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Abaroa-Salvatierra A, Shaikh B, Deshmukh M, et al. Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report. J Community Hosp Intern Med Perspect. 2016;6(2):30381doi: 10.3402/jchimp.v6.30381.
Abaroa-Salvatierra, A., Shaikh, B., Deshmukh, M., Alweis, R., & Patel, A. (2016). Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report. Journal of community hospital internal medicine perspectives, 6(2), 30381. https://doi.org/10.3402/jchimp.v6.30381
Abaroa-Salvatierra, Ana, et al. "Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report." Journal of community hospital internal medicine perspectives vol. 6,2 (2016): 30381. doi: https://doi.org/10.3402/jchimp.v6.30381
Abaroa-Salvatierra A, Shaikh B, Deshmukh M, Alweis R, Patel A. Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report. J Community Hosp Intern Med Perspect. 2016 Apr 25;6(2):30381. doi: 10.3402/jchimp.v6.30381. eCollection 2016. PMID: 27124160; PMCID: PMC4857720.
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J Community Hosp Intern Med Perspect. 2016 Apr 25;6(2):30381. doi: 10.3402/jchimp.v6.30381. eCollection 2016.

Calcitriol-mediated hypercalcemia in a patient with bilateral adrenal non-Hodgkin's B-cell lymphoma case report.

Journal of community hospital internal medicine perspectives

Ana Abaroa-Salvatierra, Bilal Shaikh, Mrunalini Deshmukh, Richard Alweis, Arti Patel

Affiliations

  1. Department of Internal Medicine, Reading Health System, West Reading, PA, USA; [email protected].
  2. Department of Internal Medicine, Reading Health System, West Reading, PA, USA.
  3. Department of Endocrinology and Diabetes Center, Reading Health System, West Reading, PA, USA.

PMID: 27124160 PMCID: PMC4857720 DOI: 10.3402/jchimp.v6.30381

Abstract

Calcitriol-mediated hypercalcemia is a frequent manifestation of hematological malignancies. However, there are a few reports of cases presenting with increased angiotensin-converting enzyme (ACE) level, which suggests a possible mechanism similar to that of granulomatous diseases. We present a patient with hypercalcemia, normal parathyroid hormone, and parathyroid hormone-related protein levels but high calcitriol and ACE levels that, after further investigation, was diagnosed with bilateral adrenal non-Hodgkin's B-cell lymphoma. Primary adrenal lymphoma represents only 1% of all non-Hodgkin's lymphomas and is usually asymptomatic but should be considered by clinicians among the malignancies that cause calcitriol-mediated hypercalcemia.

Keywords: calcitriol-mediated hypercalcemia; non-Hodgkin’s lymphoma; primary adrenal lymphoma

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