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Acta Cardiol Sin. 2014 Sep;30(5):401-44.

2014 Guidelines of Taiwan Society of Cardiology (TSOC) for the Management of Pulmonary Arterial Hypertension.

Acta Cardiologica Sinica

Chih-Hsin Hsu, Wan-Jing Ho, Wei-Chun Huang, Yu-Wei Chiu, Tsu-Shiu Hsu, Ping-Hung Kuo, Hsao-Hsun Hsu, Jia-Kan Chang, Chin-Chang Cheng, Chao-Lun Lai, Kae-Woei Liang, Shoa-Lin Lin, Hsao-Hsun Sung, Wei-Chuan Tsai, Ken-Pen Weng, Kai-Sheng Hsieh, Wei-Hsian Yin, Shing-Jong Lin, Kuo-Yang Wang

Affiliations

  1. Department of Internal Medicine, National Cheng Kung University Hospital, Tainan;
  2. Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan;
  3. Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung;
  4. Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City;
  5. Department of Internal Medicine, National Taiwan University Hospital, Taipei;
  6. Department of Surgery, National Taiwan University Hospital, Taipei;
  7. Department of Pediatrics, Cheng-Hsin General Hospital, Taipei;
  8. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu;
  9. Cardiovascular Center, Taichung Veterans General Hospital, Taichung;
  10. Department of Internal Medicine, Yuan's General Hospital, Kaohsiung;
  11. Department of Internal Medicine, Taipei Veterans General Hospital Taipei;
  12. Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung;
  13. Cardiovascular Center, Taichung Veterans General Hospital, Taichung; ; Department of Internal Medicine, Chung-Shan Medical University, Taichung, Taiwan.

PMID: 27122817 PMCID: PMC4824720

Abstract

UNLABELLED: Pulmonary hypertension (PH) is a hemodynamic and pathophysiologic condition, defined as a mean pulmonary arterial pressure exceeding 25 mmHg at rest. According to the recent classifications, it is grouped into pulmonary arterial hypertension (PAH), heart-related, lung-related, thromboembolic, and miscellaneous PH. In the past two decades, tremendous advances have occurred in the field of PH. These include (1) development of clinical diagnostic algorithm and a monitoring strategy dedicated to PAH, (2) defining strong rationales for screening at-risk populations, (3) advent of pulmonary specific drugs which makes PAH manageable, (4) recognition of needs of having proper strategy of combining existing pulmonary specific drugs, and/or potential novel drugs, (5) pursuit of clinical trials with optimal surrogate endpoints and study durations, (6) recognition of critical roles of PH/right ventricular function, as well as interdependence of ventricles in different conditions, especially those with various phenotypes of heart failure, and (7) for rare diseases, putting equal importance on carefully designed observation studies, various registries, etc., besides double blind randomized studies. In addition, ongoing basic and clinical research has led to further understanding of relevant physiology, pathophysiology, epidemiology and genetics of PH/PAH. This guidelines from the working group of Pulmonary Hypertension of the Taiwan Society of Cardiology is to provide updated guidelines based on the most recent international guidelines as well as Taiwan's domestic research on PH. The guidelines are mainly for the management of PAH (Group 1) ; however the majority of content can be helpful for managing other types of PH.

KEY WORDS: Pulmonary arterial hypertension; Taiwan guidelines.

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