Display options
Cite
Shafaie S, Hutter V, Cook MT, et al. In Vitro Cell Models for Ophthalmic Drug Development Applications. Biores Open Access. 2016;5(1):94-108doi: 10.1089/biores.2016.0008.
Shafaie, S., Hutter, V., Cook, M. T., Brown, M. B., & Chau, D. Y. (2016). In Vitro Cell Models for Ophthalmic Drug Development Applications. BioResearch open access, 5(1), 94-108. https://doi.org/10.1089/biores.2016.0008
Shafaie, Sara, et al. "In Vitro Cell Models for Ophthalmic Drug Development Applications." BioResearch open access vol. 5,1 (2016): 94-108. doi: https://doi.org/10.1089/biores.2016.0008
Shafaie S, Hutter V, Cook MT, Brown MB, Chau DY. In Vitro Cell Models for Ophthalmic Drug Development Applications. Biores Open Access. 2016 Apr 01;5(1):94-108. doi: 10.1089/biores.2016.0008. eCollection 2016. PMID: 27158563; PMCID: PMC4845647.
Copy Download .nbib Format: NLM
Share it on

Biores Open Access. 2016 Apr 01;5(1):94-108. doi: 10.1089/biores.2016.0008. eCollection 2016.

In Vitro Cell Models for Ophthalmic Drug Development Applications.

BioResearch open access

Sara Shafaie, Victoria Hutter, Michael T Cook, Marc B Brown, David Y S Chau

Affiliations

  1. Department of Pharmacy, Pharmacology, and Postgraduate Medicine, The Research Center in Topical Drug Delivery and Toxicology, School of Life and Medical Sciences, University of Hertfordshire , Hertfordshire, United Kingdom .
  2. Department of Pharmacy, Pharmacology, and Postgraduate Medicine, The Research Center in Topical Drug Delivery and Toxicology, School of Life and Medical Sciences, University of Hertfordshire, Hertfordshire, United Kingdom.; MedPharm Ltd., Guildford, Surrey, United Kingdom.

PMID: 27158563 PMCID: PMC4845647 DOI: 10.1089/biores.2016.0008

Abstract

Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development of in vitro representations of organs for drug toxicity assessment. Due to the ever-increasing interest in ocular drug delivery as a route for administration as well as the rise of new ophthalmic therapeutics, there is a demand for physiologically accurate in vitro models of the eye to assess drug delivery and safety of new ocular medicines. This review summarizes current existing ocular models and highlights the important factors and limitations that need to be considered during their use.

Keywords: cell culture; drug delivery; ophthalmology; tissue engineering; toxicity testing

References

  1. Int J Ophthalmol. 2012;5(4):505-9 - PubMed
  2. Nature. 2003 Aug 21;424(6951):870-2 - PubMed
  3. Toxicol Appl Pharmacol. 1980 Sep 30;55(3):501-13 - PubMed
  4. Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2496-506 - PubMed
  5. Ophthalmic Res. 2003 May-Jun;35(3):126-36 - PubMed
  6. Curr Eye Res. 1995 Jun;14(6):435-42 - PubMed
  7. Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2942-8 - PubMed
  8. J Lipid Res. 2004 Feb;45(2):263-71 - PubMed
  9. Food Chem Toxicol. 1997 Jan;35(1):23-37 - PubMed
  10. Lab Invest. 2014 Feb;94(2):208-21 - PubMed
  11. Toxicol In Vitro. 2001 Apr;15(2):95-103 - PubMed
  12. Food Cosmet Toxicol. 1981 Aug;19(4):471-80 - PubMed
  13. Eye (Lond). 2008 Mar;22(3):461-8 - PubMed
  14. Int J Mol Sci. 2015 Mar 11;16(3):5517-27 - PubMed
  15. Toxicol In Vitro. 1997 Feb-Apr;11(1-2):121-39 - PubMed
  16. Trends Biotechnol. 2004 Feb;22(2):80-6 - PubMed
  17. Scand J Plast Reconstr Surg Hand Surg. 2002;36(6):340-8 - PubMed
  18. Eur J Pharm Biopharm. 2005 Jul;60(2):207-25 - PubMed
  19. Br J Ophthalmol. 1998 May;82(5):554-60 - PubMed
  20. Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3294-300 - PubMed
  21. Eur J Ophthalmol. 2001 Jul-Sep;11 Suppl 2:S23-9 - PubMed
  22. Surv Ophthalmol. 2001 May-Jun;45(6):493-515 - PubMed
  23. In Vitro Cell Dev Biol Anim. 1999 Oct;35(9):515-26 - PubMed
  24. Br J Ophthalmol. 2004 Apr;88(4):560-5 - PubMed
  25. J Cell Sci. 1993 Jan;104 ( Pt 1):37-49 - PubMed
  26. Am J Physiol Cell Physiol. 2003 Jun;284(6):C1497-507 - PubMed
  27. Toxicol In Vitro. 2001 Apr;15(2):115-30 - PubMed
  28. Toxicol Lett. 1984 Aug;22(2):199-203 - PubMed
  29. Clin Exp Ophthalmol. 2003 Aug;31(4):348-53 - PubMed
  30. Biomed Environ Sci. 2012 Jun;25(3):359-66 - PubMed
  31. Pharm Res. 2000 May;17(5):533-8 - PubMed
  32. Food Chem Toxicol. 1996 Jan;34(1):79-117 - PubMed
  33. Am J Ophthalmol. 1960 Jul;50:108-10 - PubMed
  34. Science. 1999 Dec 10;286(5447):2169-72 - PubMed
  35. Toxicol Sci. 2004 Dec;82(2):525-33 - PubMed
  36. Invest Ophthalmol Vis Sci. 2003 Feb;44(2):808-17 - PubMed
  37. Expert Rev Ophthalmol. 2008 Apr;3(2):211-218 - PubMed
  38. Vet Pathol. 2010 May;47(3):396-413 - PubMed
  39. Mol Vis. 2002 Nov 11;8:422-30 - PubMed
  40. Nippon Ganka Gakkai Zasshi. 1994 Apr;98(4):327-33 - PubMed
  41. J Pharmacol Toxicol Methods. 2015 Nov-Dec;76:65-71 - PubMed
  42. Invest Ophthalmol Vis Sci. 2011 Nov 04;52(12):8614-20 - PubMed
  43. Invest Ophthalmol Vis Sci. 1993 Jun;34(7):2316-24 - PubMed
  44. Invest Ophthalmol Vis Sci. 1997 May;38(6):1082-93 - PubMed
  45. Fundam Appl Toxicol. 1992 Apr;18(3):442-9 - PubMed
  46. Exp Eye Res. 2003 May;76(5):521-42 - PubMed
  47. Curr Eye Res. 1991 Jun;10(6):571-9 - PubMed
  48. Pharm Res. 1992 Jun;9(6):769-75 - PubMed
  49. Dis Model Mech. 2015 May;8(5):421-7 - PubMed
  50. Eur J Pharm Sci. 2010 Jul 11;40(4):289-96 - PubMed
  51. Jpn J Ophthalmol. 2004 May-Jun;48(3):236-42 - PubMed
  52. Exp Eye Res. 1994 Nov;59(5):587-96 - PubMed
  53. Curr Eye Res. 2006 Jul-Aug;31(7-8):599-606 - PubMed
  54. Acta Biomater. 2011 Mar;7(3):921-35 - PubMed
  55. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3215-24 - PubMed
  56. Curr Eye Res. 1996 Dec;15(12):1163-9 - PubMed
  57. World J Pharmacol. 2013;2(2):47-64 - PubMed
  58. Exp Cell Res. 1994 Oct;214(2):621-33 - PubMed
  59. Recent Pat Nanomed. 2012;2(2):82-95 - PubMed
  60. Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5293-300 - PubMed
  61. Graefes Arch Clin Exp Ophthalmol. 2004 Jan;242(1):65-7 - PubMed
  62. Eye (Lond). 2004 Nov;18(11):1066-74 - PubMed
  63. Toxicol In Vitro. 1998 Aug;12(4):455-61 - PubMed
  64. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):675-84 - PubMed
  65. Invest Ophthalmol Vis Sci. 1999 Jul;40(8):1738-44 - PubMed
  66. J Pharm Pharmacol. 1999 Jul;51(7):791-6 - PubMed
  67. PLoS One. 2014 May 16;9(5):e96448 - PubMed
  68. Invest Ophthalmol Vis Sci. 1998 Jun;39(7):1221-6 - PubMed
  69. Invest Ophthalmol Vis Sci. 1999 May;40(6):1091-101 - PubMed
  70. Clin Exp Immunol. 1998 Apr;112(1):34-43 - PubMed
  71. J Biomater Appl. 1994 Oct;9(2):121-37 - PubMed
  72. Toxicol In Vitro. 2013 Mar;27(2):619-26 - PubMed
  73. Invest Ophthalmol Vis Sci. 1985 Apr;26(4):584-7 - PubMed
  74. Exp Eye Res. 1996 Feb;62(2):155-69 - PubMed
  75. Arch Toxicol. 2011 Aug;85(8):841-58 - PubMed
  76. J Ocul Pharmacol Ther. 2002 Oct;18(5):455-68 - PubMed
  77. Artif Organs. 2010 Oct;34(10):836-45 - PubMed
  78. Exp Eye Res. 2003 Oct;77(4):395-407 - PubMed
  79. In Vitro Cell Dev Biol. 1990 Sep;26(9):923-30 - PubMed
  80. J Pharm Pharmacol. 2003 Sep;55(9):1199-206 - PubMed
  81. Altern Lab Anim. 2011 Mar;39(1):15-22 - PubMed
  82. Toxicol In Vitro. 2006 Feb;20(1):1-17 - PubMed
  83. Fundam Appl Toxicol. 1986 Nov;7(4):626-34 - PubMed
  84. Toxicology. 2015 Jan 2;327:32-46 - PubMed
  85. Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4263-74 - PubMed
  86. Invest Ophthalmol Vis Sci. 1995 Mar;36(3):614-21 - PubMed
  87. Toxicol In Vitro. 2010 Feb;24(1):1-9 - PubMed
  88. Curr Eye Res. 1998 Feb;17(2):125-31 - PubMed
  89. Pflugers Arch. 2000 May;440(1):84-92 - PubMed
  90. Invest Ophthalmol Vis Sci. 1995 Apr;36(5):955-64 - PubMed
  91. Biomaterials. 2008 Jun;29(18):2802-12 - PubMed
  92. Jpn J Ophthalmol. 1995;39(4):323-33 - PubMed
  93. Curr Eye Res. 1997 Jun;16(6):572-6 - PubMed
  94. Toxicol In Vitro. 2005 Sep;19(6):823-30 - PubMed
  95. Biosci Rep. 2003 Aug;23(4):169-74 - PubMed
  96. Invest Ophthalmol Vis Sci. 1998 Aug;39(9):1600-8 - PubMed
  97. Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1154-61 - PubMed
  98. Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1202-10 - PubMed
  99. Int J Artif Organs. 2003 Aug;26(8):764-73 - PubMed
  100. Curr Eye Res. 1998 Mar;17(3):225-30 - PubMed
  101. Adv Exp Med Biol. 2012;763:70-84 - PubMed
  102. J Pharm Sci. 2011 Jan;100(1):59-74 - PubMed
  103. Prog Retin Eye Res. 2000 Sep;19(5):497-527 - PubMed
  104. Exp Eye Res. 2001 Feb;72(2):163-72 - PubMed
  105. Toxicol In Vitro. 2011 Feb;25(1):403-10 - PubMed
  106. Toxicol In Vitro. 2002 Apr;16(2):193-200 - PubMed
  107. Int J Pharm. 2003 Jan 2;250(1):191-201 - PubMed
  108. Cornea. 2002 Jul;21(5):505-10 - PubMed
  109. J Physiol. 1972 Oct;226(2):407-29 - PubMed
  110. Pharm Res. 2000 Jun;17(6):670-6 - PubMed
  111. Environ Health Perspect. 2008 Sep;116(9):A381 - PubMed
  112. Invest Ophthalmol Vis Sci. 1995 Nov;36(12):2523-30 - PubMed
  113. Nat Genet. 1999 Jan;21(1):111-4 - PubMed
  114. Ocul Surf. 2005 Jul;3(3):126-42 - PubMed
  115. Curr Eye Res. 1996 Dec;15(12):1170-4 - PubMed
  116. Science. 1998 Jan 16;279(5349):349-52 - PubMed
  117. Food Chem Toxicol. 1996 Aug;34(8):737-49 - PubMed
  118. Exp Eye Res. 2003 Jun;76(6):735-43 - PubMed
  119. Indian J Pharmacol. 2014 May-Jun;46(3):257-65 - PubMed
  120. J Ophthalmic Vis Res. 2009 Oct;4(4):238-52 - PubMed
  121. J Membr Biol. 1983;73(3):275-82 - PubMed
  122. Exp Eye Res. 2003 Nov;77(5):593-9 - PubMed
  123. Eur J Pharm Biopharm. 2001 Mar;51(2):119-25 - PubMed
  124. Altern Lab Anim. 2005 Jul;33 Suppl 1:47-81 - PubMed
  125. Invest Ophthalmol Vis Sci. 1994 Apr;35(5):2466-76 - PubMed
  126. Prog Retin Eye Res. 2013 May;34:19-48 - PubMed
  127. Invest Ophthalmol Vis Sci. 1993 Nov;34(12):3429-41 - PubMed
  128. Food Chem Toxicol. 1993 Jan;31(1):69-76 - PubMed
  129. Invest Ophthalmol Vis Sci. 1997 Mar;38(3):635-42 - PubMed
  130. Lens Eye Toxic Res. 1989;6(3):395-403 - PubMed
  131. Ophthalmic Physiol Opt. 2009 Sep;29(5):557-64 - PubMed
  132. Mol Vis. 2001 Feb 07;7:14-9 - PubMed
  133. Invest Ophthalmol Vis Sci. 1997 Jul;38(8):1578-87 - PubMed
  134. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1716-21 - PubMed
  135. Ophthalmology. 2013 Sep;120(9):1778-85 - PubMed
  136. Invest Ophthalmol Vis Sci. 1993 Aug;34(9):2665-71 - PubMed
  137. J Pharmacol Toxicol Methods. 2010 Mar-Apr;61(2):136-45 - PubMed
  138. Invest Ophthalmol Vis Sci. 2000 Jul;41(8):2389-93 - PubMed
  139. Eur J Ophthalmol. 2003 Jul;13(6):515-24 - PubMed
  140. Food Chem Toxicol. 2000 Aug;38(8):727-34 - PubMed
  141. J Control Release. 2000 Mar 1;65(1-2):1-11 - PubMed
  142. Surv Ophthalmol. 2011 Jul-Aug;56(4):300-23 - PubMed
  143. Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2365-73 - PubMed
  144. Annu Rev Pharmacol Toxicol. 1998;38:63-96 - PubMed
  145. Pharm Res. 2003 Sep;20(9):1357-63 - PubMed
  146. Regul Toxicol Pharmacol. 2006 Oct;46(1):18-22 - PubMed
  147. Fundam Appl Toxicol. 1997 Apr;36(2):130-40 - PubMed
  148. Altern Lab Anim. 2002 Dec;30 Suppl 2:69-74 - PubMed

Publication Types