Display options
Cite
Verma A, Kumar I, Verma N, et al. Magnetic resonance spectroscopy - Revisiting the biochemical and molecular milieu of brain tumors. BBA Clin. 2016;5:170-8doi: 10.1016/j.bbacli.2016.04.002.
Verma, A., Kumar, I., Verma, N., Aggarwal, P., & Ojha, R. (2016). Magnetic resonance spectroscopy - Revisiting the biochemical and molecular milieu of brain tumors. BBA clinical, 5170-8. https://doi.org/10.1016/j.bbacli.2016.04.002
Verma, Ashish, et al. "Magnetic resonance spectroscopy - Revisiting the biochemical and molecular milieu of brain tumors." BBA clinical vol. 5 (2016): 170-8. doi: https://doi.org/10.1016/j.bbacli.2016.04.002
Verma A, Kumar I, Verma N, Aggarwal P, Ojha R. Magnetic resonance spectroscopy - Revisiting the biochemical and molecular milieu of brain tumors. BBA Clin. 2016 Apr 12;5:170-8. doi: 10.1016/j.bbacli.2016.04.002. eCollection 2016 Jun. PMID: 27158592; PMCID: PMC4845155.
Copy Download .nbib Format: NLM
Share it on

BBA Clin. 2016 Apr 12;5:170-8. doi: 10.1016/j.bbacli.2016.04.002. eCollection 2016 Jun.

Magnetic resonance spectroscopy - Revisiting the biochemical and molecular milieu of brain tumors.

BBA clinical

Ashish Verma, Ishan Kumar, Nimisha Verma, Priyanka Aggarwal, Ritu Ojha

Affiliations

  1. Department of Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
  2. Department of Anesthesiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
  3. Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
  4. Consultant Radiologist.

PMID: 27158592 PMCID: PMC4845155 DOI: 10.1016/j.bbacli.2016.04.002

Abstract

BACKGROUND: Magnetic resonance spectroscopy (MRS) is an established tool for in-vivo evaluation of the biochemical basis of human diseases. On one hand, such lucid depiction of 'live biochemistry' helps one to decipher the true nature of the pathology while on the other hand one can track the response to therapy at sub-cellular level. Brain tumors have been an area of continuous interrogation and instigation for mankind. Evaluation of these lesions by MRS plays a crucial role in the two aspects of disease management described above.

SCOPE OF REVIEW: Presented is an overview of the window provided by MRS into the biochemical aspects of brain tumors. We systematically visit each metabolite deciphered by MRS and discuss the role of deconvoluting the biochemical aspects of pathologies (here in context of brain tumors) in the disease management cycle. We further try to unify a radiologist's perspective of disease with that of a biochemist to prove the point that preclinical work is the mother of the treatment we provide at bedside as clinicians. Furthermore, an integrated approach by various scientific experts help resolve a query encountered in everyday practice.

MAJOR CONCLUSIONS: MR spectroscopy is an integral tool for evaluation and systematic follow-up of brain tumors. A deeper understanding of this technology by a biochemist would help in a swift and more logical development of the technique while a close collaboration with radiologist would enable definitive application of the same.

GENERAL SIGNIFICANCE: The review aims at inciting closer ties between the two specialists enabling a deeper understanding of this valuable technology.

Keywords: Choline; Creatine; MR spectroscopy; NAA; Spectroscopic peaks

References

  1. AJNR Am J Neuroradiol. 2007 Aug;28(7):1287-91 - PubMed
  2. NMR Biomed. 2001 Aug;14(5):307-17 - PubMed
  3. J Comput Assist Tomogr. 2010 Nov-Dec;34(6):836-41 - PubMed
  4. Brain Tumor Pathol. 2006 Apr;23(1):35-40 - PubMed
  5. JBR-BTR. 2011 Nov-Dec;94(6):319-29 - PubMed
  6. Neuroimaging Clin N Am. 2010 Aug;20(3):293-310 - PubMed
  7. Lancet. 1986 Jul 5;2(8497):8-11 - PubMed
  8. Brain Res. 1978 Aug 11;151(3):604-8 - PubMed
  9. J Comput Assist Tomogr. 2005 Sep-Oct;29(5):683-8 - PubMed
  10. NMR Biomed. 1997 Jan;10(1):2-12 - PubMed
  11. Magn Reson Imaging. 2008 Jan;26(1):59-64 - PubMed
  12. MAGMA. 2009 Feb;22(1):5-18 - PubMed
  13. Eur J Radiol. 2006 Oct;60(1):48-55 - PubMed
  14. Radiology. 1996 May;199(2):423-8 - PubMed
  15. Int J Mol Med. 2006 Nov;18(5):859-69 - PubMed
  16. Cancer Res. 1995 Aug 1;55(15):3286-94 - PubMed
  17. Biochem Biophys Res Commun. 1997 Oct 29;239(3):868-74 - PubMed
  18. Brain Res. 1991 Dec 13;567(1):64-70 - PubMed
  19. Clin Cancer Res. 2000 Oct;6(10 ):3983-93 - PubMed
  20. J Magn Reson Imaging. 2003 Feb;17(2):256-60 - PubMed
  21. Biochem Soc Trans. 1991 Nov;19(4):995-6 - PubMed
  22. J Neurochem. 1977 Jul;29(1):83-6 - PubMed
  23. J Chromatogr. 1981 Nov 6;217:231-7 - PubMed
  24. Magn Reson Med. 2003 Feb;49(2):223-32 - PubMed
  25. Cancer Res. 2002 Feb 1;62(3):688-95 - PubMed
  26. Nat Rev Cancer. 2004 Jul;4(7):551-61 - PubMed
  27. NMR Biomed. 2003 Feb;16(1):12-8 - PubMed
  28. J Neuroimaging. 2012 Apr;22(2):184-90 - PubMed
  29. Radiology. 1990 Feb;174(2):401-9 - PubMed
  30. Radiology. 1992 Jan;182(1):19-27 - PubMed
  31. Eur J Paediatr Neurol. 2011 May;15(3):214-21 - PubMed
  32. J Neurooncol. 2009 Jan;91(1):69-81 - PubMed
  33. Cancer Res. 2003 Jun 15;63(12):3195-201 - PubMed
  34. J Magn Reson Imaging. 2016 Oct;44(4):823-33 - PubMed
  35. Life Sci. 1996;58(22):1929-35 - PubMed
  36. Neuroimaging Clin N Am. 2006 Nov;16(4):605-18, viii - PubMed
  37. Comput Med Imaging Graph. 2001 Sep-Oct;25(5):417-22 - PubMed
  38. AJNR Am J Neuroradiol. 2006 Apr;27(4):895-901 - PubMed
  39. Magn Reson Med. 2009 Oct;62(4):868-79 - PubMed
  40. AJNR Am J Neuroradiol. 2000 Oct;21(9):1645-9 - PubMed
  41. NMR Biomed. 1989 Dec;2(5-6):201-8 - PubMed
  42. Biochem Cell Biol. 1998;76(2-3):477-86 - PubMed
  43. Magn Reson Imaging. 1992;10(2):227-43 - PubMed
  44. NMR Biomed. 2012 Apr;25(4):685-94 - PubMed
  45. Biochim Biophys Acta. 1968 May 1;152(3):611-8 - PubMed
  46. AJNR Am J Neuroradiol. 2006 Apr;27(4):794-8 - PubMed
  47. Stereotact Funct Neurosurg. 2011;89(4):234-45 - PubMed
  48. Lancet. 1991 Mar 23;337(8743):745-6 - PubMed
  49. Biochem J. 1993 May 1;291 ( Pt 3):915-9 - PubMed
  50. J Neurosci Res. 1980;5(4):271-80 - PubMed
  51. Brain. 1994 Feb;117 ( Pt 1):49-58 - PubMed
  52. Cancer Res. 2013 Mar 1;73(5):1470-80 - PubMed
  53. Magn Reson Med. 1991 Jun;19(2):439-45 - PubMed
  54. J Neurosci. 1993 Mar;13(3):981-9 - PubMed
  55. Magn Reson Med. 2012 Sep;68(3):662-70 - PubMed
  56. AJNR Am J Neuroradiol. 2003 Nov-Dec;24(10):1989-98 - PubMed
  57. AJNR Am J Neuroradiol. 2005 Feb;26(2):279-88 - PubMed
  58. Eur Radiol. 2003 Mar;13(3):582-91 - PubMed
  59. J Neurooncol. 2007 Aug;84(1):63-9 - PubMed
  60. Prog Clin Biol Res. 1985;179:361-70 - PubMed
  61. Magn Reson Imaging Clin N Am. 1998 Feb;6(1):1-20 - PubMed
  62. Dev Neurosci. 1991;13(6):403-11 - PubMed
  63. Neuroradiology. 2002 May;44(5):371-81 - PubMed
  64. Radiology. 1992 Jul;184(1):123-30 - PubMed
  65. Magn Reson Med. 1989 Sep;11(3):349-66 - PubMed
  66. Neurosurg Focus. 2005 Jun 15;18(6A):E4 - PubMed
  67. Clin Cancer Res. 2004 Dec 15;10(24):8220-8 - PubMed
  68. J Neurosurg. 1991 Mar;74(3):447-53 - PubMed
  69. Radiology. 2004 Feb;230(2):519-27 - PubMed
  70. J Neuroimaging. 1995 Jul;5(3):157-63 - PubMed
  71. Acta Radiol. 2010 Apr;51(3):316-25 - PubMed
  72. Neuroradiology. 2007 Jul;49(7):551-4 - PubMed
  73. Clin Radiol. 2011 Aug;66(8):768-77 - PubMed
  74. NMR Biomed. 2006 Jun;19(4):411-34 - PubMed
  75. J Neurochem. 1977 Dec;29(6):959-77 - PubMed
  76. Prog Neurobiol. 2007 Feb;81(2):89-131 - PubMed
  77. Neuroradiology. 2004 Jul;46(7):541-9 - PubMed

Publication Types