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Liu P, Wu C, Chang X, et al. Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China. Environ Health Perspect. 2016;124(10):1637-1643doi: 10.1289/EHP196.
Liu, P., Wu, C., Chang, X., Qi, X., Zheng, M., & Zhou, Z. (2016). Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China. Environmental health perspectives, 124(10), 1637-1643. https://doi.org/10.1289/EHP196
Liu, Ping, et al. "Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China." Environmental health perspectives vol. 124,10 (2016): 1637-1643. doi: https://doi.org/10.1289/EHP196
Liu P, Wu C, Chang X, Qi X, Zheng M, Zhou Z. Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China. Environ Health Perspect. 2016 Oct;124(10):1637-1643. doi: 10.1289/EHP196. Epub 2016 May 06. PMID: 27153333; PMCID: PMC5047773.
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Environ Health Perspect. 2016 Oct;124(10):1637-1643. doi: 10.1289/EHP196. Epub 2016 May 06.

Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China.

Environmental health perspectives

Ping Liu, Chunhua Wu, Xiuli Chang, Xiaojuan Qi, Minglan Zheng, Zhijun Zhou

Affiliations

  1. School of Public Health/MOE Key Laboratory of Public Health Safety/WHO Collaborating Centre for Occupational Health (Shanghai), Fudan University, Shanghai, China.

PMID: 27153333 PMCID: PMC5047773 DOI: 10.1289/EHP196

Abstract

BACKGROUND: Prenatal exposure to organophosphorous (OP) pesticides has been found to be associated with adverse effects on child neurodevelopment, but evidence on potential effects induced by both prenatal and postnatal OP exposure in infants is limited.

OBJECTIVES: Our aim was to investigate the associations of both prenatal and postnatal OP exposure with birth outcomes and infant neurodevelopment.

METHODS: Exposure to OP in 310 mother-infant pairs was assessed by measuring dimethylphosphate (DM), diethylphosphate (DE), and total dialkylphosphate (DAP) metabolites in urines from pregnant women and their children at 2 years of age. The Gesell Developmental Schedules was administered to examine neurodevelopment of 2-year-old children.

RESULTS: Based on the Gesell Developmental Schedules, the proportions of children with developmental delays were < 6%. Adverse associations between head circumference at birth and prenatal OP exposure were demonstrated. Both prenatal and postnatal OP exposure was significantly associated with increased risk of being developmentally delayed. Specifically, odds ratio (OR) value for prenatal DEs was 9.75 (95% CI: 1.28, 73.98, p = 0.028) in the adaptive area, whereas in the social area, OR values for postnatal DEs and DAPs were 9.56 (95% CI: 1.59, 57.57, p = 0.014) and 12.00 (95% CI: 1.23, 117.37, p = 0.033), respectively. Adverse associations were observed only in boys, not in girls.

CONCLUSIONS: Both prenatal and postnatal OP exposure may adversely affect the neurodevelopment of infants living in the agricultural area. The present study adds to the accumulating evidence on associations of prenatal and postnatal OP exposure with infant neurodevelopment.

CITATION: Liu P, Wu C, Chang X, Qi X, Zheng M, Zhou Z. 2016. Adverse associations of both prenatal and postnatal exposure to organophosphorous pesticides with infant neurodevelopment in an agricultural area of Jiangsu Province, China. Environ Health Perspect 124:1637-1643; http://dx.doi.org/10.1289/EHP196.

Conflict of interest statement

The findings and conclusions in this article are those of the authors and do not necessarily represent the views of Fudan University. The authors declare they have no actual or potential competing fin

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