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Virchow JC, Akdis CA, Darba J, et al. A review of the value of innovation in inhalers for COPD and asthma. J Mark Access Health Policy. 2015;3doi: 10.3402/jmahp.v3.28760.
Virchow, J. C., Akdis, C. A., Darba, J., Dekhuijzen, R., Hartl, S., Kobelt, G., Roger, A., Simoens, S., Toumi, M., Woodhouse, B., Plich, A., & Torvinen, S. (2015). A review of the value of innovation in inhalers for COPD and asthma. Journal of market access & health policy, 3. https://doi.org/10.3402/jmahp.v3.28760
Virchow, Johann Christian, et al. "A review of the value of innovation in inhalers for COPD and asthma." Journal of market access & health policy vol. 3 (2015). doi: https://doi.org/10.3402/jmahp.v3.28760
Virchow JC, Akdis CA, Darba J, Dekhuijzen R, Hartl S, Kobelt G, Roger A, Simoens S, Toumi M, Woodhouse B, Plich A, Torvinen S. A review of the value of innovation in inhalers for COPD and asthma. J Mark Access Health Policy. 2015 Sep 16;3. doi: 10.3402/jmahp.v3.28760. eCollection 2015. PMID: 27123170; PMCID: PMC4802681.
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J Mark Access Health Policy. 2015 Sep 16;3. doi: 10.3402/jmahp.v3.28760. eCollection 2015.

A review of the value of innovation in inhalers for COPD and asthma.

Journal of market access & health policy

Johann Christian Virchow, Cezmi A Akdis, Josep Darba, Richard Dekhuijzen, Sylvia Hartl, Gisela Kobelt, Albert Roger, Steven Simoens, Mondher Toumi, Ben Woodhouse, Adam Plich, Saku Torvinen

Affiliations

  1. Department of Pneumology/Intensive Care Medicine, University of Rostock, Rostock, Germany.
  2. Christine Kühne-Center for Allergy Research and Education (CK-CARE), Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
  3. Department of Teoria Econòmica, University of Barcelona, Barcelona, Spain.
  4. Department of Pulmonary Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.
  5. Department of Respiratory and Critical Care, Otto Wagner Hospital, Vienna, Austria.
  6. European Health Economics, Mulhouse, France.
  7. Allergy Unit, University Hospital Germans Trias I Pujol, Badalona, Spain.
  8. Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
  9. Department of Public Health, University of Marseilles, Marseille, France.
  10. NHS Bolton Clinical Commissioning Group, Bolton, UK.
  11. TEVA Pharmaceuticals Europe B.V., Amsterdam, The Netherlands.

PMID: 27123170 PMCID: PMC4802681 DOI: 10.3402/jmahp.v3.28760

Abstract

BACKGROUND: Appropriate use of inhaled therapies for asthma and chronic obstructive pulmonary disease (COPD) is critical to ensuring good patient outcomes, efficient use of healthcare resources and limiting the effects of high-morbidity. The appropriate choice of inhaler and active therapy, incorporating patient preferences, can help improve treatment adherence and long-term outcomes. Despite this, many current inhalers are non-intuitive to use, and require extensive training.

METHODS: In this review, an expert panel considers the evidence for the use of inhaler devices in management of COPD and asthma. The panel also evaluates the value of innovation in inhaler technologies, which optimise the use of existing molecules from a clinical, economic and societal perspective.

CONCLUSIONS: The panel conclusion is that there remains a substantial unmet need in inhaler technology and that innovation in inhaler devices can provide real-world health benefits to patients. Furthermore, we recommend that these innovations should be supported by healthcare systems through appropriate pricing and reimbursement mechanisms.

Keywords: Asthma; Chronic obstructive pulmonary disease; adherence; dry powder inhaler; innovation; medication errors; metered dose inhaler; patient compliance; patient preference; value

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