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Juang JM, Chen CY, Liu YB, et al. Prevalence of Atrial Fibrillation in Patients with Brugada Syndrome in Taiwan. Acta Cardiol Sin. 2013;29(4):311-6
Juang, J. M., Chen, C. Y., Liu, Y. B., Lin, L. Y., Chen, W. J., Lai, L. P., Tsai, C. T., & Lin, J. L. (2013). Prevalence of Atrial Fibrillation in Patients with Brugada Syndrome in Taiwan. Acta Cardiologica Sinica, 29(4), 311-6.
Juang, Jyh-Ming Jimmy, et al. "Prevalence of Atrial Fibrillation in Patients with Brugada Syndrome in Taiwan." Acta Cardiologica Sinica vol. 29,4 (2013): 311-6.
Juang JM, Chen CY, Liu YB, Lin LY, Chen WJ, Lai LP, Tsai CT, Lin JL. Prevalence of Atrial Fibrillation in Patients with Brugada Syndrome in Taiwan. Acta Cardiol Sin. 2013 Jul;29(4):311-6. PMID: 27122723; PMCID: PMC4804896.
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Acta Cardiol Sin. 2013 Jul;29(4):311-6.

Prevalence of Atrial Fibrillation in Patients with Brugada Syndrome in Taiwan.

Acta Cardiologica Sinica

Jyh-Ming Jimmy Juang, Ching-Yu Chen, Yen-Bin Liu, Lian-Yu Lin, Wen-Jone Chen, Ling-Ping Lai, Chia-Ti Tsai, Jiunn-Lee Lin

Affiliations

  1. Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

PMID: 27122723 PMCID: PMC4804896

Abstract

PURPOSE: The aim of this study was to assess the prevalence of atrial fibrillation (AF) in patients with Brugada syndrome (BrS) and their clinical characteristics in Taiwan.

METHODS: The patient group consisted of 47 symptomatic BrS patients consecutively enrolled from 2000 to 2010. The definition of BrS patients with AF was a BrS patient with at least one episode of AF in a 12-lead electrogram or 24-hour holter (permanent, persistent or paroxysmal) during follow-up, or before diagnosis of BrS.

RESULTS: Six BrS patients were identified with AF, and all of them were male. Two experienced sudden cardiac death (SCD), 2 presented with seizure and 4 with syncope. The mean age at onset of BrS was 47 ± 16 years, similar to those BrS patients without AF (45 ± 14, p = 0.67). Compared to those BrS patients without AF, significantly higher percentages of the BrS patients with AF presented with seizure and documented ventricular tachyarrhythmia (p = 0.02 and 0.03, respectively). Five of them had spontaneous Brugada type I electrogram, similar to those BrS patients without AF (p = 0.9). The SCN5A mutation rate is similar between BrS patients with AF and those without AF (p = 0.69). The prevalence of AF in BrS patients in Taiwan was 12.7% (6/47, 95% confidence interval 0.06-0.19) which is not significantly lower than the 20% prevalence found in the Caucasian population (p = 0.16).

CONCLUSIONS: BrS patients with AF had distinct clinical features from those patients without AF in Taiwan.

KEY WORDS: Atrial fibrillation; Brugada syndrome; Taiwan.

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