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Gunton JE, Gates F, Fulcher GR, et al. Bone Mineral Density in Postmenopausal Women Heterozygous for the C282Y HFE Mutation. J Osteoporos. 2016;2016:5638273doi: 10.1155/2016/5638273.
Gunton, J. E., Gates, F., Fulcher, G. R., & Clifton-Bligh, P. B. (2016). Bone Mineral Density in Postmenopausal Women Heterozygous for the C282Y HFE Mutation. Journal of osteoporosis, 20165638273. https://doi.org/10.1155/2016/5638273
Gunton, Jenny E, et al. "Bone Mineral Density in Postmenopausal Women Heterozygous for the C282Y HFE Mutation." Journal of osteoporosis vol. 2016 (2016): 5638273. doi: https://doi.org/10.1155/2016/5638273
Gunton JE, Gates F, Fulcher GR, Clifton-Bligh PB. Bone Mineral Density in Postmenopausal Women Heterozygous for the C282Y HFE Mutation. J Osteoporos. 2016;2016:5638273. doi: 10.1155/2016/5638273. Epub 2016 Mar 31. PMID: 27123357; PMCID: PMC4830734.
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J Osteoporos. 2016;2016:5638273. doi: 10.1155/2016/5638273. Epub 2016 Mar 31.

Bone Mineral Density in Postmenopausal Women Heterozygous for the C282Y HFE Mutation.

Journal of osteoporosis

Jenny E Gunton, Frances Gates, Greg R Fulcher, Phillip B Clifton-Bligh

Affiliations

  1. Westmead Clinical School, Westmead Hospital, Cnr Hawkesbury Road and Darcy Road, Westmead, NSW 2145, Australia.
  2. Department of Endocrinology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
  3. Department of Endocrinology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia; Northern Clinical School, University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.

PMID: 27123357 PMCID: PMC4830734 DOI: 10.1155/2016/5638273

Abstract

Mutations in the HFE gene may be associated with increased tissue iron stores reflected in an elevated serum ferritin. With homozygous mutation C282Y, the increase in serum ferritin may be associated with tissue damage in the liver, pancreas, and pituitary and with a reduced bone mineral density. With heterozygous mutation C282Y, the degree of iron retention is less but information relating to how a heterozygous C282Y mutation might impact bone mineral density is uncertain. The present study was undertaken to study the relationships between bone mineral density measured by dual energy X-ray absorptiometry and the serum ferritin and serum iron in postmenopausal women heterozygous for the C282Y mutation. The spinal bone mineral density, L2-4, was significantly less than age matched community controls (P = 0.016). There was no significant change in the femoral neck bone mineral density compared to age matched community controls. The correlation between the spinal bone mineral density, L2-4, the femoral neck bone mineral density, and the serum ferritin was not significant. The serum iron correlated significantly inversely with the femoral neck bone mineral density (P = 0.048). The heterozygous C282Y mutation may be associated with impairment of bone cell function in postmenopausal women when only small increases in the serum iron or serum ferritin have occurred.

References

  1. J Bone Miner Res. 2011 Jun;26(6):1188-96 - PubMed
  2. J Bone Miner Res. 1988 Dec;3(6):601-4 - PubMed
  3. J Gastroenterol Hepatol. 2015 Apr;30(4):719-25 - PubMed
  4. Nutr Metab Cardiovasc Dis. 2006 Jan;16(1):60-8 - PubMed
  5. J Endocrinol Invest. 2010 Sep;33(8):544-8 - PubMed
  6. J Bone Miner Metab. 2014 Nov;32(6):683-90 - PubMed
  7. Vital Health Stat 11. 2012 Mar;(251):1-132 - PubMed
  8. Blood. 2007 Sep 15;110(6):2182-9 - PubMed
  9. Gut. 1990 Jan;31(1):82-7 - PubMed
  10. PLoS One. 2014 Dec 18;9(12):e114972 - PubMed
  11. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10289-93 - PubMed
  12. Osteoporos Int. 2009 Apr;20(4):549-55 - PubMed
  13. Ann Hematol. 1992 Aug;65(2):96-102 - PubMed
  14. J Rheumatol. 1997 Sep;24(9):1809-13 - PubMed
  15. N Engl J Med. 1996 Dec 12;335(24):1799-805 - PubMed
  16. Rev Rhum Mal Osteoartic. 1979 Feb;46(2):91-9 - PubMed
  17. Osteoporos Int. 2011 Aug;22(8):2313-9 - PubMed
  18. J Bone Miner Res. 1994 Oct;9(10):1503-14 - PubMed
  19. J Bone Miner Res. 2012 Nov;27(11):2279-90 - PubMed
  20. Calcif Tissue Int. 2014 Mar;94(3):353-60 - PubMed
  21. J Bone Miner Res. 1990 Jan;5(1):41-7 - PubMed
  22. South Med J. 2005 Aug;98(8):845 - PubMed
  23. J Gastroenterol Hepatol. 1999 Feb;14(2):176-8 - PubMed
  24. Clin Chem. 2001 Feb;47(2):202-8 - PubMed
  25. Bone. 2008 Dec;43(6):1010-5 - PubMed
  26. Sem Hop. 1960 Dec 20;36:3279-94 - PubMed
  27. Osteoporos Int. 2005 Dec;16(12 ):1809-14 - PubMed
  28. Zhonghua Wai Ke Za Zhi. 2013 Jun 1;51(6):518-21 - PubMed
  29. Biometals. 2006 Jun;19(3):245-51 - PubMed
  30. Am J Hum Genet. 2007 Oct;81(4):799-807 - PubMed
  31. Asia Pac J Clin Nutr. 2008;17(1):40-7 - PubMed

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