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Dismukes AR, Meyer VJ, Shirtcliff EA, et al. Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth. Endocr Connect. 2016;5(3):107-14doi: 10.1530/EC-16-0007.
Dismukes, A. R., Meyer, V. J., Shirtcliff, E. A., Theall, K. P., Esteves, K. C., & Drury, S. S. (2016). Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth. Endocrine connections, 5(3), 107-14. https://doi.org/10.1530/EC-16-0007
Dismukes, Andrew R, et al. "Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth." Endocrine connections vol. 5,3 (2016): 107-14. doi: https://doi.org/10.1530/EC-16-0007
Dismukes AR, Meyer VJ, Shirtcliff EA, Theall KP, Esteves KC, Drury SS. Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth. Endocr Connect. 2016 May;5(3):107-14. doi: 10.1530/EC-16-0007. PMID: 27221260; PMCID: PMC5002957.
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Endocr Connect. 2016 May;5(3):107-14. doi: 10.1530/EC-16-0007.

Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth.

Endocrine connections

Andrew R Dismukes, Vanessa J Meyer, Elizabeth A Shirtcliff, Katherine P Theall, Kyle C Esteves, Stacy S Drury

Affiliations

  1. Department of Human Development and Family StudiesIowa State University, Ames, Iowa, USA Tulane University School of MedicineDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USA.
  2. Department of Human Development and Family StudiesIowa State University, Ames, Iowa, USA.
  3. Tulane University School of MedicineDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USA.
  4. Tulane University School of MedicineDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USA [email protected].

PMID: 27221260 PMCID: PMC5002957 DOI: 10.1530/EC-16-0007

Abstract

The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging.

© 2016 The authors.

Keywords: DHEA; TSST; aging; telomerase; telomere; telomere length

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