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Margiotta A, Bucci C. Role of Intermediate Filaments in Vesicular Traffic. Cells. 2016;5(2)doi: 10.3390/cells5020020.
Margiotta, A., & Bucci, C. (2016). Role of Intermediate Filaments in Vesicular Traffic. Cells, 5(2), . https://doi.org/10.3390/cells5020020
Margiotta, Azzurra, and Bucci, Cecilia. "Role of Intermediate Filaments in Vesicular Traffic." Cells vol. 5,2 (2016). doi: https://doi.org/10.3390/cells5020020
Margiotta A, Bucci C. Role of Intermediate Filaments in Vesicular Traffic. Cells. 2016 Apr 25;5(2). doi: 10.3390/cells5020020. PMID: 27120621; PMCID: PMC4931669.
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Cells. 2016 Apr 25;5(2). doi: 10.3390/cells5020020.

Role of Intermediate Filaments in Vesicular Traffic.

Cells

Azzurra Margiotta, Cecilia Bucci

Affiliations

  1. Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy. [email protected].
  2. Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy. [email protected].

PMID: 27120621 PMCID: PMC4931669 DOI: 10.3390/cells5020020

Abstract

Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway.

Keywords: endocytosis; exocytosis; intermediate filaments; intracellular trafficking; membrane traffic; mitosis; vimentin

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