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Sfera A, Cummings M, Osorio C. Dehydration and Cognition in Geriatrics: A Hydromolecular Hypothesis. Front Mol Biosci. 2016;3:18doi: 10.3389/fmolb.2016.00018.
Sfera, A., Cummings, M., & Osorio, C. (2016). Dehydration and Cognition in Geriatrics: A Hydromolecular Hypothesis. Frontiers in molecular biosciences, 318. https://doi.org/10.3389/fmolb.2016.00018
Sfera, Adonis, et al. "Dehydration and Cognition in Geriatrics: A Hydromolecular Hypothesis." Frontiers in molecular biosciences vol. 3 (2016): 18. doi: https://doi.org/10.3389/fmolb.2016.00018
Sfera A, Cummings M, Osorio C. Dehydration and Cognition in Geriatrics: A Hydromolecular Hypothesis. Front Mol Biosci. 2016 May 12;3:18. doi: 10.3389/fmolb.2016.00018. eCollection 2016. PMID: 27252943; PMCID: PMC4860410.
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Front Mol Biosci. 2016 May 12;3:18. doi: 10.3389/fmolb.2016.00018. eCollection 2016.

Dehydration and Cognition in Geriatrics: A Hydromolecular Hypothesis.

Frontiers in molecular biosciences

Adonis Sfera, Michael Cummings, Carolina Osorio

Affiliations

  1. Department of Psychiatry, Loma Linda UniversityLoma Linda, USA; Patton State HospitalPatton, USA.
  2. Patton State Hospital Patton, USA.
  3. Department of Psychiatry, Loma Linda University Loma Linda, USA.

PMID: 27252943 PMCID: PMC4860410 DOI: 10.3389/fmolb.2016.00018

Abstract

Dehydration is one of the ten most frequent diagnoses responsible for the hospital admission of elderly in the United States. It is associated with increased mortality, morbidity and an estimated cost of 1.14 billion per year (Xiao et al., 2004; Schlanger et al., 2010; Pretorius et al., 2013; Frangeskou et al., 2015). Older individuals are predisposed to dehydration encephalopathy as a result of decreased total body water (TBW) and diminished sensation of thirst. We hypothesize that thirst blunting in older individuals is the result of a defective microRNA-6842-3p failing to silence the expression of the vesicular GABA transporters (VGAT) and alpha 7 cholinergic nicotinic receptors in the subfornical organ (SFO) of the hypothalamus. We hypothesize further that resultant dehydration facilitates protein misfolding and aggregation, predisposing to neurocognitive disorders. We completed a search of predicted microRNA targets, utilizing the public domain tool miRDB and found that microRNA-6842-3p modulates the SLC6A1 and CHRNA7 genes both of which were previously hypothesized to inhibit the thirst sensation by their action on SFO. The primary aim of this article is to answer two questions: Can prevention and correction of dehydration in elderly lower age-related cognitive deterioration? Can exosomal miR-6842 in the peripheral blood predict dehydration encephalopathy in elderly?

Keywords: aquaporins; dehydration; extracellular space; protein conformational dynamics; protein folding

References

  1. Nat Nanotechnol. 2012 Feb 26;7(3):197-203 - PubMed
  2. Nature. 2015 Apr 16;520(7547):349-52 - PubMed
  3. Neuroscience. 2016 May 26;323:170-82 - PubMed
  4. Protein Sci. 2004 Jan;13(1):125-33 - PubMed
  5. Mult Scler. 2015 Dec;21(14):1839-46 - PubMed
  6. Eur J Neurosci. 2004 Apr;19(8):2261-9 - PubMed
  7. Brain. 2012 Sep;135(Pt 9):2809-16 - PubMed
  8. J Cell Biochem. 2013 Jan;114(1):111-9 - PubMed
  9. Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1914-20 - PubMed
  10. Prog Brain Res. 2010;183:183-208 - PubMed
  11. Am Fam Physician. 2013 Mar 1;87(5):331-6 - PubMed
  12. Clin Pract. 2011 Mar 31;1(1):e9 - PubMed
  13. Front Neuroanat. 2014 Nov 12;8:130 - PubMed
  14. Immunopharmacol Immunotoxicol. 2014 Jun;36(3):211-23 - PubMed
  15. J Nutr Health Aging. 2015 Jun;19(6):619-27 - PubMed
  16. Brain Res Bull. 2003 Sep 30;61(5):497-504 - PubMed
  17. Glia. 2012 Aug;60(8):1203-14 - PubMed
  18. PLoS Comput Biol. 2009 Aug;5(8):e1000484 - PubMed
  19. Nature. 2012 Jul 5;487(7405):123-7 - PubMed
  20. Neuroimage Clin. 2014 Aug 23;6:166-70 - PubMed
  21. J Neurobiol. 2002 Dec;53(4):641-55 - PubMed
  22. Curr Neuropharmacol. 2010 Jun;8(2):112-21 - PubMed
  23. Crit Care. 2012 Sep 26;16(5):319 - PubMed
  24. Am J Public Health. 1994 Aug;84(8):1265-9 - PubMed
  25. J Gerontol A Biol Sci Med Sci. 2004 Aug;59(8):811-2 - PubMed
  26. Front Mol Neurosci. 2015 Jul 23;8:38 - PubMed
  27. PLoS One. 2012;7(8):e44195 - PubMed
  28. PLoS One. 2013 Dec 27;8(12):e84793 - PubMed
  29. Epilepsy Res. 2013 Jul;105(1-2):30-41 - PubMed
  30. Mol Neurobiol. 2016 Oct;53(8):5300-9 - PubMed
  31. Acta Pharmacol Sin. 2015 Aug;36(8):939-48 - PubMed
  32. Arch Med Res. 2013 May;44(4):251-8 - PubMed
  33. J Neurochem. 2010 May;113(3):637-48 - PubMed
  34. J Am Soc Nephrol. 2008 May;19(5):1015-24 - PubMed
  35. Ann Neurosci. 2011 Jul;18(3):109-12 - PubMed
  36. Endocrinol Metab Clin North Am. 2013 Jun;42(2):349-70 - PubMed
  37. Neurosci Lett. 2016 Feb 12;614:7-15 - PubMed
  38. Neural Plast. 2015;2015:474917 - PubMed
  39. Eur J Neurosci. 2011 Jul;34(1):3-11 - PubMed
  40. Biophys J. 2012 Sep 5;103(5):1097-107 - PubMed
  41. Neurochem Res. 2014 Nov;39(11):2251-61 - PubMed
  42. J Neuroendocrinol. 2003 Aug;15(8):770-7 - PubMed
  43. Neuroscience. 2008 Jun 26;154(3):994-1001 - PubMed
  44. Mech Ageing Dev. 2014 Mar-Apr;136-137:50-8 - PubMed
  45. Neuropsychopharmacology. 2013 Feb;38(3):437-45 - PubMed
  46. Clin Chem Lab Med. 2009;47(6):627-35 - PubMed
  47. Ann Neurol. 2013 Jan;73(1):65-76 - PubMed
  48. Acc Chem Res. 2015 Apr 21;48(4):956-65 - PubMed
  49. Clin Geriatr Med. 1998 Nov;14(4):745-64 - PubMed
  50. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1602-7 - PubMed
  51. Trends Neurosci. 2008 Jan;31(1):37-43 - PubMed
  52. J Chem Phys. 2011 Feb 28;134(8):085107 - PubMed
  53. Front Psychiatry. 2014 May 26;5:57 - PubMed
  54. PLoS Comput Biol. 2012;8(3):e1002421 - PubMed
  55. Am J Physiol Regul Integr Comp Physiol. 2003 Dec;285(6):R1355-65 - PubMed
  56. Handb Exp Pharmacol. 2009;(190):159-70 - PubMed
  57. J Zhejiang Univ Sci B. 2005 Jan;6(1):33-7 - PubMed
  58. PLoS One. 2012;7(11):e51124 - PubMed
  59. J Neural Transm (Vienna). 2007 Jan;114(1):49-75 - PubMed
  60. Annu Rev Biophys Biomol Struct. 2006;35:389-415 - PubMed
  61. Clin Geriatr Med. 2013 Feb;29(1):101-36 - PubMed
  62. J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):990-2 - PubMed
  63. Physiol Rev. 2013 Oct;93(4):1543-62 - PubMed
  64. Trends Neurosci. 2014 Nov;37(11):620-8 - PubMed
  65. Am J Health Syst Pharm. 2004 Dec 1;61(23):2534-40 - PubMed
  66. Neurosci Lett. 1999 Aug 6;270(3):145-8 - PubMed
  67. ACSMs Health Fit J. 2013 Nov;17(6):21-28 - PubMed
  68. Adv Chronic Kidney Dis. 2010 Jul;17(4):308-19 - PubMed
  69. EMBO Rep. 2005 Dec;6(12):1131-6 - PubMed
  70. J Pept Sci. 2014 Oct;20(10):747-59 - PubMed
  71. J Neuropathol Exp Neurol. 2010 Dec;69(12):1201-9 - PubMed
  72. Acta Neuropathol. 2005 Sep;110(3):281-8 - PubMed
  73. Prion. 2015;9(1):10-21 - PubMed
  74. J Neurovirol. 2005 Dec;11(6):535-43 - PubMed
  75. Int J Mol Sci. 2013 Jul 12;14(7):14575-93 - PubMed
  76. Science. 2013 Oct 18;342(6156):373-7 - PubMed
  77. PLoS One. 2013 Apr 11;8(4):e60553 - PubMed
  78. Life Sci. 2014 Apr 1;100(2):97-109 - PubMed
  79. J Theor Biol. 2014 Dec 21;363:169-87 - PubMed
  80. Annu Rev Genomics Hum Genet. 2006;7:103-24 - PubMed

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