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Turan I, Kitapcioglu G, Tavmergen Goker E, et al. In vitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease. United European Gastroenterol J. 2015;4(2):221-8doi: 10.1177/2050640615597836.
Turan, I., Kitapcioglu, G., Tavmergen Goker, E., Sahin, G., Bor, S. (2016). In vitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease. United European gastroenterology journal, 4(2), 221-8. https://doi.org/10.1177/2050640615597836
Turan, Ilker, et al. "In vitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease." United European gastroenterology journal vol. 4,2 (2016): 221-8. doi: https://doi.org/10.1177/2050640615597836
Turan I, Kitapcioglu G, Tavmergen Goker E, Sahin G, Bor S. In vitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease. United European Gastroenterol J. 2016 Apr;4(2):221-8. doi: 10.1177/2050640615597836. Epub 2015 Jul 24. PMID: 27087950; PMCID: PMC4804367.
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United European Gastroenterol J. 2016 Apr;4(2):221-8. doi: 10.1177/2050640615597836. Epub 2015 Jul 24.

In vitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease.

United European gastroenterology journal

Ilker Turan, Gul Kitapcioglu, Ege Tavmergen Goker, Gulnaz Sahin, Serhat Bor,

Affiliations

  1. Section of Gastroenterology, Ege University School of Medicine, Izmir, Turkey.
  2. Department of Biostatistics, Ege University School of Medicine, Izmir, Turkey.
  3. Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey; Family Planning and Infertility Treatment and Research Center, Ege University School of Medicine, Izmir, Turkey.
  4. Family Planning and Infertility Treatment and Research Center, Ege University School of Medicine, Izmir, Turkey.

PMID: 27087950 PMCID: PMC4804367 DOI: 10.1177/2050640615597836

Abstract

BACKGROUND: Women conceiving following in vitro fertilization (IVF) likely have a variety of risk factors that predispose them to gastroesophageal reflux disease (GERD) in the future.

OBJECTIVE: We aimed to investigate whether pregnancy through IVF may predispose to subsequent GERD compared with pregnancies without IVF. We also evaluate whether twin IVF pregnancies lead to additional risk for having GERD compared with singleton IVF pregnancies.

METHODS: A validated reflux questionnaire was administered to 156 women with singleton (n = 102) or twin (n = 54) IVF birth (IVF group) and 111 women with a naturally conceived singleton birth (control group). All women included in the study were primiparas who had given birth at least 1 year prior to data collection. The diagnosis of GERD was based on the occurrence of typical symptoms (heartburn, regurgitation, or both) at least once a week.

RESULTS: The prevalence of GERD was 13.5% and 4.5% in IVF and control groups (p = 0.015); in the IVF group, this was slightly higher, but not statistically significant, in women with twin compared with singleton pregnancies (14.8% vs. 12.7%, p = 0.749). Logistic regression analysis showed that IVF was strongly associated with subsequent GERD (OR, 3.30; 95% CI 1.20-9.04; p = 0.02).

CONCLUSION: The risk of developing GERD at least 1 year after delivery increased following IVF. Long-term follow-up studies are required to determine whether therapy during pregnancy can prevent this risk.

Keywords: Gastroesophageal reflux disease; heartburn; in vitro fertilization; pregnancy; regurgitation

References

  1. Am J Gastroenterol. 2005 Apr;100(4):759-65 - PubMed
  2. Am J Gastroenterol. 1999 Jun;94(6):1468-71 - PubMed
  3. Aliment Pharmacol Ther. 2005 Nov 1;22(9):749-57 - PubMed
  4. J Gastroenterol Hepatol. 1998 Oct;13(10):1020-6 - PubMed
  5. Am J Gastroenterol. 2007 Nov;102(11):2395-400 - PubMed
  6. Gastroenterology. 1978 Jun;74(6):1233-7 - PubMed
  7. Br J Obstet Gynaecol. 1977 Jun;84(6):439-43 - PubMed
  8. Psychosom Med. 2004 May-Jun;66(3):426-34 - PubMed
  9. Am J Gastroenterol. 1996 Sep;91(9):1745-8 - PubMed
  10. Aliment Pharmacol Ther. 2003 Sep 15;18(6):595-604 - PubMed
  11. Anaesthesia. 1967 Apr;22(2):249-56 - PubMed
  12. Br J Obstet Gynaecol. 1992 Sep;99(9):731-4 - PubMed
  13. Best Pract Res Clin Gastroenterol. 2007;21(5):793-806 - PubMed
  14. Mayo Clin Proc. 1994 Jun;69(6):539-47 - PubMed
  15. Am J Obstet Gynecol. 1981 Jun 15;140(4):420-2 - PubMed
  16. Gut. 2014 Jun;63(6):871-80 - PubMed
  17. Digestion. 1992;51 Suppl 1:59-67 - PubMed
  18. Aliment Pharmacol Ther. 2004 Jan 1;19(1):95-105 - PubMed
  19. Fertil Steril. 1992 Dec;58(6):1158-63 - PubMed
  20. Gastroenterology. 1977 Apr;72(4 Pt 1):666-8 - PubMed
  21. Gastroenterology. 1976 Aug;71(2):232-4 - PubMed
  22. Clin Gastroenterol Hepatol. 2007 Sep;5(9):1035-9 - PubMed
  23. Gastroenterology. 1998 Dec;115(6):1363-73 - PubMed
  24. Am J Gastroenterol. 2006 Aug;101(8):1900-20; quiz 1943 - PubMed
  25. Dis Esophagus. 2004;17(3):228-34 - PubMed
  26. Gastroenterol Clin North Am. 2003 Mar;32(1):235-61 - PubMed
  27. BMC Gastroenterol. 2012 Sep 24;12:131 - PubMed
  28. Can Med Assoc J. 1968 Mar 23;98(12):571-4 - PubMed
  29. Am J Dig Dis. 1976 Nov;21(11):953-6 - PubMed

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