Acta Cardiol Sin. 2014 Jan;30(1):29-37.
Sitagliptin Modulates the Electrical and Mechanical Characteristics of Pulmonary Vein and Atrium.
Acta Cardiologica Sinica
Chien-Jung Chang, Ten-Fang Yang, Tin-I Lee, Yao-Chang Chen, Yu-Hsun Kao, Shih-Ann Chen, Yi-Jen Chen
Affiliations
Affiliations
- Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; ; Division of Cardiology, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan;
- Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; ; Division of Cardiovascular Medicine, Department of Internal Medicine, Taipei Medical University and Hospital, Taipei, Taiwan;
- Division of Endocrinology and Metabolism, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan;
- Department of Biomedical Engineering and Institute of Physiology, National Defense Medical Center, Taipei, Taiwan;
- Department of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; ; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;
- Division of Cardiology and Cardiovascular Research Center, Taipei Veterans General Hospital, Taipei, Taiwan;
- Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; ; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
PMID: 27122765
PMCID: PMC4804818
Abstract
BACKGROUND: The pulmonary veins (PVs) and atria are important foci during that period when atrial fibrillation (AF) is generated and maintained. It is well understood that hypertension and diabetes mellitus (DM) are important risk factors for AF. Dipeptidyl peptidase-IV (DPP-4) inhibitors are new agents in the fight against type 2 DM, though they have been found to have several cardiovascular effects. However, it is not clear whether DPP-4 may modulate the electrical and mechanical characteristics in hypertensive atrium or PVs.
METHODS: Conventional microelectrodes were used to record the action potentials (APs) in isolated PVs, right atrium (RA), and left atrium (LA) in Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) with or without sitagliptin (10 mg/kg) for 4 weeks.
RESULTS: WKY (n = 5), SHR (n = 7), sitagliptin-treated WKY (n = 5) and sitagliptin-treated SHR (n = 7) had similar PV or sinoatrial spontaneous beating rates. However, the sitagliptin-treated WKY had fewer sinoatrial-PV beating rate differences than WKY, SHR or sitagliptin-treated SHR. WKY and SHR had shorter 90% (APD90) of RA AP duration than sitagliptin-treated WKY or sitagliptin-treated SHR. In contrast, WKY had longer LA APD90 than sitagliptin- treated WKY, but SHR and sitagliptin-treated SHR had similar LA APD90. Sitagliptin-treated WKY or sitagliptin- treated SHR had larger (RA-LA) APD90 differences than WKY or SHR, respectively. Moreover, as compared to WKY the post-rest potentiation of contraction was decreased in SHR, sitagliptin-treated WKY, and sitagliptin-treated SHR.
CONCLUSIONS: Sitagliptin significantly affects the electromechanical characteristics of PVs and atria, which can be modulated by hypertension.
KEY WORDS: Atrial fibrillation; Atrium; Dipeptidyl peptidase inhibitor-4; Hypertension; Pulmonary vein.
References
- Am J Cardiol. 2003 May 22;91(10A):9G-14G - PubMed
- Am J Hypertens. 2010 Mar;23(3):334-9 - PubMed
- Cardiovasc Diabetol. 2010 Jan 28;9:6 - PubMed
- Am J Cardiol. 1998 Oct 16;82(8A):2N-9N - PubMed
- Hypertension. 2010 Oct;56(4):728-33 - PubMed
- Blood Press. 2010 Apr;19(2):119-25 - PubMed
- Regul Pept. 2001 Dec 15;102(2-3):81-6 - PubMed
- J Cardiovasc Electrophysiol. 2006 Feb;17(2):220-4 - PubMed
- J Hypertens. 2011 Mar;29(3):520-8 - PubMed
- J Gen Intern Med. 2010 Aug;25(8):853-8 - PubMed
- Cardiovasc Res. 2000 Nov;48(2):265-73 - PubMed
- Circ Heart Fail. 2008 Sep;1(3):153-60 - PubMed
- Expert Rev Cardiovasc Ther. 2012 Mar;10(3):337-51 - PubMed
- Diab Vasc Dis Res. 2004 May;1(1):40-3 - PubMed
- Int Heart J. 2009 Sep;50(5):627-41 - PubMed
- Int J Cardiol. 2013 May 10;165(2):299-307 - PubMed
- Am J Med. 1995 May;98(5):476-84 - PubMed
- Exp Diabetes Res. 2012;2012:635472 - PubMed
- Pharmacotherapy. 2010 May;30(5):463-84 - PubMed
- Int J Cardiol. 2005 Dec 7;105(3):319-21 - PubMed
- Circulation. 2003 Jan 28;107(3):448-54 - PubMed
- Indian J Exp Biol. 2010 Jan;48(1):61-9 - PubMed
- Circ Arrhythm Electrophysiol. 2012 Dec;5(6):1176-83 - PubMed
- J Clin Pharmacol. 2008 May;48(5):592-8 - PubMed
- Eur Heart J. 2006 Dec;27(24):3045-56 - PubMed
- Eur J Pharmacol. 2000 Sep 15;404(1-2):239-45 - PubMed
- J Mol Cell Cardiol. 1993 Sep;25(9):1047-57 - PubMed
- Heart Rhythm. 2010 Sep;7(9):1282-90 - PubMed
- Hypertension. 2003 Feb;41(2):218-23 - PubMed
- J Physiol. 2000 Apr 15;524 Pt 2:415-22 - PubMed
- Cell Calcium. 2005 Sep-Oct;38(3-4):391-6 - PubMed
- BMC Cardiovasc Disord. 2009 Jul 23;9:31 - PubMed
- Int J Cardiol. 2013 Oct 15;168(6):5390-5 - PubMed
- J Clin Invest. 2002 Jul;110(1):43-52 - PubMed
Publication Types