Display options
Cite
Martynov MY, Gusev EI. Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke. J Exp Pharmacol. 2015;7:17-28doi: 10.2147/JEP.S63544.
Martynov, M. Y., & Gusev, E. I. (2015). Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke. Journal of experimental pharmacology, 717-28. https://doi.org/10.2147/JEP.S63544
Martynov, Mikhail Yu, and Gusev, Eugeny I. "Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke." Journal of experimental pharmacology vol. 7 (2015): 17-28. doi: https://doi.org/10.2147/JEP.S63544
Martynov MY, Gusev EI. Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke. J Exp Pharmacol. 2015 Oct 01;7:17-28. doi: 10.2147/JEP.S63544. eCollection 2015. PMID: 27186142; PMCID: PMC4863531.
Copy Download .nbib Format: NLM
Share it on

J Exp Pharmacol. 2015 Oct 01;7:17-28. doi: 10.2147/JEP.S63544. eCollection 2015.

Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke.

Journal of experimental pharmacology

Mikhail Yu Martynov, Eugeny I Gusev

Affiliations

  1. Department of Neurology, Neurosurgery and Medical Genetics, Russian National Research Medical University, Moscow, Russia.

PMID: 27186142 PMCID: PMC4863531 DOI: 10.2147/JEP.S63544

Abstract

Ischemic stroke is one of the leading causes of long-lasting disability and death. Two main strategies have been proposed for the treatment of ischemic stroke: restoration of blood flow by thrombolysis or mechanical thrombus extraction during the first few hours of ischemic stroke, which is one of the most effective treatments and leads to a better functional and clinical outcome. The other direction of treatment, which is potentially applicable to most of the patients with ischemic stroke, is neuroprotection. Initially, neuroprotection was mainly targeted at protecting gray matter, but during the past few years there has been a transition from a neuron-oriented approach toward salvaging the whole neurovascular unit using multimodal drugs. Citicoline is a multimodal drug that exhibits neuroprotective and neuroregenerative effects in a variety of experimental and clinical disorders of the central nervous system, including acute and chronic cerebral ischemia, intracerebral hemorrhage, and global cerebral hypoxia. Citicoline has a prolonged therapeutic window and is active at various temporal and biochemical stages of the ischemic cascade. In acute ischemic stroke, citicoline provides neuroprotection by attenuating glutamate exitotoxicity, oxidative stress, apoptosis, and blood-brain barrier dysfunction. In the subacute and chronic phases of ischemic stroke, citicoline exhibits neuroregenerative effects and activates neurogenesis, synaptogenesis, and angiogenesis and enhances neurotransmitter metabolism. Acute and long-term treatment with citicoline is safe and in most clinical studies is effective and improves functional outcome.

Keywords: cell membranes; ischemic stroke; neuroprotection; neuroregeneration; oxidative stress

References

  1. PLoS One. 2011;6(8):e22135 - PubMed
  2. J Clin Neurosci. 2010 Feb;17(2):227-31 - PubMed
  3. Neurology. 1997 Sep;49(3):671-8 - PubMed
  4. Neurobiol Dis. 2005 Mar;18(2):336-45 - PubMed
  5. J Neurosci Res. 1999 Dec 1;58(5):697-705 - PubMed
  6. Curr Drug Metab. 2011 Sep;12(7):611-20 - PubMed
  7. Biochem Pharmacol. 1987 Nov 1;36(21):3697-700 - PubMed
  8. Stroke. 2012 Jul;43(7):1931-40 - PubMed
  9. Mol Pharm. 2013 May 6;10(5):1473-91 - PubMed
  10. Prog Neurobiol. 1995 Aug;46(6):607-36 - PubMed
  11. Neurochem Res. 2013 Aug;38(8):1641-7 - PubMed
  12. Ann N Y Acad Sci. 2000;920:332-5 - PubMed
  13. Neurochem Int. 2012 Feb;60(3):310-7 - PubMed
  14. Cerebrovasc Dis. 2006;21(5-6):380-5 - PubMed
  15. J Neurosci Res. 2003 Aug 1;73(3):308-15 - PubMed
  16. Stroke. 2001 Oct;32(10):2376-81 - PubMed
  17. Int J Neurosci. 2007 Jul;117(7):985-98 - PubMed
  18. Stroke. 1988 Feb;19(2):211-6 - PubMed
  19. FASEB J. 2007 Nov;21(13):3666-76 - PubMed
  20. Stroke. 1999 May;30(5):1150-3 - PubMed
  21. J Biol Chem. 1998 Nov 6;273(45):29745-53 - PubMed
  22. Neurosci Lett. 2013 Oct 11;553:72-7 - PubMed
  23. Rev Neurol Dis. 2008 Fall;5(4):167-77 - PubMed
  24. J Pharmacol Sci. 2011;116(2):232-7 - PubMed
  25. Lancet. 2012 Jul 28;380(9839):349-57 - PubMed
  26. Exp Neurol. 2000 Feb;161(2):733-9 - PubMed
  27. Brain. 1999 Dec;122 ( Pt 12):2387-400 - PubMed
  28. J Cereb Blood Flow Metab. 1992 Mar;12(2):193-203 - PubMed
  29. J Neurosurg. 2000 Mar;92(3):448-52 - PubMed
  30. J Cell Sci. 2009 Apr 15;122(Pt 8):1155-62 - PubMed
  31. PLoS One. 2013 Sep 04;8(9):e73244 - PubMed
  32. J Neurochem. 2012 Oct;123(2):217-25 - PubMed
  33. Stroke. 1996 Apr;27(4):599-606 - PubMed
  34. J Cereb Blood Flow Metab. 2001 Jan;21(1):2-14 - PubMed
  35. Neurobiol Dis. 2007 Apr;26(1):105-11 - PubMed
  36. Brain Res. 1999 Mar 20;822(1-2):52-9 - PubMed
  37. Stroke. 2014 Jan;45(1):224-30 - PubMed
  38. Neurosci Lett. 2002 Jan 25;318(2):103-7 - PubMed
  39. Br J Cancer. 1972 Aug;26(4):239-57 - PubMed
  40. Neuroscience. 2003;118(1):107-13 - PubMed
  41. Neurol Res. 2011 Jul;33(6):572-7 - PubMed
  42. J Neurochem. 1995 Jan;64(1):378-84 - PubMed
  43. Stroke. 1988 Feb;19(2):217-22 - PubMed
  44. Biochim Biophys Acta. 2010 Aug;1804(8):1666-75 - PubMed
  45. Cell. 2005 Oct 21;123(2):321-34 - PubMed
  46. J Neurochem. 1992 Jul;59(1):338-43 - PubMed
  47. Brain Res. 1989 Apr 10;484(1-2):217-27 - PubMed
  48. Neuroscience. 2008 Aug 13;155(2):556-64 - PubMed
  49. Stroke. 1981 Nov-Dec;12(6):723-5 - PubMed
  50. Neuropharmacology. 2008 Sep;55(3):363-89 - PubMed
  51. J Cereb Blood Flow Metab. 1994 Jan;14(1):12-9 - PubMed
  52. PLoS One. 2013 Dec 16;8(12):e82604 - PubMed
  53. Stem Cells. 2010 Mar 31;28(3):545-54 - PubMed
  54. Stroke. 2002 Dec;33(12):2850-7 - PubMed
  55. Neurochem Res. 1981 Aug;6(8):821-33 - PubMed
  56. Cerebrovasc Brain Metab Rev. 1996 Fall;8(3):195-208 - PubMed
  57. J Cereb Blood Flow Metab. 2014 Aug;34(8):1297-305 - PubMed
  58. Br J Pharmacol. 1991 Nov;104(3):575-8 - PubMed
  59. J Neurol Sci. 1996 Jun;138(1-2):21-5 - PubMed
  60. Lancet. 2014 Jan 18;383(9913):245-54 - PubMed
  61. J Lipid Res. 2013 Dec;54(12):3373-84 - PubMed
  62. Methods Find Exp Clin Pharmacol. 2009 Apr;31(3):171-6 - PubMed
  63. J Clin Invest. 2003 Nov;112(10):1533-40 - PubMed
  64. J Neurol Sci. 2006 Sep 25;247(2):121-9 - PubMed
  65. J Mol Neurosci. 2011 Jun;44(2):130-9 - PubMed
  66. J Cereb Blood Flow Metab. 1996 Nov;16(6):1090-9 - PubMed
  67. J Neurochem. 2013 Sep;126(6):819-26 - PubMed
  68. J Mol Neurosci. 2003 Feb;20(1):53-60 - PubMed
  69. Brain Res. 2004 Nov 19;1027(1-2):48-58 - PubMed
  70. Br Med Bull. 1997;53(3):539-53 - PubMed
  71. J Biol Chem. 1956 Sep;222(1):193-214 - PubMed
  72. Neuropharmacology. 2002 May;42(6):846-54 - PubMed
  73. Stroke. 2007 Oct;38(10):2759-64 - PubMed
  74. Stroke. 1997 May;28(5):1060-5 - PubMed
  75. J Cereb Blood Flow Metab. 2007 Mar;27(3):564-74 - PubMed
  76. FASEB J. 1999 Jan;13(1):135-42 - PubMed
  77. Stroke. 2009 May;40(5):e331-9 - PubMed
  78. J Biol Chem. 2003 Aug 22;278(34):31964-71 - PubMed
  79. Am J Physiol Cell Physiol. 2001 Jun;280(6):C1358-66 - PubMed
  80. J Cell Physiol. 2011 Oct;226(10):2484-93 - PubMed
  81. PLoS One. 2013 Jul 23;8(7):e68891 - PubMed
  82. Clin Biochem. 2000 Jul;33(5):351-7 - PubMed
  83. J Neuroinflammation. 2010 Jul 30;7:42 - PubMed
  84. Neuron. 2011 Jun 9;70(5):847-54 - PubMed
  85. J Biol Chem. 2007 Dec 7;282(49):36112-20 - PubMed
  86. Neurobiol Dis. 2008 Jan;29(1):123-31 - PubMed
  87. Cell Biochem Biophys. 2007;47(1):73-86 - PubMed
  88. J Neurochem. 2000 Dec;75(6):2528-35 - PubMed
  89. Transl Stroke Res. 2011 Jun 1;2(2):129-35 - PubMed
  90. Biochem J. 1995 Aug 15;310 ( Pt 1):83-90 - PubMed
  91. Stroke. 2009 Oct;40(10):3390-2 - PubMed
  92. Neuropsychopharmacology. 2010 Apr;35(5):1165-73 - PubMed
  93. J Cereb Blood Flow Metab. 1995 Jul;15(4):566-77 - PubMed
  94. Circulation. 2011 Feb 22;123(7):739-49 - PubMed
  95. Neuron. 1994 Sep;13(3):713-25 - PubMed
  96. Neurology. 2001 Nov 13;57(9):1595-602 - PubMed
  97. Neuron. 2014 May 7;82(3):603-17 - PubMed
  98. Neurochem Int. 2000 May;36(6):531-7 - PubMed
  99. Brain. 2001 Jan;124(Pt 1):2-4 - PubMed
  100. Vasc Cell. 2012 Dec 10;4(1):20 - PubMed
  101. NMR Biomed. 2008 Nov;21(10):1066-75 - PubMed
  102. J Biol Chem. 2013 Feb 15;288(7):4538-48 - PubMed
  103. Stroke. 1999 Jan;30(1):93-9 - PubMed
  104. Stroke. 2002 Feb;33(2):606-12 - PubMed
  105. PLoS One. 2012;7(12):e52121 - PubMed
  106. Stroke. 2013 Mar;44(3):870-947 - PubMed
  107. Stroke. 1999 Dec;30(12):2592-7 - PubMed
  108. Stroke. 2011 Jan;42(1 Suppl):S36-9 - PubMed
  109. J Cereb Blood Flow Metab. 2011 Sep;31(9):1836-51 - PubMed
  110. Prog Neurobiol. 2007 Feb;81(2):89-131 - PubMed
  111. Cerebrovasc Dis. 2013;35(2):146-54 - PubMed

Publication Types