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Chen G, Shao H, Pan X. A randomized controlled trial to compare the effects of liquid versus powdered recombinant human growth hormone in treating patients with severe burns. Biomed Rep. 2016;4(5):551-556doi: 10.3892/br.2016.635.
Chen, G., Shao, H., & Pan, X. (2016). A randomized controlled trial to compare the effects of liquid versus powdered recombinant human growth hormone in treating patients with severe burns. Biomedical reports, 4(5), 551-556. https://doi.org/10.3892/br.2016.635
Chen, Guoxian, et al. "A randomized controlled trial to compare the effects of liquid versus powdered recombinant human growth hormone in treating patients with severe burns." Biomedical reports vol. 4,5 (2016): 551-556. doi: https://doi.org/10.3892/br.2016.635
Chen G, Shao H, Pan X. A randomized controlled trial to compare the effects of liquid versus powdered recombinant human growth hormone in treating patients with severe burns. Biomed Rep. 2016 May;4(5):551-556. doi: 10.3892/br.2016.635. Epub 2016 Mar 22. PMID: 27123246; PMCID: PMC4840508.
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Biomed Rep. 2016 May;4(5):551-556. doi: 10.3892/br.2016.635. Epub 2016 Mar 22.

A randomized controlled trial to compare the effects of liquid versus powdered recombinant human growth hormone in treating patients with severe burns.

Biomedical reports

Guoxian Chen, Huawei Shao, Xuanliang Pan

Affiliations

  1. Department of Burns, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

PMID: 27123246 PMCID: PMC4840508 DOI: 10.3892/br.2016.635

Abstract

Recombinant human growth hormone (rhGH) promotes protein utilization and synthesis, and is widely used as a therapy to treat severe burns. The present randomized controlled trial evaluated the effects of different forms of rhGH on patients with severe burns. A total of 29 adult severe burns patients were enrolled between February 2009 and November 2011, and randomly assigned to either treatment group (T, liquid rhGH) or control group (C, powder rhGH). From days 5 to 7 following the infliction of burns, both patient groups received rhGH at 0.067 mg/kg/d, once for 10 days. Median serum pre-albumin levels increased in both groups following treatment, the elevation from baseline was significantly higher in the T group on day 10 compared to the C group (88 mg/l vs. 65 mg/l, P=0.046). C-reactive protein, fasting plasma glucose and body weight decreased in both groups. Body weight was significantly lower in the T compared to the C group at baseline, Day 5 and Day 10 (P=0.046, P=0.018 and P=0.006, respectively), however the decrease from baseline levels were not significantly different. Wound healing time was similar between groups (P=0.270). In conclusion the early use of liquid rather than powder rhGH may be more beneficial for treating adult patients with severe burns.

Keywords: adult metabolism; burns; dosage forms; pre-albumin; recombinant human growth hormone

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