/ped.12817
Otsubo K, Fukumura A, Hirayama M, Morimoto T, Kato M, Mochizuki H. Hemophagocytic lymphohistiocytosis caused by systemic herpes simplex virus type 1 infection: Successful treatment with dexamethasone palmitate. Pediatr Int. 2016 May;58(5):390-393. doi: 10.1111/ped.12817. Epub 2016 Apr 14. PMID: 27076380.
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Pediatr Int. 2016 May;58(5):390-393. doi: 10.1111/ped.12817. Epub 2016 Apr 14.

Hemophagocytic lymphohistiocytosis caused by systemic herpes simplex virus type 1 infection: Successful treatment with dexamethasone palmitate.

Pediatrics international : official journal of the Japan Pediatric Society

Keisuke Otsubo, Akiko Fukumura, Mariko Hirayama, Tsuyoshi Morimoto, Masahiko Kato, Hiroyuki Mochizuki

Affiliations

  1. Department of Pediatrics, Tokai University School of Medicine, Isehara, Japan.

PMID: 27076380 DOI: 10.1111/ped.12817

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory condition resulting from an uncontrolled and ineffective immune response. Here, we report a case of HLH caused by disseminated herpes simplex virus (HSV)-1 infection. The patient was initially treated with prednisolone and high-dose acyclovir. Although liver enzymes, coagulation abnormalities, and inflammatory markers were remarkably improved, the platelet count remained low. Prednisolone was therefore switched to dexamethasone palmitate. Thereafter, the platelet count normalized. Inflammatory markers normalized 30 days after admission and serum HSV-DNA became undetectable on day 41. The patient was discharged on day 91 and no developmental delay was evident at 7 months of age. These findings suggest that dexamethasone palmitate is effective for neonatal HLH.

© 2016 Japan Pediatric Society.

Keywords: acyclovir; dexamethasone palmitate; hemophagocytic lymphohistiocytosis; herpes simplex type I

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