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Brito FG, Langoni H, Silva RC, et al. Canine visceral leishmaniasis in the Northeast Region of Brazil. J Venom Anim Toxins Incl Trop Dis. 2016;22:15doi: 10.1186/s40409-016-0069-4.
Brito, F. G., Langoni, H., Silva, R. C., Rotondano, T. E., Melo, M. A., & Paz, G. S. (2016). Canine visceral leishmaniasis in the Northeast Region of Brazil. The journal of venomous animals and toxins including tropical diseases, 2215. https://doi.org/10.1186/s40409-016-0069-4
Brito, Flávio Gonçalves, et al. "Canine visceral leishmaniasis in the Northeast Region of Brazil." The journal of venomous animals and toxins including tropical diseases vol. 22 (2016): 15. doi: https://doi.org/10.1186/s40409-016-0069-4
Brito FG, Langoni H, Silva RC, Rotondano TE, Melo MA, Paz GS. Canine visceral leishmaniasis in the Northeast Region of Brazil. J Venom Anim Toxins Incl Trop Dis. 2016 Apr 12;22:15. doi: 10.1186/s40409-016-0069-4. eCollection 2016. PMID: 27076813; PMCID: PMC4830077.
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J Venom Anim Toxins Incl Trop Dis. 2016 Apr 12;22:15. doi: 10.1186/s40409-016-0069-4. eCollection 2016.

Canine visceral leishmaniasis in the Northeast Region of Brazil.

The journal of venomous animals and toxins including tropical diseases

Flávio Gonçalves Brito, Helio Langoni, Rodrigo Costa da Silva, Tereza Emmanuelle de Farias Rotondano, Marcia Almeida de Melo, Giselle Souza da Paz

Affiliations

  1. São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo Brazil.
  2. São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo Brazil ; Diagnostic Service in Zoonosis, Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Husbandry, São Paulo State University (UNESP - Univ Estadual Paulista), District of Rubião Junior, s/n, CEP 18.618-970, Botucatu, São Paulo Brazil.
  3. Mississippi State University of Agriculture and Applied Science, Starkville, MS USA.
  4. Federal University of Pernambuco, Pernambuco, Brazil.
  5. Federal University of Campina Grande, Campina Grande, Paraíba Brazil.

PMID: 27076813 PMCID: PMC4830077 DOI: 10.1186/s40409-016-0069-4

Abstract

BACKGROUND: Visceral leishmaniasis (VL) is a zoonosis that affects dogs and other mammals, including humans. Contact with dogs is a major risk factor for humans. This disease is endemic in several regions of Brazil. The aim of this study was to determine the prevalence of Leishmania spp. infection in dogs and to correlate it with possible risk factors.

METHODS: Blood samples were collected from 391 dogs of different ages, breeds, and both genders, coming from Campina Grande, Paraíba state, Brazil. An epidemiological questionnaire was employed in order to identify risk factors associated with the disease. Serological tests were performed using indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA S7®) and polymerase chain reaction.

RESULTS: Leishmania spp. antibodies were detected in 33 (8.4 %) and 17 (4.3 %) dogs according to the indirect immunofluorescence test (IFAT) and enzyme-linked immunosorbent assay (ELISA S7®), respectively. PCR results indicated the presence of L. chagasi DNA in only eight (2 %) blood samples. There was a significant association between reactive animals and contact with animals from different houses (OR = 4.1; p = 0.02).

CONCLUSIONS: It is suggested that CVL may occur in urban areas. Moreover, it is demonstrated that the association among different diagnostic tests may lead to a more accurate identification of positive animals, which might help to improve the disease control and prevent euthanasia in false-positive results.

Keywords: Diagnosis; Dog; Kala-azar; Risk factors; Zoonosis

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