Display options
Cite
Salahshoor MR, Khazaei M, Jalili C, et al. Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice. Int J Fertil Steril. 2016;10(1):71-8doi: 10.22074/ijfs.2016.4771.
Salahshoor, M. R., Khazaei, M., Jalili, C., & Keivan, M. (2016). Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice. International journal of fertility & sterility, 10(1), 71-8. https://doi.org/10.22074/ijfs.2016.4771
Salahshoor, Mohammad Reza, et al. "Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice." International journal of fertility & sterility vol. 10,1 (2016): 71-8. doi: https://doi.org/10.22074/ijfs.2016.4771
Salahshoor MR, Khazaei M, Jalili C, Keivan M. Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice. Int J Fertil Steril. 2016 Apr-Jun;10(1):71-8. doi: 10.22074/ijfs.2016.4771. Epub 2016 Apr 05. PMID: 27123203; PMCID: PMC4845532.
Copy Download .nbib Format: NLM
Share it on

Int J Fertil Steril. 2016 Apr-Jun;10(1):71-8. doi: 10.22074/ijfs.2016.4771. Epub 2016 Apr 05.

Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice.

International journal of fertility & sterility

Mohammad Reza Salahshoor, Mozafar Khazaei, Cyrus Jalili, Mona Keivan

Affiliations

  1. Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

PMID: 27123203 PMCID: PMC4845532 DOI: 10.22074/ijfs.2016.4771

Abstract

BACKGROUND: Crocin, a carotenoid isolated from Crocus sativus L. (saffron), is a pharmacologically active component of saffron. Nicotine consumption can decrease fertility in males through induction of oxidative stress and DNA damage. The aim of this study is to determine the effects of crocin on reproductive parameter damages in male mice exposed to nicotine.

MATERIALS AND METHODS: In this experimental study, we divided 48 mice into 8 groups (n=6 per group): control (normal saline), nicotine (2.5 mg/kg), crocin (12.5, 25 and 50 mg/kg) and crocin (12.5, 25 and 50 mg/kg)+nicotine (2.5 mg/kg). Mice received once daily intraperitoneal injections of crocin, nicotine and crocin+nicotine for 4 weeks. Sperm parameters (count, motility, and viability), testis weight, seminiferous tube diameters, testosterone, and serum nitric oxide levels were analyzed and compared.

RESULTS: Nicotine administration significantly decreased testosterone level; sperm count, viability, and motility; testis weight and seminiferous tubule diameters compared to the control group (P<0.05). However, increasing the dose of crocin in the crocin and crocin+nicotine groups significantly boosted sperm motility and viability; seminiferous tubule diameters; testis weight; and testosterone levels in all groups compared to the nicotine group (P<0.05).

CONCLUSION: Crocin improves nicotine-induced adverse effects on reproductive parameters in male mice.

Keywords: Crocin; Damage; Nicotine; Reproductive

References

  1. Hum Reprod. 2003 Apr;18(4):813-6 - PubMed
  2. Hum Reprod. 2014 May;29(5):1067-75 - PubMed
  3. DNA Cell Biol. 2008 Dec;27(12 ):657-64 - PubMed
  4. Int J Prev Med. 2015 Sep 10;6:92 - PubMed
  5. Urology. 2012 Oct;80(4):822-5 - PubMed
  6. Phytother Res. 2005 Nov;19(11):997-1000 - PubMed
  7. Iran J Reprod Med. 2014 Jun;12(6):401-8 - PubMed
  8. Fertil Steril. 2004 Feb;81(2):349-54 - PubMed
  9. Res Pharm Sci. 2014 Sep-Oct;9(5):351-8 - PubMed
  10. Toxicol Sci. 2010 Aug;116(2):647-59 - PubMed
  11. Singapore Med J. 2007 Feb;48(2):124-30 - PubMed
  12. J Cell Sci. 2010 Mar 15;123(Pt 6):871-80 - PubMed
  13. Pharmacol Rep. 2005 Mar-Apr;57(2):143-53 - PubMed
  14. Niger J Physiol Sci. 2010 Nov 25;25(1):81-6 - PubMed
  15. Biol Reprod. 2000 Nov;63(5):1285-93 - PubMed
  16. Nutr Cancer. 1999;35(2):120-6 - PubMed
  17. Iran J Basic Med Sci. 2013 Jan;16(1):64-72 - PubMed
  18. Exp Oncol. 2007 Sep;29(3):175-80 - PubMed
  19. Toxicol Ind Health. 2015 Apr;31(4):367-76 - PubMed
  20. Int J Prev Med. 2014 May;5(5):563-8 - PubMed
  21. Fertil Steril. 1992 Oct;58(4):750-5 - PubMed
  22. Nephrourol Mon. 2013 Nov 04;6(1):e12125 - PubMed
  23. Phytother Res. 2011 Apr;25(4):508-16 - PubMed
  24. Iran J Basic Med Sci. 2013 Jan;16(1):39-46 - PubMed
  25. Urol Clin North Am. 2014 Feb;41(1):195-204 - PubMed
  26. Adv Biomed Res. 2015 Feb 11;4:40 - PubMed
  27. Phytother Res. 2011 Dec;25(12 ):1833-8 - PubMed

Publication Types