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Kao YT, Wang ST, Shih CM, et al. Arterial Stiffness Index and Coronary Artery Plaques in Patients with Subclinical Coronary Atherosclerosis. Acta Cardiol Sin. 2015;31(1):59-65doi: 10.6515/acs20140630b.
Kao, Y. T., Wang, S. T., Shih, C. M., Lin, F. Y., Tsao, N. W., Chiang, K. H., Chan, C. S., Lin, Y. C., Hung, M. Y., Hsieh, M. H., Shyu, K. G., Chen, J. W., Chang, N. C., Yeh, J. S., & Huang, C. Y. (2015). Arterial Stiffness Index and Coronary Artery Plaques in Patients with Subclinical Coronary Atherosclerosis. Acta Cardiologica Sinica, 31(1), 59-65. https://doi.org/10.6515/acs20140630b
Kao, Yung-Ta, et al. "Arterial Stiffness Index and Coronary Artery Plaques in Patients with Subclinical Coronary Atherosclerosis." Acta Cardiologica Sinica vol. 31,1 (2015): 59-65. doi: https://doi.org/10.6515/acs20140630b
Kao YT, Wang ST, Shih CM, Lin FY, Tsao NW, Chiang KH, Chan CS, Lin YC, Hung MY, Hsieh MH, Shyu KG, Chen JW, Chang NC, Yeh JS, Huang CY. Arterial Stiffness Index and Coronary Artery Plaques in Patients with Subclinical Coronary Atherosclerosis. Acta Cardiol Sin. 2015 Jan;31(1):59-65. doi: 10.6515/acs20140630b. PMID: 27122847; PMCID: PMC4804914.
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Acta Cardiol Sin. 2015 Jan;31(1):59-65. doi: 10.6515/acs20140630b.

Arterial Stiffness Index and Coronary Artery Plaques in Patients with Subclinical Coronary Atherosclerosis.

Acta Cardiologica Sinica

Yung-Ta Kao, Sen-Te Wang, Chun-Ming Shih, Feng-Yen Lin, Nai-Wen Tsao, Kuang-Hsing Chiang, Chao-Shun Chan, Yen-Chung Lin, Ming-Yow Hung, Ming-Hsiung Hsieh, Kuo-Gi Shyu, Jaw-Wen Chen, Nen-Chung Chang, Jong-Shiuan Yeh, Chun-Yao Huang

Affiliations

  1. Division of Cardiology, Department of Internal Medicine;
  2. Health Management Center, Taipei Medical University Hospital;
  3. Division of Cardiology, Department of Internal Medicine; ; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University;
  4. Division of Cardiovascular Surgery, Department of Surgery;
  5. Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital;
  6. Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University;
  7. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University; ; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University;
  8. Division of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital; ; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University;
  9. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;
  10. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University; ; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University; ; Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY, USA.

PMID: 27122847 PMCID: PMC4804914 DOI: 10.6515/acs20140630b

Abstract

BACKGROUND: Arterial stiffness is a physiologic quantitative value used to measure arterial compliance. It is predictive of coronary atherosclerosis in patients with intermediate to high cardiovascular risk. However, a correlation between arterial stiffness and subclinical coronary atherosclerosis has yet to be established. Therefore, the purpose of this study was to evaluate arterial stiffness using an arterial stiffness index (ASI) and investigate its association with coronary artery plaque in patients with subclinical coronary atherosclerosis.

METHODS: Our study enrolled 156 consecutive subjects who underwent health screening using a 64-slice cardiac computed tomography angiography (CCTA). Their arterial stiffness index was assessed noninvasively by CardioVision(®) MS-2000. The atheroma on the coronary vessel walls was analyzed.

RESULTS: Of the 156 patients, 53 displayed at least one > 50% stenotic lesion over the coronary arteries in CCTA images. The patients with at least one > 50% coronary stenotic plaque were older and had higher systolic blood pressure and ASI values than patients without > 50% coronary stenotic plaque. After dividing the study population into 2 groups by those patients over and under 50 years of age, the ASI positively correlated with the presentation of at least one > 50% coronary stenotic plaque in patients aged ≥ 50 years (odds ratio = 1.02, 95% confidence interval: 1.00-1.04, p = 0.03).

CONCLUSIONS: The ASI could play a role in risk stratification systems for coronary artery disease in patients with subclinical coronary atherosclerosis, and is a useful clinical marker for the correlation of early coronary plaque.

KEY WORDS: Arterial stiffness; Arterial stiffness index; Atherosclerosis; Coronary artery plaque.

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