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Dulger AC, Suvak B, Gonullu H, et al. High prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease. Arch Med Sci. 2016;12(2):415-20doi: 10.5114/aoms.2015.52030.
Dulger, A. C., Suvak, B., Gonullu, H., Gonullu, E., Gultepe, B., Aydın, �. �., Batur, A., Karadas, S., & Olmez, �. �. (2016). High prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease. Archives of medical science : AMS, 12(2), 415-20. https://doi.org/10.5114/aoms.2015.52030
Dulger, Ahmet Cumhur, et al. "High prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease." Archives of medical science : AMS vol. 12,2 (2016): 415-20. doi: https://doi.org/10.5114/aoms.2015.52030
Dulger AC, Suvak B, Gonullu H, Gonullu E, Gultepe B, Aydın İ, Batur A, Karadas S, Olmez Ş. High prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease. Arch Med Sci. 2016 Apr 01;12(2):415-20. doi: 10.5114/aoms.2015.52030. Epub 2016 Apr 12. PMID: 27186189; PMCID: PMC4848352.
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Arch Med Sci. 2016 Apr 01;12(2):415-20. doi: 10.5114/aoms.2015.52030. Epub 2016 Apr 12.

High prevalence of chronic hepatitis D virus infection in Eastern Turkey: urbanization of the disease.

Archives of medical science : AMS

Ahmet Cumhur Dulger, Burak Suvak, Hayriye Gonullu, Edip Gonullu, Bilge Gultepe, İbrahim Aydın, Abdüssamet Batur, Sevdegul Karadas, Şehmus Olmez

Affiliations

  1. Department of Gastroenterology, School of Medicine, Yuzuncu Yil University, Van, Turkey.
  2. Department of Emergency Medicine, School of Medicine, Yuzuncu Yil University, Van, Turkey.
  3. Department of Anesthesiology, Van Region Training and Research Hospital, Van, Turkey.
  4. Department of Microbiology, School of Medicine, Bezmialem Vak?f University, Istanbul, Turkey.
  5. Department of Radiology, School of Medicine, Yuzuncu Yil University, Van, Turkey.

PMID: 27186189 PMCID: PMC4848352 DOI: 10.5114/aoms.2015.52030

Abstract

INTRODUCTION: Both hepatitis B virus (HBV) and hepatitis D virus (HDV) infection play an increasingly important role in liver diseases. The main objective of this study was to investigate the socio-epidemiological, laboratory and radiological aspects of both HBV and HDV infection near the Iranian border of Turkey.

MATERIAL AND METHODS: The study included 3352 patients with HBV and HDV infection. Socioepidemiological, laboratory and radiological aspects of the study subjects were retrospectively examined. Comorbid metabolic diseases were not assessed due to the retrospective design of the study.

RESULTS: Most of the study subjects were HBe antigen negative. No significant difference in terms of HBV-DNA levels or HBe antigen seropositivity was detected between the city centre and rural areas (p > 0.005). The mean HBV-DNA level in the anti-HDV-positive group was significantly lower than in the anti-HDV-negative group (p < 0.001). The rate of HDV-RNA positivity in women was higher than in their male counterparts (p = 0.017). Anti-HDV-IgG was detected in 18.4% of tested subjects who came from an urban area. In contrast, 12.5% of subjects of the rural group had a positive result for anti-HDV-IgG. Among 134 ultrasonographically evaluated delta hepatitis patients, 37.3% had liver cirrhosis. On the other hand, in 1244 patients with hepatitis B monoinfection, there were 90 patients with liver cirrhosis. Radiologically, the rate of hepatic steatosis in delta hepatitis patients was lower than in those with HBV monoinfection.

CONCLUSIONS: Hepatitis D virus infection was particularly prevalent among the urban population as well as in female subjects. More broadly, the current observations are the first to suggest an inverse correlation between delta hepatitis and ultrasonography-proven hepatic steatosis.

Keywords: hepatitis B virus; hepatitis D virus; hepatosteatosis

References

  1. Clin Liver Dis. 2012 Aug;16(3):567-85 - PubMed
  2. J Hepatol. 2013 Nov;59(5):949-56 - PubMed
  3. PLoS One. 2014 Mar 21;9(3):e92062 - PubMed
  4. Turk J Gastroenterol. 2012;23 (5):560-8 - PubMed
  5. Lancet. 2011 Jul 2;378(9785):73-85 - PubMed
  6. Egypt J Immunol. 2013;20(1):23-8 - PubMed
  7. Addiction. 1998 Feb;93(2):243-51 - PubMed
  8. World J Gastroenterol. 2012 Aug 14;18(30):3945-54 - PubMed
  9. Med Glas (Zenica). 2014 Feb;11(1):94-8 - PubMed
  10. Dig Liver Dis. 2011 Jan;43 Suppl 1:S19-24 - PubMed
  11. Nat Rev Gastroenterol Hepatol. 2010 Jan;7(1):31-40 - PubMed
  12. N Engl J Med. 2005 Sep 22;353(12):1252-60 - PubMed
  13. Indian J Pathol Microbiol. 2011 Jul-Sep;54(3):454-9 - PubMed
  14. Transfus Apher Sci. 2014 Jun;50(3):388-91 - PubMed
  15. PLoS One. 2013 Oct 18;8(10):e78094 - PubMed
  16. J Emerg Manag. 2014 Jan-Feb;12(1):82-96 - PubMed
  17. J Hepatol. 2009 May;50(5):1043-50 - PubMed
  18. Infection. 1990 Jan-Feb;18(1):26-8 - PubMed
  19. BMC Infect Dis. 2014 Feb 21;14:94 - PubMed
  20. Turk J Gastroenterol. 2005 Mar;16(1):17-20 - PubMed

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