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Anderson JC, Taylor RB, Fiveash JB, et al. KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA. Med Res Arch. 2015;2015(3)doi: 10.18103/mra.v0i3.104.
Anderson, J. C., Taylor, R. B., Fiveash, J. B., de Wijn, R., Gillespie, G. Y., & Willey, C. D. (2015). KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA. Medical research archives, 2015(3), . https://doi.org/10.18103/mra.v0i3.104
Anderson, Joshua C, et al. "KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA." Medical research archives vol. 2015,3 (2015). doi: https://doi.org/10.18103/mra.v0i3.104
Anderson JC, Taylor RB, Fiveash JB, de Wijn R, Gillespie GY, Willey CD. KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA. Med Res Arch. 2015 Jul;2015(3). doi: 10.18103/mra.v0i3.104. PMID: 27158663; PMCID: PMC4856299.
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Med Res Arch. 2015 Jul;2015(3). doi: 10.18103/mra.v0i3.104.

KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA.

Medical research archives

Joshua C Anderson, Robert B Taylor, John B Fiveash, Rik de Wijn, G Yancey Gillespie, Christopher D Willey

Affiliations

  1. University of Alabama at Birmingham, Department of Radiation Oncology.
  2. PamGene International B.V., 's-Hertogenbosch, The Netherlands.

PMID: 27158663 PMCID: PMC4856299 DOI: 10.18103/mra.v0i3.104

Abstract

BACKGROUND: We sought to profile Atypical Meningioma in a high-throughput manner to better understand the altered signaling within these tumors and specifically the kinases altered in recurrent atypical meningioma. Kinomic Profiles could be used to identify prognostic biomarkers for responders/non-responders to classify future patients that are unlikely to benefit from current therapies. Directly these results could be used to identify drug-actionable kinase targets as well.

METHODS: Peptide-substrate microarray kinase activity analysis was conducted with a PamStation

RESULTS: 3 major clusters of atypical meningiomas were identified with highly variant peptides primarily being targets of EGFR family, ABL, BRK and BMX kinases. Kinomic analysis of recurrent atypical meningiomas indicated patterns of increased phosphorylation of BMX, TYRO3 and FAK substrates as compared to non-recurrent tumors.

CONCLUSION: The atypical meningiomas profiled here exhibited molecular sub-clustering that may have phenotypic corollaries predictive of outcome. Recurrent tumors had increases in kinase activity that may predict resistance to current therapies, and may guide selection of directed therapies. Taken together these data further the understanding of kinomic alteration in atypical meningioma, and the processes that may not only mediate recurrence, but additionally may identify kinase targets for intervention.

Keywords: kinase activity; kinomics; meningioma; personalized medicine; radiation

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