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Zhang WK, Tao SS, Li TT, et al. Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo. Food Nutr Res. 2016;60:30849doi: 10.3402/fnr.v60.30849.
Zhang, W. K., Tao, S. S., Li, T. T., Li, Y. S., Li, X. J., Tang, H. B., Cong, R. H., Ma, F. L., & Wan, C. J. (2016). Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo. Food & nutrition research, 6030849. https://doi.org/10.3402/fnr.v60.30849
Zhang, Wei Kevin, et al. "Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo." Food & nutrition research vol. 60 (2016): 30849. doi: https://doi.org/10.3402/fnr.v60.30849
Zhang WK, Tao SS, Li TT, Li YS, Li XJ, Tang HB, Cong RH, Ma FL, Wan CJ. Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo. Food Nutr Res. 2016 Apr 26;60:30849. doi: 10.3402/fnr.v60.30849. eCollection 2016. PMID: 27121041; PMCID: PMC4848392.
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Food Nutr Res. 2016 Apr 26;60:30849. doi: 10.3402/fnr.v60.30849. eCollection 2016.

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo.

Food & nutrition research

Wei Kevin Zhang, Shan-Shan Tao, Ting-Ting Li, Yu-Sang Li, Xiao-Jun Li, He-Bin Tang, Ren-Huai Cong, Fang-Li Ma, Chu-Jun Wan

Affiliations

  1. Department of Pharmacology, College of Pharmacy, South-Central University for Nationalities, Wuhan, PR China.
  2. Department of Pharmacology, College of Pharmacy, South-Central University for Nationalities, Wuhan, PR China; [email protected].
  3. Functional Oil Laboratory Associated by Oil Crops Research Institute, Chinese Academy of Agricultural Sciences and Infinitus (China) Company Ltd., Guangzhou, PR China.
  4. Functional Oil Laboratory Associated by Oil Crops Research Institute, Chinese Academy of Agricultural Sciences and Infinitus (China) Company Ltd., Guangzhou, PR China; [email protected].
  5. Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, PR China.

PMID: 27121041 PMCID: PMC4848392 DOI: 10.3402/fnr.v60.30849

Abstract

BACKGROUND: Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain.

METHODS AND RESULTS: Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree.

CONCLUSIONS: We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.

Keywords: COX-2; allodynia; chronic pain; nutmeg oil; substance P

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