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Niemeyer ZL, Milo A, Hickey DP, et al. Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes. Nat Chem. 2016;8(6):610-7doi: 10.1038/nchem.2501.
Niemeyer, Z. L., Milo, A., Hickey, D. P., & Sigman, M. S. (2016). Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes. Nature chemistry, 8(6), 610-7. https://doi.org/10.1038/nchem.2501
Niemeyer, Zachary L, et al. "Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes." Nature chemistry vol. 8,6 (2016): 610-7. doi: https://doi.org/10.1038/nchem.2501
Niemeyer ZL, Milo A, Hickey DP, Sigman MS. Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes. Nat Chem. 2016 Jun;8(6):610-7. doi: 10.1038/nchem.2501. Epub 2016 May 16. PMID: 27219707.
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Nat Chem. 2016 Jun;8(6):610-7. doi: 10.1038/nchem.2501. Epub 2016 May 16.

Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes.

Nature chemistry

Zachary L Niemeyer, Anat Milo, David P Hickey, Matthew S Sigman

Affiliations

  1. Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
  2. Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

PMID: 27219707 DOI: 10.1038/nchem.2501

Abstract

The mechanistic foundation behind the identity of a phosphine ligand that best promotes a desired reaction outcome is often non-intuitive, and thus has been addressed in numerous experimental and theoretical studies. In this work, multivariate correlations of reaction outcomes using 38 different phosphine ligands were combined with classic potentiometric analyses to study a Suzuki reaction, for which the site selectivity of oxidative addition is highly dependent on the nature of the phosphine. These studies shed light on the generality of hypotheses regarding the structural influence of different classes of phosphine ligands on the reaction mechanism(s), and deliver a methodology that should prove useful in future studies of phosphine ligands.

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